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公开(公告)号：US11702452B2
公开(公告)日：2023-07-18
申请号：US17517103
申请日：2021-11-02
Applicant: Genentech, Inc.
Inventor： Filip Petronijevic , Ngiap-Kie Lim , Nicholas Wong , Allen Hong , Haiyun Hou , Xin Linghu , Francis Gosselin
Abstract: Methods for making an arylomycin ring of formula t
or salts or solvates thereof, wherein R, R1, R2, R3, R4, R5, R6, R7, R8, R9, R5, R10 and Pg1 are as defined herein.-
公开(公告)号：US11066389B2
公开(公告)日：2021-07-20
申请号：US16718602
申请日：2019-12-18
Applicant: Genentech, Inc.
Inventor： Jinguang Lin , Alexandra Chestakova , Wei Gu , Hans Iding , Jing Li , Xin Linghu , Patrik Meier , Chunbo Sha , Jeffrey Stults , Youchu Wang , Haiming Zhang , Jianqian Zhang , Tao Zhang
IPC: C07D401/14 , C07D401/04 , A61P35/00 , A61P25/00 , A61P29/00 , C12P17/16
Abstract: The present invention provides a process for the manufacture of a compound of formula VIIIa and salts forms of VIIIa where Rc is an aryl sulfonic acid
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公开(公告)号：US20190270695A1
公开(公告)日：2019-09-05
申请号：US16415612
申请日：2019-05-17
Applicant: Genentech, Inc.
Inventor： Stephan Bachmann , Serena Maria Fantasia , Michael Jansen , Stefan Koenig , Xin Linghu , Sebastian Rieth , Nathaniel L. Segraves , Andreas Zogg
IPC: C07C213/00 , A61K47/68 , C07D498/04 , C07D498/18 , C07K16/12 , C07C213/02 , C07C201/12
Abstract: Processes are described for the preparation of F-benzoxazinorifamycin I: and intermediates for conjugation with an antibody.
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公开(公告)号：US11192924B2
公开(公告)日：2021-12-07
申请号：US16581116
申请日：2019-09-24
Applicant: Genentech, Inc.
Inventor： Filip Petronijevic , Ngiap-Kie Lim , Nicholas Wong , Allen Hong , Haiyun Hou , Xin Linghu , Francis Gosselin
Abstract: Methods for making an arylomycin ring of formula t or salts or solvates thereof, wherein R, R1, R2, R3, R4, R5, R6, R7, R8, R9, R5, R10 and Pg1 are as defined herein.
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公开(公告)号：US11098028B2
公开(公告)日：2021-08-24
申请号：US16535752
申请日：2019-08-08
Applicant: Genentech, Inc.
Inventor： Jinguang Lin , Alexandra Chestakova , Wei Gu , Hans Iding , Jing Li , Xin Linghu , Patrik Meier , Chunbo Sha , Jeffrey Stults , Youchu Wang , Haiming Zhang , Jianqian Zhang , Tao Zhang
IPC: C07D401/14 , C07D401/04 , C12P17/16 , A61P35/00 , A61P25/00 , A61P29/00
Abstract: The present invention provides a process for the manufacture of a compound of formula VIIIa and salts forms of VIIIa where Rc is an aryl sulfonic acid
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Patent Agency Ranking
公开(公告)号：US10689325B2
公开(公告)日：2020-06-23
申请号：US16415612
申请日：2019-05-17
Applicant: Genentech, Inc.
Inventor： Stephan Bachmann , Serena Maria Fantasia , Michael Jansen , Stefan Koenig , Xin Linghu , Sebastian Rieth , Nathaniel L. Segraves , Andreas Zogg
IPC: C07D498/22 , C07C213/00 , C07C201/12 , C07C213/02 , C07K16/12 , C07D498/04 , A61K47/68 , C07D498/18 , A61K39/00
Abstract: Processes are described for the preparation of F-benzoxazinorifamycin I: and intermediates for conjugation with an antibody.
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公开(公告)号：US10336683B2
公开(公告)日：2019-07-02
申请号：US15448894
申请日：2017-03-03
Applicant: Genentech, Inc.
Inventor： Stephan Bachmann , Serena Maria Fantasia , Michael Jansen , Stefan Koenig , Xin Linghu , Sebastian Rieth , Nathaniel L. Segraves , Andreas Zogg
IPC: C07D498/22 , C07C213/00 , C07D498/18 , C07K16/12 , C07C201/12 , C07C213/02 , C07D498/04 , A61K47/68 , A61K39/00
Abstract: Processes are described for the preparation of F-benzoxazinorifamycin I: and intermediates for conjugation with an antibody.
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公开(公告)号：US20180134685A1
公开(公告)日：2018-05-17
申请号：US15866899
申请日：2018-01-10
Applicant: Genentech, Inc.
Inventor： Jinguang Lin , Alexandra Chestakova , Wei Gu , Hans Iding , Jing Li , Xin Linghu , Patrik Meier , Chunbo Sha , Jeffrey Stults , Youchu Wang , Haiming Zhang , Jianqian Zhang , Tao Zhang
IPC: C07D401/14 , C07D401/04 , C12P17/16
CPC classification number: C07D401/14 , A61P25/00 , A61P29/00 , A61P35/00 , C07D401/04 , C12P17/165
Abstract: The present invention provides a process for the manufacture of a compound of formula VIIIa and salts forms of VIIIa where Rc is an aryl sulfonic acid
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公开(公告)号：US20170252457A1
公开(公告)日：2017-09-07
申请号：US15448894
申请日：2017-03-03
Applicant: Genentech, Inc.
Inventor： Stephan Bachmann , Serena Maria Fantasia , Michael Jansen , Stefan Koenig , Xin Linghu , Sebastian Rieth , Nathaniel L. Segraves , Andreas Zogg
IPC: A61K47/48 , C07K16/12 , C07D498/18 , C07C213/00 , C07K19/00
CPC classification number: C07C213/00 , A61K47/6803 , A61K47/6835 , A61K2039/505 , C07C201/12 , C07C213/02 , C07D498/04 , C07D498/18 , C07K16/1267 , C07K16/1271 , C07K2317/77 , C07C205/37 , C07C215/78
Abstract: Processes are described for the preparation of F-benzoxazinorifamycin I: and intermediates for conjugation with an antibody.
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公开(公告)号：US20170022183A1
公开(公告)日：2017-01-26
申请号：US15285781
申请日：2016-10-05
Applicant: Genentech, Inc.
Inventor： Jinguang Lin , Alexandra Chestakova , Wei Gu , Hans Iding , Jing Li , Xin Linghu , Patrik Meier , Chunbo Sha , Jeffrey Stults , Youchu Wang , Haiming Zhang , Jianqian Zhang , Tao Zhang
IPC: C07D401/14 , C12P17/16 , C07D401/04
CPC classification number: C07D401/14 , A61P25/00 , A61P29/00 , A61P35/00 , C07D401/04 , C12P17/165
Abstract: The present invention provides a process for the manufacture of a compound of formula VIIIa and salts forms of VIIIa where Rc is an aryl sulfonic acid
Abstract translation: 本发明提供了制备式（Ⅷa）化合物和（Ⅷa）盐形式的方法，其中Rc是芳基磺酸。
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