公开(公告)号：US09138579B2

公开(公告)日：2015-09-22

申请号：US14502295

申请日：2014-09-30

Applicant: HEALTH RESEARCH, INC.

Inventor： Jonathan R. Wolpaw ,  Gerwin Schalk ,  Aiko K. Thompson ,  Peter Brunner ,  Xiang Yang Chen ,  Dennis J. McFarland

IPC: A61N1/00 ,  A61N1/36 ,  A61B5/0488 ,  A61N1/04 ,  A61B5/0492 ,  A61B5/00

CPC classification number: A61N1/36014 ,  A61B5/0488 ,  A61B5/0492 ,  A61B5/4848 ,  A61B5/6828 ,  A61B5/742 ,  A61B2562/046 ,  A61N1/0456 ,  A61N1/0476 ,  A61N1/36003 ,  A61N1/36025 ,  A61N1/36082 ,  A61N1/36103

Abstract: The present invention provides methods, devices, and systems for restoring or improving nervous system function of a subject. Provided is a method involving: (i) providing an operant conditioning protocol effective to produce targeted neural plasticity (TNP) in a primary targeted central nervous system (CNS) pathway of a subject; and (ii) administering the operant conditioning protocol to the subject to elicit TNP in the primary targeted CNS pathway and to elicit generalized neural plasticity (GNP) in one or more other CNS pathway. The elicitation of the GNP in the one or more other CNS pathway serves to restore or improve a nervous system function of the subject. Provided is a device comprising a nerve stimulation-electromyographic recording component and a controller for operating the nerve stimulation-electromyographic recording component in accordance with an operant conditioning protocol.

Abstract translation: 本发明提供了用于恢复或改善受试者的神经系统功能的方法，装置和系统。 提供了一种方法，其包括：（i）提供有效地在受试者的主要靶向中枢神经系统（CNS）途径中产生靶向神经可塑性（TNP）的操作调节方案; 和（ii）向受试者施用操作调节方案以在主要靶向CNS途径中引发TNP，并在一个或多个其它CNS途径中引发广义神经可塑性（GNP）。 在一种或多种其他CNS途径中引发GNP用于恢复或改善受试者的神经系统功能。 提供了包括神经刺激 - 肌电记录部件和根据操作调节方案来操作神经刺激 - 肌电图记录部件的控制器的装置。

公开(公告)号：US09545515B2

公开(公告)日：2017-01-17

申请号：US14855879

申请日：2015-09-16

Applicant: Health Research, Inc.

Inventor： Jonathan R. Wolpaw ,  Gerwin Schalk ,  Aiko K. Thompson ,  Peter Brunner ,  Xiang Yang Chen ,  Dennis J. McFarland

IPC: A61N1/00 ,  A61N1/36 ,  A61B5/0488 ,  A61N1/04 ,  A61B5/0492 ,  A61B5/00

CPC classification number: A61N1/36014 ,  A61B5/0488 ,  A61B5/0492 ,  A61B5/4848 ,  A61B5/6828 ,  A61B5/742 ,  A61B2562/046 ,  A61N1/0456 ,  A61N1/0476 ,  A61N1/36003 ,  A61N1/36025 ,  A61N1/36082 ,  A61N1/36103

Abstract: The present invention provides methods, devices, and systems for restoring or improving nervous system function of a subject. Provided is a method involving: (i) providing an operant conditioning protocol effective to produce targeted neural plasticity (TNP) in a primary targeted central nervous system (CNS) pathway of a subject; and (ii) administering the operant conditioning protocol to the subject to elicit TNP in the primary targeted CNS pathway and to elicit generalized neural plasticity (GNP) in one or more other CNS pathway. The elicitation of the GNP in the one or more other CNS pathway serves to restore or improve a nervous system function of the subject. Provided is a device comprising a nerve stimulation-electromyographic recording component and a controller for operating the nerve stimulation-electromyographic recording component in accordance with an operant conditioning protocol.

Abstract translation: 本发明提供了用于恢复或改善受试者的神经系统功能的方法，装置和系统。 提供了一种方法，其包括：（i）提供有效地在受试者的主要靶向中枢神经系统（CNS）途径中产生靶向神经可塑性（TNP）的操作调节方案; 和（ii）向受试者施用操作调节方案以在主要靶向CNS途径中引发TNP，并在一个或多个其它CNS途径中引发广义神经可塑性（GNP）。 在一种或多种其他CNS途径中引发GNP用于恢复或改善受试者的神经系统功能。 提供了包括神经刺激 - 肌电记录部件和根据操作调节方案来操作神经刺激 - 肌电图记录部件的控制器的装置。

公开(公告)号：US08862236B2

公开(公告)日：2014-10-14

申请号：US13958181

申请日：2013-08-02

Applicant: Health Research, Inc.

Inventor： Jonathan R. Wolpaw ,  Gerwin Schalk ,  Aiko K. Thompson ,  Peter Brunner ,  Xiang Yang Chen ,  Dennis J. McFarland

IPC: A61N1/00 ,  A61N1/36

CPC classification number: A61N1/36014 ,  A61B5/0488 ,  A61B5/0492 ,  A61B5/4848 ,  A61B5/6828 ,  A61B5/742 ,  A61B2562/046 ,  A61N1/0456 ,  A61N1/0476 ,  A61N1/36003 ,  A61N1/36025 ,  A61N1/36082 ,  A61N1/36103

Abstract: The present invention provides methods, devices, and systems for restoring or improving nervous system function of a subject. Provided is a method involving: (i) providing an operant conditioning protocol effective to produce targeted neural plasticity (TNP) in a primary targeted central nervous system (CNS) pathway of a subject; and (ii) administering the operant conditioning protocol to the subject to elicit TNP in the primary targeted CNS pathway and to elicit generalized neural plasticity (GNP) in one or more other CNS pathway. The elicitation of the GNP in the one or more other CNS pathway serves to restore or improve a nervous system function of the subject. Provided is a device comprising a nerve stimulation-electromyographic recording component and a controller for operating the nerve stimulation-electromyographic recording component in accordance with an operant conditioning protocol.

Abstract translation: 本发明提供了用于恢复或改善受试者的神经系统功能的方法，装置和系统。 提供了一种方法，其包括：（i）提供有效地在受试者的主要靶向中枢神经系统（CNS）途径中产生靶向神经可塑性（TNP）的操作调节方案; 和（ii）向受试者施用操作调节方案以在主要靶向CNS途径中引发TNP，并在一个或多个其它CNS途径中引发广义神经可塑性（GNP）。 在一种或多种其他CNS途径中引发GNP用于恢复或改善受试者的神经系统功能。 提供了包括神经刺激 - 肌电记录部件和根据操作调节方案来操作神经刺激 - 肌电图记录部件的控制器的装置。