Abstract:
The present disclosure provides systems and methods for sample preparation, processing and analysis. Also provided in the present disclosure is a fully-integrated electrophoresis cartridge which has a small footprint and configured to removably engage with the system.
Abstract:
An electrophoresis cartridge can include an integrated electrophoresis assembly including an anode sub-assembly comprising an anode, a cathode sub-assembly comprising a cathode; and at least one electrophoresis capillary having a first end in fluid communication with the cathode sub-assembly and a second end in fluid communication with the anode sub-assembly. The cartridge can further include a reagent container comprising electrophoresis buffer; a fluid conduit in fluidic communication with the reagent container; a pump in fluidic communication with the fluid conduit, the pump configured to transfer the electrophoresis buffer through the fluid conduit from the reagent container to the passage of the cathode sub-assembly; and a sample inlet port and at least one sample line, wherein the sample line places the sample inlet port in fluidic communication with the first end of the electrophoresis capillary through a passage in the cathode sub-assembly.
Abstract:
A method includes providing a system comprising an electrophoresis cartridge interface that releasably engages with an electrophoresis cartridge that includes an anode, a cathode, and at least one electrophoresis capillary that is in fluid communication with the anode and the cathode. The method further includes receiving the electrophoresis cartridge at said electrophoresis cartridge interface and automatically establishing at least one of (i) optical communication between an optical detection assembly of the system and a portion of the at least one electrophoresis capillary, (ii) electrical communication between the system and the anode and cathode, (iii) fluidic communication between the system and the at least one electrophoresis capillary, (iv) thermal communication between the system and the electrophoresis cartridge or the at least one electrophoresis capillary; (v) electromagnetic communication between the system and the electrophoresis cartridge and (vi) magnetic communication between the system and the electrophoresis cartridge.
Abstract:
The present disclosure provides systems and methods for sample preparation, processing and analysis. Also provided in the present disclosure is a fully-integrated electrophoresis cartridge which has a small footprint and configured to removably engage with the system.
Abstract:
The present disclosure provides systems and methods for sample preparation, processing and analysis. Also provided in the present disclosure is a fully-integrated electrophoresis cartridge which has a small footprint and configured to removably engage with the system.