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公开(公告)号:US20150045368A1
公开(公告)日:2015-02-12
申请号:US14383432
申请日:2013-03-01
Applicant: AMGEN INC.
Inventor: Howard Bregman , John L. Buchanan , Nagasree Chakka , Erin F. Dimauro , Hakan Gunaydin , Angel Guzman-Perez , Zihao Hua , Hongbing Huang , Xin Huang , Matthew W. Martin , Vinod F. Patel
IPC: C07D487/04 , C07D519/00 , C07D413/14 , C07D413/10 , C07D471/04 , C07D413/12
CPC classification number: C07D487/04 , C07D263/34 , C07D413/08 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D473/00 , C07D519/00
Abstract: Compounds of Formula (I) and Formula (II) are useful inhibitors of tankyrase. Compounds of Formula (I) and Formula (II) have the following structure: where the definitions of the variables are provided herein.
Abstract translation: 式(I)和式(II)的化合物是阻聚酶的有用抑制剂。 式(I)和式(II)的化合物具有以下结构:其中在此提供变量的定义。
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公开(公告)号:US09340549B2
公开(公告)日:2016-05-17
申请号:US14383432
申请日:2013-03-01
Applicant: AMGEN INC.
Inventor: Howard Bregman , John L. Buchanan , Nagasree Chakka , Erin F. Dimauro , Hakan Gunaydin , Angel Guzman-Perez , Zihao Hua , Hongbing Huang , Xin Huang , Matthew W. Martin , Vinod F. Patel
IPC: C07D413/14 , C07D487/04 , C07D413/08 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D473/00 , C07D263/34 , C07D519/00 , C07D413/10
CPC classification number: C07D487/04 , C07D263/34 , C07D413/08 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D473/00 , C07D519/00
Abstract: Compounds of Formula (I) and Formula (II) are useful inhibitors of tankyrase. Compounds of Formula (I) and Formula (II) have the following structure: where the definitions of the variables are provided herein.
Abstract translation: 式(I)和式(II)的化合物是阻聚酶的有用抑制剂。 式(I)和式(II)的化合物具有以下结构:其中在此提供变量的定义。
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公开(公告)号:US20140066430A1
公开(公告)日:2014-03-06
申请号:US14045715
申请日:2013-10-03
Applicant: Amgen Inc.
Inventor: Victor J. CEE , Holly L. DEAK , Bingfan DU , Stephanie D. GEUNS-MEYER , Brian L. HODOUS , Hanh Nho NGUYEN , Philip R. Olivieri , Vinod F. Patel , Karina ROMERO , Laurie Schenkel
IPC: C07D401/14 , C07D491/048 , C07D417/14 , C07D409/14 , C07D471/04 , C07D495/04
CPC classification number: C07D401/14 , C07D237/30 , C07D239/42 , C07D401/04 , C07D409/04 , C07D409/14 , C07D417/14 , C07D471/04 , C07D491/048 , C07D495/04 , C07D497/04
Abstract: The present invention relates to chemical compounds having a general formula I wherein A1, A2, C1, C2, D, L1, L2, Z and R3, R4, R6, R7 and R8 are defined herein, which are capable of modulating Aurora kinase protein activity, thereby influencing various disease states and conditions related to the activities of Aurora kinase proteins. For example, the compounds are capable of influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, processes of preparing compounds of the invention, synthetic intermediates and methods of treatment of conditions related to the activity of Aurora kinase.
Abstract translation: 本发明涉及具有通式I的化合物,其中A1,A2,C1,C2,D,L1,L2,Z和R3,R4,R6,R7和R8如本文所定义,其能够调节极光激酶蛋白 活动,从而影响与Aurora激酶蛋白活性相关的各种疾病状态和病症。 例如,化合物能够影响细胞周期和细胞增殖的过程,以治疗癌症和与癌症有关的疾病。 本发明还包括药物组合物,制备本发明化合物的方法,合成中间体和治疗与Aurora激酶活性有关的病症的方法。
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