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    Compact automated cell counter
    3.
    发明授权
    Compact automated cell counter 有权

    公开(公告)号：US09850517B2

    公开(公告)日：2017-12-26

    申请号：US14039682

    申请日：2013-09-27

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： Tom McCollum ,  Paul Patt ,  Frank Shen ,  Daniel Y. Chu ,  Don Flory ,  Mike Griffin ,  Xin Heng ,  Eli Hefner

    IPC: C12Q1/06 ,  G01N15/14 ,  G02B21/34 ,  G02B21/00

    CPC classification number: C12Q1/06 ,  G01N15/1434 ,  G02B21/0008 ,  G02B21/34

    Abstract: Biological cells in a liquid suspension are counted in an automated cell counter that focuses an image of the suspension on a digital imaging sensor that contains at least 4,000,000 pixels each having an area of 2×2 μm or less and that images a field of view of at least 3 mm2. The sensor enables the counter to compress the optical components into an optical path of less than 20 cm in height when arranged vertically with no changes in direction of the optical path as a whole, and the entire instrument has a footprint of less than 300 cm2. Activation of the light source, automated focusing of the sensor image, and digital cell counting are all initiated by the simple insertion of the sample holder into the instrument. The suspension is placed in a sample chamber in the form of a slide that is shaped to ensure proper orientation of the slide in the cell counter.

    METHODS FOR POLYMERASE CHAIN REACTION COPY NUMBER VARIATION ASSAYS
    4.
    发明申请
    METHODS FOR POLYMERASE CHAIN REACTION COPY NUMBER VARIATION ASSAYS 审中-公开
    用于聚合酶链反应的方法复制数变异性测定

    公开(公告)号：US20140162266A1

    公开(公告)日：2014-06-12

    申请号：US14097923

    申请日：2013-12-05

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： Niels Klitgord ,  John Regan ,  Svilen Tzonev ,  Eli Hefner ,  Jennifer R. Berman

    IPC: C12Q1/68

    CPC classification number: C12Q1/6851 ,  C12Q2537/16 ,  C12Q2563/159

    Abstract: This disclosure provides methods for measuring the copy number for highly amplified and/or abundant genomic loci. Recognized herein is a need for methods for determining nucleic acid copy number, particularly in instances where one locus to be quantified (i.e., the target) is relatively more abundant than a locus of known abundance (i.e., the reference). In some cases, the method involves combining a query nucleic acid sample with a diluting nucleic acid sample and measuring the relative copy number of a target sequence compared with a reference sequence in the combined sample.

    Abstract translation: 本公开提供了用于测量高度扩增和/或丰富的基因组基因座的拷贝数的方法。 本文认识到需要用于确定核酸拷贝数的方法，特别是在一个待定量的位点（即目标）相对于已知丰度的基因座（即参考文献）相对更丰富的情况下。 在一些情况下，该方法包括将查询核酸样品与稀释的核酸样品组合，并测量与组合样品中的参考序列相比的靶序列的相对拷贝数。

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