公开(公告)号：US09505749B2

公开(公告)日：2016-11-29

申请号：US14423078

申请日：2013-08-27

Applicant: AMGEN INC.

Inventor： Howard Bregman ,  John L. Buchanan ,  Nagasree Chakka ,  Erin F. Dimauro ,  Hakan Gunaydin ,  Angel Guzman-Perez ,  Zihao Hua ,  Xin Huang

IPC: C07D471/02 ,  C07D403/12 ,  C07D401/14 ,  C07D413/14 ,  C07D401/12 ,  C07D239/90 ,  C07D239/95 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04

CPC classification number: C07D471/02 ,  C07D239/90 ,  C07D239/95 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04

Abstract: Compounds of Formula I are useful inhibitors of tankyrase. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein.

公开(公告)号：US20150225396A1

公开(公告)日：2015-08-13

申请号：US14423078

申请日：2013-08-27

Applicant: AMGEN INC.

Inventor： Howard Bregman ,  John L. Buchanan ,  Nagasree Chakka ,  Erin F. Dimauro ,  Hakan Gunaydin ,  Angel Guzman-Perez ,  Zihao Hua ,  Xin Huang

IPC: C07D471/02 ,  C07D413/14 ,  C07D401/14 ,  C07D239/95 ,  C07D401/12 ,  C07D239/90 ,  C07D417/12 ,  C07D413/12 ,  C07D417/14

CPC classification number: C07D471/02 ,  C07D239/90 ,  C07D239/95 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04

Abstract: Compounds of Formula I are useful inhibitors of tankyrase. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein.

Abstract translation: 式I化合物是阻聚酶的有用抑制剂。 式I的化合物具有以下结构：其中本文提供变量的定义。

公开(公告)号：US20150045368A1

公开(公告)日：2015-02-12

申请号：US14383432

申请日：2013-03-01

Applicant: AMGEN INC.

Inventor： Howard Bregman ,  John L. Buchanan ,  Nagasree Chakka ,  Erin F. Dimauro ,  Hakan Gunaydin ,  Angel Guzman-Perez ,  Zihao Hua ,  Hongbing Huang ,  Xin Huang ,  Matthew W. Martin ,  Vinod F. Patel

IPC: C07D487/04 ,  C07D519/00 ,  C07D413/14 ,  C07D413/10 ,  C07D471/04 ,  C07D413/12

CPC classification number: C07D487/04 ,  C07D263/34 ,  C07D413/08 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D473/00 ,  C07D519/00

Abstract: Compounds of Formula (I) and Formula (II) are useful inhibitors of tankyrase. Compounds of Formula (I) and Formula (II) have the following structure: where the definitions of the variables are provided herein.

Abstract translation: 式（I）和式（II）的化合物是阻聚酶的有用抑制剂。 式（I）和式（II）的化合物具有以下结构：其中在此提供变量的定义。

公开(公告)号：US09663508B2

公开(公告)日：2017-05-30

申请号：US15026740

申请日：2014-10-01

Applicant: AMGEN INC.

Inventor： Howard Bregman ,  Nagasree Chakka ,  Erin F. Dimauro ,  Hua Gao ,  Hakan Gunaydin ,  Hongbing Huang ,  Philip R. Olivieri ,  Laurie Schenkel ,  Matthew Weiss

IPC: C07D417/12 ,  C07D213/64 ,  C07D213/26 ,  C07D213/643 ,  C07D213/70 ,  C07D401/04 ,  C07D405/12

CPC classification number: C07D417/12 ,  C07D213/26 ,  C07D213/64 ,  C07D213/643 ,  C07D213/70 ,  C07D401/04 ,  C07D405/12

Abstract: The present invention provides compounds of Formula (Ia), and pharmaceutically acceptable salts thereof. The compounds are useful as inhibitors of voltage-gated sodium channels, in particular Nav 1.7. as described in the specification. The compounds are useful for the treatment of diseases treatable by inhibition of sodium channels such as pain disorders. Also provided are pharmaceutical compositions containing compounds of the present invention, as well as intermediates and processes useful for making the compounds.

公开(公告)号：US09340549B2

公开(公告)日：2016-05-17

申请号：US14383432

申请日：2013-03-01

Applicant: AMGEN INC.

Inventor： Howard Bregman ,  John L. Buchanan ,  Nagasree Chakka ,  Erin F. Dimauro ,  Hakan Gunaydin ,  Angel Guzman-Perez ,  Zihao Hua ,  Hongbing Huang ,  Xin Huang ,  Matthew W. Martin ,  Vinod F. Patel

IPC: C07D413/14 ,  C07D487/04 ,  C07D413/08 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D473/00 ,  C07D263/34 ,  C07D519/00 ,  C07D413/10

CPC classification number: C07D487/04 ,  C07D263/34 ,  C07D413/08 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D473/00 ,  C07D519/00

Abstract: Compounds of Formula (I) and Formula (II) are useful inhibitors of tankyrase. Compounds of Formula (I) and Formula (II) have the following structure: where the definitions of the variables are provided herein.

Abstract translation: 式（I）和式（II）的化合物是阻聚酶的有用抑制剂。 式（I）和式（II）的化合物具有以下结构：其中在此提供变量的定义。