公开(公告)号：US12092607B2

公开(公告)日：2024-09-17

申请号：US18341078

申请日：2023-06-26

Applicant: Hitachi High-Tech Corporation

Inventor： Satoshi Takahashi ,  Ryoji Inaba ,  Takashi Anazawa ,  Tomoyuki Sakai ,  Yusuke Goto

IPC: G01N27/447 ,  G01N21/64 ,  G01N30/74

CPC classification number: G01N27/44756 ,  G01N27/44721 ,  G01N2021/6463 ,  G01N27/44791 ,  G01N30/74

Abstract: The present invention aims to provide an electrophoresis apparatus which makes it possible to execute protein analysis with a high throughput. The electrophoresis apparatus according to the present invention is equipped with a capillary array which is configured by arraying a plurality of capillaries, a measurement light irradiation unit which irradiates with measurement light, a first lens array which includes a plurality of first lenses which are arrayed in correspondence with the plurality of capillaries, a second lens array which includes a plurality of second lenses which are arrayed in correspondence with the plurality of capillaries, and a light receiving unit which receives light which is incident upon the capillaries via the first lens array from the measurement light irradiation unit via the second lens array.

公开(公告)号：US20210316310A1

公开(公告)日：2021-10-14

申请号：US17220166

申请日：2021-04-01

Applicant: Hitachi High-Tech Corporation

Inventor： Naoshi Itabashi ,  Michiru Fujioka ,  Shuhei Yamamoto ,  Yoshimitsu Yanagawa ,  Yusuke Goto

IPC: B01L3/00

Abstract: Provided is a technique for moving all of a droplet from a microchannel in which the droplet have been introduced to another layer.
The droplet transport device of the present disclosure includes a substrate having a through-hole or a recess, a first electrode provided on the substrate along the surface of the substrate and arranged at a position adjacent to the through-hole or the recess, a plurality of second electrodes provided on the substrate along a surface of the substrate and to which a voltage for moving the droplet introduced on the substrate is applied, and a dielectric layer covering the surface of the substrate, the first electrode, and the second electrodes, and a water-repellent film provided on the inner wall surface of the through-hole or the recess, and on the dielectric layer.

公开(公告)号：US11733205B2

公开(公告)日：2023-08-22

申请号：US17253805

申请日：2018-06-22

Applicant: HITACHI HIGH-TECH CORPORATION

Inventor： Satoshi Takahashi ,  Ryoji Inaba ,  Takashi Anazawa ,  Tomoyuki Sakai ,  Yusuke Goto

IPC: G01N27/453 ,  G01N27/447 ,  G01N30/74 ,  G01N21/64

CPC classification number: G01N27/44756 ,  G01N27/44721 ,  G01N30/74 ,  G01N2021/6463

Abstract: The present invention aims to provide an electrophoresis apparatus which makes it possible to execute protein analysis with a high throughput. The electrophoresis apparatus according to the present invention is equipped with a capillary array which is configured by arraying a plurality of capillaries, a measurement light irradiation unit which irradiates with measurement light, a first lens array which includes a plurality of first lenses which are arrayed in correspondence with the plurality of capillaries, a second lens array which includes a plurality of second lenses which are arrayed in correspondence with the plurality of capillaries, and a light receiving unit which receives light which is incident upon the capillaries via the first lens array from the measurement light irradiation unit via the second lens array.

公开(公告)号：US11371980B2

公开(公告)日：2022-06-28

申请号：US16340995

申请日：2016-10-20

Applicant: HITACHI HIGH-TECH CORPORATION

Inventor： Michiru Fujioka ,  Yusuke Goto

IPC: C12Q1/6806 ,  G01N33/487 ,  C12Q1/6869 ,  G01N27/447 ,  C12Q1/6839 ,  C12Q1/6832

Abstract: The purpose of the present invention is to provide a method for treating biomolecules and a method for analyzing biomolecules with which it is possible to effectively suppress the clog of nanopores. The present invention is a method for treating biomolecules for analysis in which nanopores are used, wherein the method includes a step for preparing a sample solution that includes ammonium cations represented by a prescribed formula and biomolecules in which at least a portion of the higher-order structure has been fused.

公开(公告)号：US11275074B2

公开(公告)日：2022-03-15

申请号：US15506090

申请日：2015-07-06

Applicant: HITACHI HIGH-TECH CORPORATION

Inventor： Yusuke Goto ,  Takanobu Haga

IPC: G01N33/487 ,  C12Q1/6869 ,  G01N27/416

Abstract: To slow down the speed of a biopolymer passing through a nanopore during electrophoresis to such a speed that enables a monomer sequence analysis to be performed. A biopolymer analysis device includes two tanks 101a and 101b each capable of storing a solution containing a biopolymer and an electrolyte, a pair of electrodes 105a and 105b, a thin film 104 with a nanopore, and a three-dimensional structure 103 disposed on the thin film. The three-dimensional structure has a void that can store a solution, and the void forms a flow channel, the flow channel being adapted to allow the solution to pass therethrough from the nanopore to a portion above the three-dimensional structure, and having on its surface a functional group capable of adsorbing the biopolymer. Thus, when a voltage is applied, the three-dimensional structure is not re-dispersed in the solution at least in the range of a hemisphere having the nanopore as the center and having a biopolymer trapping length r as the radius.