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公开(公告)号：US20200164077A1
公开(公告)日：2020-05-28
申请号：US16460957
申请日：2019-07-02
Applicant: CITY OF HOPE
Inventor： John C. Williams , Cindy Zer , Kendra N. Avery , Ulrich Rodeck , Joshua M. Donaldson , Csaba Kari
Abstract: In one embodiment, a masked monoclonal antibody (mAb) is provided, the mAb, encoded by a nucleic acid sequence or an amino acid sequence molecule comprising a signal sequence, a masking epitope sequence, a linker sequence that is cleavable by a protease specific to a target tissue; and an antibody or a functional fragment thereof. In another embodiment, a masked monoclonal antibody (mAb) is provided, which includes a therapeutic mAb and a mask, the mask comprising protein A and protein L attached by a protease cleavable linker.
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公开(公告)号：US11246942B2
公开(公告)日：2022-02-15
申请号：US15614468
申请日：2017-06-05
Applicant: City of Hope
Inventor： John C. Williams , David A. Horne , Yuelong Ma , Heng Wei Chang , Joshua Michael Donaldson , Cindy Zer , Krzysztof Bzymek , Kendra Nicole Avery , Jun Xie
IPC: C07K16/18 , C07K16/28 , C07K16/32 , A61K38/08 , A61K39/395 , A61K47/06 , A61K51/10 , B82Y5/00 , A61K38/12 , A61K47/68 , A61K47/66
Abstract: Antibodies and meditopes that bind to the antibodies are provided, as well as complexes, compositions and combinations containing the meditopes and antibodies, and methods of producing, using, testing, and screening the same, including therapeutic and diagnostic methods and uses.
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公开(公告)号：US20180193479A1
公开(公告)日：2018-07-12
申请号：US15614468
申请日：2017-06-05
Applicant: City of Hope
Inventor： John C. Williams , David A. Horne , Yuelong Ma , Heng Wei Chang , Joshua Michael Donaldson , Cindy Zer , Krzysztof Bzymek , Kendra Nicole Avery , Jun Xie
CPC classification number: A61K47/6811 , A61K47/66 , A61K47/6813 , A61K47/6851 , A61K47/6877 , A61K47/6897 , A61K51/1087 , B82Y5/00 , C07K16/18 , C07K16/2863 , C07K16/32 , C07K2299/00 , C07K2317/34 , C07K2317/40 , C07K2317/55 , C07K2317/567 , C07K2317/622 , C07K2317/92
Abstract: Antibodies and meditopes that bind to the antibodies are provided, as well as complexes, compositions and combinations containing the meditopes and antibodies, and methods of producing, using, testing, and screening the same, including therapeutic and diagnostic methods and uses.
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公开(公告)号：US09428553B2
公开(公告)日：2016-08-30
申请号：US13764762
申请日：2013-02-11
Applicant: City of Hope
Inventor： John C. Williams , Cindy Zer , Krzysztof Bzymek , Kendra Nicole Avery
CPC classification number: C07K14/001 , A61K47/48346 , A61K47/48746 , A61K47/66 , A61K47/6897 , B82Y5/00 , C07K16/2863 , C07K16/32 , C07K2299/00 , C07K2317/34 , C07K2317/55 , C07K2317/567 , C07K2317/622 , C07K2317/92
Abstract: Antibodies and meditopes that bind to the antibodies are provided, as well as complexes, compositions and combinations containing the meditopes and antibodies, and methods of producing, using, testing, and screening the same, including therapeutic and diagnostic methods and uses.
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公开(公告)号：US20140113348A1
公开(公告)日：2014-04-24
申请号：US13764762
申请日：2013-02-11
Applicant: CITY OF HOPE
Inventor： John C. Williams , Cindy Zer , Krzysztof Bzymek , Kendra Nicole Avery
IPC: C07K14/00
CPC classification number: C07K14/001 , A61K47/48346 , A61K47/48746 , A61K47/66 , A61K47/6897 , B82Y5/00 , C07K16/2863 , C07K16/32 , C07K2299/00 , C07K2317/34 , C07K2317/55 , C07K2317/567 , C07K2317/622 , C07K2317/92
Abstract: Antibodies and meditopes that bind to the antibodies are provided, as well as complexes, compositions and combinations containing the meditopes and antibodies, and methods of producing, using, testing, and screening the same, including therapeutic and diagnostic methods and uses.
Abstract translation: 提供了与抗体结合的抗体和沉默剂，以及包含中间体和抗体的复合物，组合物和组合，以及生产，使用，测试和筛选其中的方法，包括治疗和诊断方法和用途。
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Patent Agency Ranking
公开(公告)号：US20230085485A1
公开(公告)日：2023-03-16
申请号：US17660603
申请日：2022-04-25
Applicant: CITY OF HOPE , THOMAS JEFFERSON UNIVERSITY
Inventor： John C. Williams , Cindy Zer , Kendra N. Avery , Ulrich Rodeck , Joshua M. Donaldson , Csaba Kari
Abstract: In one embodiment, a masked monoclonal antibody (mAb) is provided, the mAb, encoded by a nucleic acid sequence or an amino acid sequence molecule comprising a signal sequence, a masking epitope sequence, a linker sequence that is cleavable by a protease specific to a target tissue; and an antibody or a functional fragment thereof. In another embodiment, a masked monoclonal antibody (mAb) is provided, which includes a therapeutic mAb and a mask, the mask comprising protein A and protein L attached by a protease cleavable linker.
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公开(公告)号：US20230001003A1
公开(公告)日：2023-01-05
申请号：US17556863
申请日：2021-12-20
Applicant: City of Hope
Inventor： John C. Williams , David A. Horne , Yuelong Ma , Heng Wei Chang , Joshua Michael Donaldson , Cindy Zer , Krzysztof Bzymek , Kendra Nicole Avery , Jun Xie
Abstract: Antibodies and meditopes that bind to the antibodies are provided, as well as complexes, compositions and combinations containing the meditopes and antibodies, and methods of producing, using, testing, and screening the same, including therapeutic and diagnostic methods and uses.
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公开(公告)号：US11311622B2
公开(公告)日：2022-04-26
申请号：US16460957
申请日：2019-07-02
Applicant: CITY OF HOPE , Thomas Jefferson University
Inventor： John C. Williams , Cindy Zer , Kendra N. Avery , Ulrich Rodeck , Joshua M. Donaldson , Csaba Kari
Abstract: In one embodiment, a masked monoclonal antibody (mAb) is provided, the mAb, encoded by a nucleic acid sequence or an amino acid sequence molecule comprising a signal sequence, a masking epitope sequence, a linker sequence that is cleavable by a protease specific to a target tissue; and an antibody or a functional fragment thereof. In another embodiment, a masked monoclonal antibody (mAb) is provided, which includes a therapeutic mAb and a mask, the mask comprising protein A and protein L attached by a protease cleavable linker.
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公开(公告)号：US10357571B2
公开(公告)日：2019-07-23
申请号：US14949648
申请日：2015-11-23
Applicant: City of Hope , Thomas Jefferson University
Inventor： John C. Williams , Cindy Zer , Kendra N. Avery , Ulrich Rodeck , Joshua M. Donaldson , Csaba Kari
Abstract: In one embodiment, a masked monoclonal antibody (mAb) is provided, the mAb, encoded by a nucleic acid sequence or an amino acid sequence molecule comprising a signal sequence, a masking epitope sequence, a linker sequence that is cleavable by a protease specific to a target tissue; and an antibody or a functional fragment thereof. In another embodiment, a masked monoclonal antibody (mAb) is provided, which includes a therapeutic mAb and a mask, the mask comprising protein A and protein L attached by a protease cleavable linker.
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公开(公告)号：US09669108B2
公开(公告)日：2017-06-06
申请号：US14453586
申请日：2014-08-06
Applicant: City of Hope
Inventor： John C. Williams , David A. Horne , Yuelong Ma , Heng Wei Chang , Joshua M. Donaldson , Cindy Zer , Krzysztof Bzymek , Kendra N. Avery , Jun Xie
IPC: C07K16/18 , C07K7/00 , A61K47/48 , A61K38/00 , A61K39/00 , A61K51/10 , C07K16/28 , C07K16/32 , B82Y5/00
CPC classification number: A61K47/6811 , A61K47/66 , A61K47/6813 , A61K47/6851 , A61K47/6877 , A61K47/6897 , A61K51/1087 , B82Y5/00 , C07K16/18 , C07K16/2863 , C07K16/32 , C07K2299/00 , C07K2317/34 , C07K2317/40 , C07K2317/55 , C07K2317/567 , C07K2317/622 , C07K2317/92
Abstract: Antibodies and meditopes that bind to the antibodies are provided, as well as complexes, compositions and combinations containing the meditopes and antibodies, and methods of producing, using, testing, and screening the same, including therapeutic and diagnostic methods and uses.
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