公开(公告)号：US20220214362A1

公开(公告)日：2022-07-07

申请号：US17609995

申请日：2020-05-08

Applicant: ABBOTT LABORATORIES ,  GENERAL ELECTRIC COMPANY

Inventor： Beth McQuiston ,  Luca Marinelli ,  Saul Datwyler

IPC: G01N33/68

Abstract: Disclosed herein are methods that aid in the determination of whether to perform one or more advanced magnetic resonance imaging (MRI) procedures for a head injury by determining the presence or amount of one or more biomarkers in a sample obtained from the human subject. Also disclosed are methods of aiding in the diagnosis and evaluation of a human subject that has sustained or may have sustained an injury to the head, e.g., by assessing biomarker levels in combination with advanced MRI procedures. Further, also disclosed are methods of predicting or aiding in the prediction of the outcome of human subjects that have suffered a traumatic brain injury (TBI) as well as determining the course of treatment or efficacy of a course of treatment for a human subject who has suffered a TBI, e.g., by assessing biomarker levels in combination with advanced MRI procedures.

公开(公告)号：US20230295684A1

公开(公告)日：2023-09-21

申请号：US18147360

申请日：2022-12-28

Applicant: Abbott Laboratories

Inventor： Beth McQuiston ,  Saul Datwyler ,  Raj Chandran

IPC: C12Q1/44 ,  G01N33/68 ,  A61B5/00

CPC classification number: C12Q1/44 ,  A61B5/4064 ,  G01N33/68 ,  G01N2800/40

Abstract: Disclosed herein are methods and systems of determining whether a subject’s levels of GFAP, UCH-L1, or GFAP and UCH-L1 are elevated in a sample collected from the subject. The methods comprise determining whether the levels of GFAP, UCH-L1, or GFAP and UCH-L1 are elevated in the sample, and communicating the determination on or from an instrument. The methods may be used to aid in the diagnosis and evaluation of a subject (e.g., a human subject) that has sustained or may have sustained an injury to the head, such as to determine whether the subject is suffering from a mild, moderate, severe, or moderate to severe traumatic brain injury (TBI).

公开(公告)号：US20210389334A1

公开(公告)日：2021-12-16

申请号：US17316257

申请日：2021-05-10

Applicant: Abbott Laboratories

Inventor： Beth McQuiston ,  Saul Datwyler ,  Raj Chandran ,  Jaime Marino

IPC: G01N33/68

Abstract: Disclosed herein are methods of aiding in the diagnosis and evaluation of a subject that has sustained or may have sustained an injury to the head. For example, the present disclosure provides methods for aiding in the diagnosis and evaluation of a subject to determine whether the subject has sustained a traumatic brain injury (TBI) by detecting or measuring a combination of the levels of ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) and glial fibrillary acidic protein (GFAP) in samples taken at various time points within 48 hours after the subject has sustained or may have sustained an injury to the head.

公开(公告)号：US20210341481A1

公开(公告)日：2021-11-04

申请号：US17316230

申请日：2021-05-10

Applicant: Abbott Laboratories

Inventor： Beth McQuiston ,  Justin Rogers ,  Saul Datwyler ,  Jaime Marino

IPC: G01N33/573 ,  G01N33/68 ,  A61B6/03 ,  A61B6/00

Abstract: Disclosed herein are methods that aid in the diagnosis and evaluation of a human subject that has sustained or may have sustained an injury to the head, such as mild or moderate to severe traumatic brain injury (TBI), using an early biomarker, ubiquitin carboxy-terminal hydrolase L1 (UCH-L1). Also disclosed here are methods that aid in determining whether a human subject that has sustained an injury or may have sustained to the head would benefit from and thus receive a head computerized tomography (CT) scan based on the levels of UCH-L1. These methods involve detecting levels and changes in levels of UCH-L1 in one or more samples taken from a human subject at time points within 24 hours after the subject has sustained or may have sustained an injury to the head.

公开(公告)号：US20210102960A1

公开(公告)日：2021-04-08

申请号：US17104886

申请日：2020-11-25

Applicant: Abbott Laboratories

Inventor： Beth McQuiston ,  Justin Rogers ,  Saul Datwyler ,  Jaime Marino

IPC: G01N33/68 ,  G01N33/573

Abstract: Disclosed herein are methods that aid in the hyperacute diagnosis and evaluation of a human subject that has sustained or may have sustained an injury to the head, such as mild or moderate, severe, or moderate to severe traumatic brain injury (TBI), using an early biomarker, such as ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) glial fibrillary acidic protein (GFAP), or a combination thereof. Also disclosed here are methods that aid in the hyperacute determination of whether a human subject that has sustained an injury or may have sustained to the head would benefit from and thus receive a head computerized tomography (CT) scan based on the levels of UCH-L1. These methods involve detecting levels of early biomarker, such as ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) glial fibrillary acidic protein (GFAP), or a combination thereof, in samples taken from a human subject at a time point within about 2 hours, such as about 10, 12, or 20 minutes, after the subject has sustained or may have sustained an injury to the head.

公开(公告)号：US10849548B2

公开(公告)日：2020-12-01

申请号：US15993588

申请日：2018-05-30

Applicant: Abbott Laboratories

Inventor： Beth McQuiston ,  Frederick Korley ,  Agim Beshiri ,  Jaime Marino ,  Saul Datwyler

IPC: A61K38/00 ,  C12Q1/68 ,  G01N33/567 ,  A61B5/00 ,  G01N33/68 ,  G01N33/543 ,  G01N33/577 ,  C12Q1/6883 ,  G01N33/533 ,  G01N33/564

Abstract: Disclosed herein are methods that aid in the diagnosis and evaluation of a human subject that has sustained or may have sustained an injury to the head, such as mild or a moderate, severe, or moderate to severe traumatic brain injury (TBI), by detecting levels of cardiac troponin I (cTnI) and one or more early biomarkers which are not cTnI, such as ubiquitin carboxy-terminal hydrolase L1 (UCH-L1), glial fibrillary acidic protein (GFAP), or a combination thereof, in biological samples taken from a human subject at time points within about 24 hours of injury after the subject has sustained or may have sustained the injury to the head.

公开(公告)号：US20250123279A1

公开(公告)日：2025-04-17

申请号：US18937081

申请日：2024-11-05

Applicant: Abbott Laboratories

Inventor： Beth McQuiston ,  Justin Rogers ,  Saul Datwyler ,  Jaime Marino

IPC: G01N33/573 ,  A61B6/03 ,  A61B6/50 ,  G01N33/68

Abstract: Disclosed herein are methods that aid in the diagnosis and evaluation of a human subject that has sustained or may have sustained an injury to the head, such as mild or moderate to severe traumatic brain injury (TBI), using an early biomarker, ubiquitin carboxy-terminal hydrolase L1 (UCH-L1). Also disclosed here are methods that aid in determining whether a human subject that has sustained an injury or may have sustained to the head would benefit from and thus receive a head computerized tomography (CT) scan based on the levels of UCH-L1. These methods involve detecting levels and changes in levels of UCH-L1 in one or more samples taken from a human subject at time points within 24 hours after the subject has sustained or may have sustained an injury to the head.

公开(公告)号：US12092647B2

公开(公告)日：2024-09-17

申请号：US17099668

申请日：2020-11-16

Applicant: Abbott Laboratories

Inventor： Beth McQuiston ,  Justin Rogers ,  Jaime Marino ,  Raj Chandran ,  Tianming Zhang ,  Saul Datwyler

IPC: G01N33/68 ,  A61B5/00 ,  A61B5/055 ,  A61B6/03 ,  A61B6/50

CPC classification number: G01N33/6893 ,  A61B5/0042 ,  A61B5/055 ,  A61B6/03 ,  G01N33/6896 ,  A61B6/032 ,  A61B6/501 ,  G01N2333/914 ,  G01N2333/918 ,  G01N2800/28 ,  G01N2800/40 ,  G01N2800/60

Abstract: Disclosed herein are methods that aid in the determination of whether to perform imaging, such as magnetic resonance imaging (MRI) or computerized tomography (CT) scan, on a human subject that has sustained or may have sustained an injury to the head using an early biomarker, such as ubiquitin carboxy-terminal hydrolase L1 (UCH-L1), glial fibrillary acidic protein (GFAP), or a combination thereof. These methods involve detecting levels and changes in levels of UCH-L1 in samples taken from a human subject at time points within 24 hours after the subject has sustained or may have sustained an injury to the head.

公开(公告)号：US12085567B2

公开(公告)日：2024-09-10

申请号：US17095695

申请日：2020-11-11

Applicant: Abbott Laboratories

Inventor： Beth McQuiston ,  Justin Rogers ,  Saul Datwyler ,  Jaime Marino

IPC: G01N33/573 ,  A61B6/03 ,  A61B6/50 ,  G01N33/68

CPC classification number: G01N33/573 ,  A61B6/032 ,  A61B6/501 ,  G01N33/6896 ,  G01N2333/46 ,  G01N2333/916 ,  G01N2333/948 ,  G01N2800/28

Abstract: Disclosed herein are methods that aid in the hyperacute diagnosis and evaluation of a human subject that has sustained or may have sustained an injury to the head, such as mild, moderate, severe, or moderate to severe traumatic brain injury (TBI), using an early biomarker, such as ubiquitin carboxy-terminal hydrolase L1 (UCH-L1), glial fibrillary acidic protein (GFAP), or a combination thereof. Also disclosed here are methods that aid in the hyperacute determination of whether a human subject that has sustained an injury or may have sustained to the head would benefit from and thus receive a head computerized tomography (CT) scan based on the levels of UCH-L1. These methods involve detecting changes of levels of an early biomarker, such as ubiquitin carboxy-terminal hydrolase L1 (UCH-L1), glial fibrillary acidic protein (GFAP), or a combination thereof, in samples taken from a human subject at a time point within about 2 hours, such as about 10, 12, or 20 minutes, after the subject has sustained or may have sustained an injury to the head and a second time point about 3 hours to about 6 hours after the first sample is taken.

公开(公告)号：US20230258661A1

公开(公告)日：2023-08-17

申请号：US18147420

申请日：2022-12-28

Applicant: Abbott Laboratories

Inventor： Beth McQuiston ,  Saul Datwyler ,  Raj Chandran ,  Hongwei Zhang

IPC: G01N33/68

CPC classification number: G01N33/6896 ,  G01N2800/2871 ,  G01N2800/60 ,  G01N2333/916 ,  G01N2333/47 ,  C12Y301/02015

Abstract: Disclosed herein are methods and systems of determining whether a subject's levels of GFAP, UCH-L1, or GFAP and UCH-L1 are elevated in a sample collected from the subject. The methods comprise determining whether the levels of GFAP, UCH-L1, or GFAP and UCH-L1 are elevated in the sample, and communicating the determination on or from an instrument. The methods may be used to aid in the diagnosis and evaluation of a subject (e.g., a human subject) that has sustained or may have sustained an injury to the head, such as to determine whether the subject is suffering from a mild, moderate, severe, or moderate to severe traumatic brain injury (TBI).