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公开(公告)号：US09453048B2
公开(公告)日：2016-09-27
申请号：US14419975
申请日：2013-08-06
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Robert M. Borzilleri , Heidi L. Perez , Donna D. Wei , Kyoung S. Kim
IPC: A61K38/06 , C07K5/09 , C07D401/12 , C07D207/16 , C07K5/062 , C07K5/083 , A61K45/06
CPC classification number: C07K5/0815 , A61K38/06 , A61K45/06 , C07D207/16 , C07D401/12 , C07K5/06026 , C07K5/0806
Abstract: There are disclosed compounds of formula (I) that modulate the activity of inhibitors of apoptosis (IAPs), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing said compounds.
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公开(公告)号：US20130338081A1
公开(公告)日：2013-12-19
申请号：US13921467
申请日：2013-06-19
Applicant: Bristol-Myers Squibb Company
Inventor： Robert M. Borzilleri , Heidi L. Perez , Erik M. Stang , Kyoung S. Kim
CPC classification number: A61K38/08 , A61K45/06 , C07D401/04 , C07D401/12 , C07D401/14 , C07D413/14 , C07K7/02
Abstract: There are disclosed compounds that modulate the activity of inhibitors of apoptosis (IAPs), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.
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公开(公告)号：US09738630B2
公开(公告)日：2017-08-22
申请号：US15037081
申请日：2014-11-18
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Kyoung S. Kim , Liping Zhang , Ashok Vinayak Purandare , Steven P. Seitz
IPC: C07D405/12 , C07D401/14 , C07D413/14 , A61K31/4725 , C07D407/14 , C07D417/14 , A61K45/06 , A61K31/496 , A61K31/5377 , A61K31/541 , C07D405/14
CPC classification number: C07D405/12 , A61K31/4725 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D401/14 , C07D405/14 , C07D407/14 , C07D413/14 , C07D417/14 , Y02A50/411 , Y02A50/414 , A61K2300/00
Abstract: There are disclosed compounds that are inhibitors of EZH2, pharmaceutical compositions containing said compounds and methods of treating hyperproliferative, inflammatory, infectious, and immunoregulatory disorders and diseases, utilizing the compounds of the invention.
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公开(公告)号：US20160176871A1
公开(公告)日：2016-06-23
申请号：US14977709
申请日：2015-12-22
Applicant: Bristol-Myers Squibb Company
Inventor： Brian E. Fink , Yufen Zhao , Robert M. Borzilleri , Liping Zhang , Kyoung S. Kim , Muthoni G. Kamau , Andrew J. Tebben
IPC: C07D471/04 , A61K31/506 , A61K31/4709 , A61K31/501 , A61K31/4985 , A61K31/5377 , A61K31/496 , A61K31/541 , A61K31/437 , C07D487/04
CPC classification number: C07D471/04 , A61K31/437 , A61K31/4709 , A61K31/496 , A61K31/4985 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K31/541 , C07D487/04 , Y02P20/582
Abstract: The invention relates generally to compounds that modulate the activity of TGFβR-1 and TGFβR-2, pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.
Abstract translation: 本发明一般涉及调节TGF-bgr R-1和TGF-bgr R-2的活性的化合物，含有所述化合物的药物组合物和使用本发明化合物治疗增殖性疾病和失调性细胞凋亡障碍（例如癌症）的方法 。
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公开(公告)号：US09708316B2
公开(公告)日：2017-07-18
申请号：US14977709
申请日：2015-12-22
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Brian E. Fink , Yufen Zhao , Robert M. Borzilleri , Liping Zhang , Kyoung S. Kim , Muthoni G. Kamau , Andrew J. Tebben , Yong Zhang , Andrew F. Donnell
IPC: A61K31/4709 , A61K31/501 , C07D487/04 , C07D471/04 , A61K31/5377 , A61K31/437 , A61K31/496 , A61K31/4985 , A61K31/506 , A61K31/541
CPC classification number: C07D471/04 , A61K31/437 , A61K31/4709 , A61K31/496 , A61K31/4985 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K31/541 , C07D487/04 , Y02P20/582
Abstract: The invention relates generally to compounds that modulate the activity of TGFβR-1 and TGFβR-2, pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.
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Patent Agency Ranking
公开(公告)号：US20160297806A1
公开(公告)日：2016-10-13
申请号：US15037081
申请日：2014-11-18
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Kyoung S. Kim , Liping Zhang , Ashok Vinandare Purandara , Steven P. Seitz
IPC: C07D405/12 , A61K31/5377 , A61K31/496 , C07D417/14 , C07D405/14 , A61K45/06 , A61K31/541
CPC classification number: C07D405/12 , A61K31/4725 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D401/14 , C07D405/14 , C07D407/14 , C07D413/14 , C07D417/14 , Y02A50/411 , Y02A50/414 , A61K2300/00
Abstract: There are disclosed compounds that are inhibitors of EZH2, pharmaceutical compositions containing said compounds and methods of treating hyperproliferative, inflammatory, infectious, and immunoregulatory disorders and diseases, utilizing the compounds of the invention.
Abstract translation: 公开了作为EZH2抑制剂的化合物，含有所述化合物的药物组合物和利用本发明化合物治疗过度增殖，炎症，感染和免疫调节性疾病和疾病的方法。
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公开(公告)号：US20150238558A1
公开(公告)日：2015-08-27
申请号：US14432517
申请日：2013-10-01
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Kyoung S. Kim , Liping Zhang , Donna D. Wei
CPC classification number: A61K38/08 , A61K38/00 , A61K45/06 , C07K5/0806 , C07K7/06
Abstract: There are disclosed compounds that modulate the activity of inhibitors of apoptosis (IAPs), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.
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公开(公告)号：US20150164974A1
公开(公告)日：2015-06-18
申请号：US14413791
申请日：2013-07-10
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Kyoung S. Kim
CPC classification number: A61K38/06 , A61K45/06 , C07F7/0812 , C07K5/0806
Abstract: There are disclosed compounds that modulate the activity of inhibitors of apoptosis (IAPs), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.
Abstract translation: 公开了利用本发明化合物调节凋亡抑制剂（IAP）的活性的化合物，含有所述化合物的药物组合物和治疗增殖性疾病和失调性细胞凋亡障碍的疾病的方法。
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公开(公告)号：US09637518B2
公开(公告)日：2017-05-02
申请号：US14903306
申请日：2014-07-10
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Kyoung S. Kim , Liping Zhang , Erik M. Stang
CPC classification number: C07K5/0806 , A61K38/00 , A61K38/06 , A61K45/06 , C07K14/4747 , C07K14/8139
Abstract: There are disclosed compounds that modulate the activity of inhibitors of apoptosis (IAPs), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.
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公开(公告)号：US09345740B2
公开(公告)日：2016-05-24
申请号：US14413791
申请日：2013-07-10
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Kyoung S. Kim
CPC classification number: A61K38/06 , A61K45/06 , C07F7/0812 , C07K5/0806
Abstract: There are disclosed compounds that modulate the activity of inhibitors of apoptosis (IAPs), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.
Abstract translation: 公开了利用本发明化合物调节凋亡抑制剂（IAP）的活性的化合物，含有所述化合物的药物组合物和治疗增殖性疾病和失调性细胞凋亡障碍的疾病的方法。
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