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公开(公告)号：US20150191490A1
公开(公告)日：2015-07-09
申请号：US14663286
申请日：2015-03-19
Applicant: Array BioPharma Inc.
Inventor： Jeremy Hans , Eli M. Wallace , Qian Zhao , Shelley Allen , Ellen Laird , Joseph P. Lyssikatos , John E. Robinson , Christopher P. Corrette , Robert Kirk Delisle , Walter C. Voegtli
IPC: C07D513/04 , C07D285/12 , C07D417/04 , C07D419/04 , C07D497/04
CPC classification number: C07D513/04 , C07D285/12 , C07D417/04 , C07D417/14 , C07D419/04 , C07D471/04 , C07D487/04 , C07D495/04 , C07D497/04 , C07F9/65395
Abstract: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.
Abstract translation: 本发明涉及有丝分裂驱动蛋白抑制剂，特别是KSP，以及制备这些抑制剂的方法。 本发明还提供包含本发明抑制剂的药物组合物和利用抑制剂和药物组合物治疗和预防各种疾病的方法。
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公开(公告)号：US20140018399A1
公开(公告)日：2014-01-16
申请号：US14031958
申请日：2013-09-19
Applicant: Array BioPharma Inc.
Inventor： Jeremy Hans , Eli M. Wallace , Qian Zhao , Shelley Allen , Ellen Laird , Joseph P. Lyssikatos , John E. Robinson , Christopher P. Corrette , Robert Kirk DeLisle , Walter C. Voegtli
IPC: C07D285/12 , C07D417/04
CPC classification number: C07D513/04 , C07D285/12 , C07D417/04 , C07D417/14 , C07D419/04 , C07D471/04 , C07D487/04 , C07D495/04 , C07D497/04 , C07F9/65395
Abstract: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.
Abstract translation: 本发明涉及有丝分裂驱动蛋白抑制剂，特别是KSP，以及制备这些抑制剂的方法。 本发明还提供包含本发明抑制剂的药物组合物和利用抑制剂和药物组合物治疗和预防各种疾病的方法。
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![4,6-SUBSTITUTED-PYRAZOLO[1,5-a]PYRAZINES AS JANUS KINASE INHIBITORS](/abs-image/US/2019/06/13/US20190177328A1/abs.jpg.150x150.jpg)
公开(公告)号：US20190177328A1
公开(公告)日：2019-06-13
申请号：US16212493
申请日：2018-12-06
Applicant: Array BioPharma Inc. , Celgene Corporation
Inventor： Shelley Allen , Mark Laurence Boys , Mark J. Chicarelli , Jay Bradford Fell , John P. Fischer , John Gaudino , Erik James Hicken , Ronald Jay Hinklin , Christopher F. Kraser , Ellen Laird , John E. Robinson , Tony P. Tang , Laurence E. Burgess , Robert Andrew Rieger , Jed Pheneger , Yoshitaka Satoh , Katerina Leftheris , Raj K. Raheja , Brydon L. Bennett
IPC: C07D487/04 , A61K45/06 , A61K31/4985 , A61K31/5377
Abstract: Compounds of Formula I: and stereoisomers and pharmaceutically acceptable salts and solvates thereof in which R1, R2, R3 and R4 have the meanings given in the specification, are inhibitors of one or more JAK kinases and are useful in the treatment of JAK kinase-associated diseases and disorders, such as autoimmune diseases, inflammatory diseases, rejection of transplanted organs, tissues and cells, as well as hematologic disorders and malignancies and their co-morbidities.
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![4,6-substituted-pyrazolo[1,5-a]pyrazines as janus kinase inhibitors](/abs-image/US/2019/01/29/US10189845B2/abs.jpg.150x150.jpg)
公开(公告)号：US10189845B2
公开(公告)日：2019-01-29
申请号：US15532937
申请日：2015-12-04
Applicant: ARRAY BIOPHARMA INC. , CELGENE CORPORATION
Inventor： Shelley Allen , Mark Laurence Boys , Mark J. Chicarelli , Jay Bradford Fell , John P. Fischer , John Gaudino , Erik James Hicken , Ronald Jay Hinklin , Christopher F. Kraser , Ellen Laird , John E. Robinson , Tony P. Tang , Laurence E. Burgess , Robert Andrew Rieger , Jed Pheneger , Yoshitaka Satoh , Katerina Leftheris , Raj K. Raheja , Brydon L. Bennett
IPC: A61K45/06 , C07D487/04 , A61K31/4985 , A61K31/5377
Abstract: Compounds of Formula I: and stereoisomers and pharmaceutically acceptable salts and solvates thereof in which R1, R2, R3 and R4 have the meanings given in the specification, are inhibitors of one or more JAK kinases and are useful in the treatment of JAK kinase-associated diseases and disorders, such as autoimmune diseases, inflammatory diseases, rejection of transplanted organs, tissues and cells, as well as hematologic disorders and malignancies and their co-morbidities.
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公开(公告)号：US20180334441A1
公开(公告)日：2018-11-22
申请号：US16009030
申请日：2018-06-14
Applicant: Array Biopharma Inc.
Inventor： Jeremy Hans , Eli M. Wallace , Qian Zhao , Joseph P. Lyssikatos , Thomas D. Aicher , Ellen Laird , John Robinson , Shelley Allen
IPC: C07D285/12 , C07F9/6539 , C07F9/201 , C07D417/12 , C07D417/06 , C07D271/107 , C07D413/12 , C07D413/06 , C07D413/04 , C07D401/12 , C07D417/04
CPC classification number: C07D285/12 , C07D271/107 , C07D401/12 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/12 , C07F9/201 , C07F9/65392
Abstract: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors.
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Patent Agency Ranking
![PYRAZOLO[3,4-b]PYRIDINE COMPOUNDS AS INHIBITORS OF TAM AND MET KINASES](/abs-image/US/2023/01/12/US20230011441A1/abs.jpg.150x150.jpg)
公开(公告)号：US20230011441A1
公开(公告)日：2023-01-12
申请号：US17376571
申请日：2021-07-15
Applicant: Array BioPharma Inc.
Inventor： Ronald Jay Hinklin , Shelley Allen , Patrick Barbour , Adam Cook , Joshua Dahlke , John Gaudino , Ellen Laird , Oren T. McNulty , Qian Zhao
IPC: C07D471/04
Abstract: Provided herein are compounds of the Formula (I): and stereoisomers, tautomers and pharmaceutically acceptable salts thereof, wherein R1, R2, R9, X1 and G are as defined herein, which are inhibitors of one or more TAM kinases and/or c-Met kinase, and are useful in the treatment and prevention of diseases which can be treated with a TAM kinase inhibitor and/or a c-Met kinase inhibitor.
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公开(公告)号：US20170066733A1
公开(公告)日：2017-03-09
申请号：US15357613
申请日：2016-11-21
Applicant: ARRAY BIOPHARMA INC.
Inventor： Jeremy Hans , Eli M. Wallace , Qian Zhao , Joseph P. Lyssikatos , Thomas D. Aicher , Ellen Laird , John Robinson , Shelley Allen
IPC: C07D285/12 , C07D417/12 , C07F9/6539 , C07D417/06
CPC classification number: C07D285/12 , C07D271/107 , C07D401/12 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/12 , C07F9/201 , C07F9/65392
Abstract: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors.
Abstract translation: 本发明涉及有丝分裂驱动蛋白抑制剂，特别是KSP，以及制备这些抑制剂的方法。 本发明还提供包含本发明抑制剂的药物组合物和利用抑制剂和药物组合物治疗和预防各种疾病的方法。
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公开(公告)号：US09221841B2
公开(公告)日：2015-12-29
申请号：US14663286
申请日：2015-03-19
Applicant: Array BioPharma Inc.
Inventor： Jeremy Hans , Eli M. Wallace , Qian Zhao , Shelley Allen , Ellen Laird , Joseph P. Lyssikatos , John E. Robinson , Christopher P. Corrette , Robert Kirk DeLisle , Walter C. Voegtli
IPC: C07D417/04 , C07D417/14 , C07D285/12 , C07D471/04 , C07D419/04 , C07D487/04 , C07D513/04 , C07D495/04 , C07F9/6539 , C07D497/04
CPC classification number: C07D513/04 , C07D285/12 , C07D417/04 , C07D417/14 , C07D419/04 , C07D471/04 , C07D487/04 , C07D495/04 , C07D497/04 , C07F9/65395
Abstract: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.
Abstract translation: 本发明涉及有丝分裂驱动蛋白抑制剂，特别是KSP，以及制备这些抑制剂的方法。 本发明还提供包含本发明抑制剂的药物组合物和利用抑制剂和药物组合物治疗和预防各种疾病的方法。
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![Pyrazolo[3,4-b]pyridine compounds as inhibitors of TAM and MET kinases](/abs-image/US/2021/08/31/US11104676B2/abs.jpg.150x150.jpg)
公开(公告)号：US11104676B2
公开(公告)日：2021-08-31
申请号：US16555432
申请日：2019-08-29
Applicant: Array BioPharma Inc.
Inventor： Ronald Jay Hinklin , Shelley Allen , Patrick Barbour , Adam Cook , Joshua Dahlke , John Gaudino , Ellen Laird , Oren T. McNulty , Qian Zhao
IPC: C07D471/04
Abstract: Provided herein are compounds of the Formula I: and stereoisomers, tautomers and pharmaceutically acceptable salts thereof, wherein R1, R2, R9, X1 and G are as defined herein, which are inhibitors of one or more TAM kinases and/or c-Met kinase, and are useful in the treatment and prevention of diseases which can be treated with a TAM kinase inhibitor and/or a c-Met kinase inhibitor.
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![4,6-substituted-pyrazolo[1,5-a]pyrazines as janus kinase inhibitors](/abs-image/US/2021/06/08/US11028093B2/abs.jpg.150x150.jpg)
公开(公告)号：US11028093B2
公开(公告)日：2021-06-08
申请号：US16890663
申请日：2020-06-02
Applicant: Array BioPharma Inc. , Celgene Corporation
Inventor： Shelley Allen , Mark Laurence Boys , Mark J. Chicarelli , Jay Bradford Fell , John P. Fischer , John Gaudino , Erik James Hicken , Ronald Jay Hinklin , Christopher F. Kraser , Ellen Laird , John E. Robinson , Tony P. Tang , Laurence E. Burgess , Robert Andrew Rieger , Jed Pheneger , Yoshitaka Satoh , Katerina Leftheris , Raj K. Raheja , Brydon L. Bennett
IPC: A61K45/06 , C07D487/04 , A61K31/4985 , A61K31/5377
Abstract: Compounds of Formula I: and stereoisomers and pharmaceutically acceptable salts and solvates thereof in which R1, R2, R3 and R4 have the meanings given in the specification, are inhibitors of one or more JAK kinases and are useful in the treatment of JAK kinase-associated diseases and disorders, such as autoimmune diseases, inflammatory diseases, rejection of transplanted organs, tissues and cells, as well as hematologic disorders and malignancies and their co-morbidities.
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