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公开(公告)号：US20150148550A1
公开(公告)日：2015-05-28
申请号：US14092151
申请日：2013-11-27
发明人： Eun Joo ROH , Changjoon Justin LEE , Soo Jin OH , Jong Hoon JUNG
IPC分类号： C07D333/40 , C07C205/57 , C07C63/70 , C07C65/03 , C07C65/21 , C07C205/58 , C07C205/59
CPC分类号： C07D333/40 , C07C229/56 , C07C229/58
摘要： Disclosed is a novel compound to function as a calcium-dependent chloride channel blocking agent.
摘要翻译： 公开了一种用作钙依赖性氯离子通道阻断剂的新型化合物。
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公开(公告)号：US20140093490A1
公开(公告)日：2014-04-03
申请号：US13948476
申请日：2013-07-23
发明人： Changjoon Justin LEE , Soo Jin OH , Eun Mi HWANG , Dong Ho WOO
IPC分类号： A61K38/45 , C12N15/113 , A61K38/08 , A61K38/10 , A61K38/17 , G01N33/50 , A61K31/4168 , A61K31/519 , A61K31/4045 , A61K31/5375 , A61K31/135 , A61K31/522 , A61K31/49 , A61K35/74
CPC分类号： A61K38/45 , A61K31/135 , A61K31/137 , A61K31/185 , A61K31/225 , A61K31/4045 , A61K31/4168 , A61K31/426 , A61K31/44 , A61K31/4439 , A61K31/4545 , A61K31/49 , A61K31/519 , A61K31/522 , A61K31/5375 , A61K31/662 , A61K35/74 , A61K38/00 , A61K38/08 , A61K38/10 , A61K38/1709 , C07K7/06 , C07K7/08 , C12N15/1138 , C12N2310/14 , C12N2310/531 , G01N33/5008 , G01N33/5058 , G01N33/6872
摘要： The present invention investigate the two modes of glutamate release and the releasing rate of glutamate, and thus can provide a useful technique for neuron protection and acceleration of neurotransmission by controlling the glutamate release in astroctye. Thus, the present invention provides an inhibitor of the fast-mode release and/or the slow-mode release of astrocytic glutamate, a screening method of the inhibitor and a pharmaceutical composition or method of ameliorating, preventing and/or treating the disease associated with the over-release of glutamate via the Ca2+-activated anion channel, with the inhibition of fast-mode glutamate release.
摘要翻译： 本发明研究谷氨酸释放和谷氨酸释放的两种模式，从而通过控制天冬氨酸的谷氨酸释放，为神经元保护和神经传递加速提供了有用的技术。 因此，本发明提供了星形细胞性谷氨酸的快速释放和/或慢速释放抑制剂，抑制剂的筛选方法以及改善，预防和/或治疗与 通过Ca2 +活化的阴离子通道过度释放谷氨酸，抑制快速谷氨酸释放。
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