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公开(公告)号：US10683483B2
公开(公告)日：2020-06-16
申请号：US16293618
申请日：2019-03-05
发明人： Jung-Hwa Oh , Jaehwan Ahn , Seokjoo Yoon , Heeyoung Yang , Jun-Ho Ahn , Mi-Sun Choi , Soojin Kim , Se-Myo Park , Hyoung-Yun Han
摘要： A microfabricated platform for mimicking the liver zonation and an evaluating method of zone-specific hepatotoxicity using the same is provided. The microfabricated platform for mimicking the liver zonation prepared according to the method of the present invention is divided into three zones of zone 1, zone 2 and zone 3 similarly to in vivo liver tissue and thus the zone-specific hepatotoxicity of a drug in the liver can be evaluated using the same. According to the present invention, the zone-specific hepatotoxicity results can be analyzed quantitatively by using image analysis, so that the platform of the present invention can be effectively used for in vitro screening of zone-specific hepatotoxicity.
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公开(公告)号：US20240219333A1
公开(公告)日：2024-07-04
申请号：US18003757
申请日：2021-06-15
申请人： KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY , KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
发明人： Jung-Hwa Oh , Jaehwan Ahn , Seokjoo Yoon , Hyoung-Yun Han , Mi Young Son , Kwang Bo Jung , Cho Rok Jung , Janghwan Kim
IPC分类号： G01N27/04 , C12M1/26 , C12M1/34 , G01N33/483
CPC分类号： G01N27/041 , C12M33/04 , C12M33/12 , C12M41/40 , G01N33/4833
摘要： The present invention provides an impedance-based organoid evaluation system comprising an organoid deformation generating unit including a first tube and a plurality of second tubes having a diameter smaller than that of the first tube, connected to one end of the first tube or inserted therein; and an impedance measuring unit connected to the organoid deformation generating unit and including an impedance analyzer for measuring the impedance of the organoid, and evaluating the organoid from the impedance measured by the impedance measuring unit.
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公开(公告)号：US20230093162A1
公开(公告)日：2023-03-23
申请号：US18070401
申请日：2022-11-28
发明人： Jung-Hwa Oh , Jaehwan Ahn , Seokjoo Yoon , Jun-Ho Ahn , Heeyoung Yang , Hyoung-Yun Han
摘要： The present invention relates to a fatty liver and liver fibrosis evaluation system based on impedance. The fatty liver and liver fibrosis evaluation system based on impedance provided in one aspect of the present invention uses 3-dimensional liver microtissues so that the fatty liver formation and the stiffness changes resulted from liver fibrosis induced by a test drug can be analyzed with non-invasive and highly reproducible manner.
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公开(公告)号：US20240148810A1
公开(公告)日：2024-05-09
申请号：US18279975
申请日：2021-03-19
发明人： Hyoung-Yun Han , Jung-Hwa Oh , Seokjoo Yoon , Se-Myo Park , Mi-Sun Choi , Soojin Kim
IPC分类号： A61K36/296 , A61K36/07 , A61K36/69 , A61P29/00 , A61P39/06
CPC分类号： A61K36/296 , A61K36/07 , A61K36/69 , A61P29/00 , A61P39/06 , A61K2236/331
摘要： The present invention relates to an anti-inflammatory composition comprising Epimedium koreanum Nakai, Polygala tenuifolia Willd, and Polyporus umbellatus Fries extracts or a mixture thereof as an active ingredient. The extracts and mixture prepared according to the present invention exhibit a high inhibitory effect against nitric oxide and a suppressive effect against the expression of iNOS and COX2 and thus can be advantageously used as an anti-inflammatory composition.
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