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公开(公告)号：US09453079B2
公开(公告)日：2016-09-27
申请号：US14292461
申请日：2014-05-30
Applicant: Genentech, Inc.
Inventor： Jasvinder Atwal , Yongmei Chen , Cecilia Pui Chi Chiu , Robert A. Lazarus , Weiru Wang , Ryan J. Watts , Yan Wu , Yingnan Zhang
IPC: C07K16/18 , A61K39/395 , C07K16/40 , A61K47/48 , G01N33/573 , A61K39/00
CPC classification number: C07K16/40 , A61K39/3955 , A61K47/6871 , A61K2039/505 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12P21/005 , G01N33/573
Abstract: The invention provides antibodies to specific neural proteins and methods of using the same.
Abstract translation: 本发明提供了针对特定神经蛋白的抗体及其使用方法。
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公开(公告)号：US20150126448A1
公开(公告)日：2015-05-07
申请号：US14316621
申请日：2014-06-26
Applicant: Genentech, Inc.
Inventor： Daniel K. Kirchhofer , Robert A. Lazarus , Xiaoyi Yao
CPC classification number: A61K38/10 , C07K7/08 , C07K14/4753 , G01N33/57438 , G01N33/6863 , G01N33/6872 , G01N33/74 , G01N2333/4753 , G01N2500/02 , G01N2500/04
Abstract: The invention provides methods and compositions for modulating the HGF/c-met signaling pathway, in particular by regulating binding of HGF β chain to c-met.
Abstract translation: 本发明提供调节HGF / c-met信号通路的方法和组合物，特别是通过调节HGF和bgr的结合; 链到c-met。
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公开(公告)号：US20190078160A1
公开(公告)日：2019-03-14
申请号：US15958696
申请日：2018-04-20
Applicant: Genentech, Inc.
Inventor： Amy Dressen , David B. Iaea , Moulay Hicham Alaoui Ismaili , Janet K. Jackman , Robert A. Lazarus , Kelly Loyet , Henry R. Maun , Brian L. Yaspan , Tangsheng Yi , Joseph R. Arron , Hilda Y. Hernandez-Barry
IPC: C12Q1/6883
Abstract: Provided herein are methods of treating a subject, methods of predicting the response of a subject and selecting a subject suffering from a disease associated with KLK5, such as asthma or Netherton Syndrome. In particular, provided herein are uses of KLK5 antagonists for the treatment or diagnosis of asthma or Netherton Syndrome, such as an antibody or an Fc fusion polypeptide as well as pharmaceutical formulations comprising the same.
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公开(公告)号：US20190054138A1
公开(公告)日：2019-02-21
申请号：US15921827
申请日：2018-03-15
Applicant: Genentech, Inc.
Inventor： Daniel K. Kirchhofer , Robert A. Lazarus , Xiaoyi Yao
IPC: A61K38/10 , G01N33/68 , G01N33/574 , C07K7/08 , C07K14/475 , G01N33/74
Abstract: The invention provides methods and compositions for modulating the HGF/c-met signaling pathway, in particular by regulating binding of HGF β chain to c-met.
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公开(公告)号：US09879094B2
公开(公告)日：2018-01-30
申请号：US15234649
申请日：2016-08-11
Applicant: Genentech, Inc.
Inventor： Jasvinder Atwal , Yongmei Chen , Cecilia Pui Chi Chiu , Robert A. Lazarus , Weiru Wang , Ryan J. Watts , Yan Wu , Yingnan Zhang
IPC: C07H21/04 , C07K16/18 , C12P21/08 , C07K16/40 , A61K39/395 , G01N33/573 , C12P21/00 , A61K47/68 , A61K39/00
CPC classification number: C07K16/40 , A61K39/3955 , A61K47/6871 , A61K2039/505 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12P21/005 , G01N33/573
Abstract: The invention provides antibodies to specific neural proteins and methods of using the same.
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Patent Agency Ranking
公开(公告)号：US20170106042A1
公开(公告)日：2017-04-20
申请号：US15162372
申请日：2016-05-23
Applicant: Genentech, Inc.
Inventor： Daniel K. Kirchhofer , Robert A. Lazarus , Xiaoyi Yao
IPC: A61K38/10 , C07K14/475 , G01N33/68 , C07K7/08
CPC classification number: A61K38/10 , C07K7/08 , C07K14/4753 , G01N33/57438 , G01N33/6863 , G01N33/6872 , G01N33/74 , G01N2333/4753 , G01N2500/02 , G01N2500/04
Abstract: The invention provides methods and compositions for modulating the HGF/c-met signaling pathway, in particular by regulating binding of HGF β chain to c-met.
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公开(公告)号：US10562946B2
公开(公告)日：2020-02-18
申请号：US15320736
申请日：2015-06-19
Applicant: Genentech, Inc.
Inventor： Robert A. Lazarus , Henry R. Maun
Abstract: Provided are novel, non-naturally occurring chagasin scaffold proteins derived from chagasin or chagasin-like protease inhibitor proteins. Also provided are libraries of non-naturally occurring chagasin scaffold proteins and methods of using such libraries to generate non-naturally occurring chagasin scaffold proteins that specifically bind to a target ligand. The present invention further provides methods of using non-naturally occurring chagasin protein scaffold that bind to a target ligand, including diagnostic and therapeutic compositions and methods. The invention also provides novel non-naturally occurring chagasin scaffold proteins that specifically bind low density lipoprotein receptor-related protein 6 (LRP6) and novel non-naturally occurring chagasin scaffold proteins that specifically bind vascular endothelial growth factor (VEGF).
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公开(公告)号：US09624269B2
公开(公告)日：2017-04-18
申请号：US14948173
申请日：2015-11-20
Applicant: GENENTECH, INC.
Inventor： Robert A. Lazarus , Yingnan Zhang , Weiru Wang
CPC classification number: C07K7/08 , A61K38/00 , C07K16/38 , G01N33/6896 , Y02A50/465
Abstract: The invention provides peptide inhibitors of BACE1 that bind to the active site in a noncanonical fashion, and methods of use thereof.
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公开(公告)号：US20160304563A1
公开(公告)日：2016-10-20
申请号：US14948173
申请日：2015-11-20
Applicant: Genentech, Inc.
Inventor： Robert A. Lazarus , Yingnan Zhang , Weiru Wang
IPC: C07K7/08
CPC classification number: C07K7/08 , A61K38/00 , C07K16/38 , G01N33/6896 , Y02A50/465
Abstract: The invention provides peptide inhibitors of BACE1 that bind to the active site in a noncanonical fashion, and methods of use thereof.
Abstract translation: 本发明提供了以非规范方式结合活性位点的BACE1肽抑制剂及其使用方法。
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公开(公告)号：US09193766B2
公开(公告)日：2015-11-24
申请号：US14351525
申请日：2012-10-12
Applicant: GENENTECH, INC.
Inventor： Robert A. Lazarus , Yingnan Zhang , Weiru Wang
CPC classification number: C07K7/08 , A61K38/00 , C07K16/38 , G01N33/6896 , Y02A50/465
Abstract: The invention provides peptide inhibitors of BACE1 that bind to the active site in a noncanonical fashion, and methods of use thereof.
Abstract translation: 本发明提供了以非规范方式结合活性位点的BACE1肽抑制剂及其使用方法。
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