-
公开(公告)号：US20200307863A1
公开(公告)日：2020-10-01
申请号：US16762007
申请日：2018-11-01
摘要： A dispenser (1) for liquids includes a reservoir (100) defining a volume (V100) for housing a liquid (150); a delivery tube (200) with a first end (201) attached to the reservoir, and a second end (202) distal from the reservoir, the delivery tube including a passage (203) in fluid communication with the volume of the reservoir and extending away from the reservoir; an applicator element (300) including an applicator tip (320) and a base (310) attached to the second end of the delivery tube, the applicator tip having a plurality of fingers (322) extending away from the base to a distal end of the applicator element distal from the delivery tube; and a removable seal (340), wherein removal of the removable seal creates an opening in the passage at a location upstream of the applicator tip and a fluid distribution channel between the fingers.
-
公开(公告)号：US12102499B2
公开(公告)日：2024-10-01
申请号：US17247244
申请日：2019-06-04
发明人： Randilynn B. Christensen , Kenton D. Budd , Afshin Falsafi , Mahmut Aksit , Jana Ninkovic , Jie J. Liu , Mark B. Agre , Masayuki Nakamura , Jason W. Bjork , Bradley D. Craig , Richard P. Rusin , Paul J. Homnick , Joel D. Oxman , Yizhong Wang , Paul R. Klaiber , Bill H. Dodge
摘要： A method of applying a two-part dental sealant is described comprising providing a syringe device (1) comprising a cartridge (10) including first and second chamber. The first chamber contains a first part of a dental sealant comprising a (meth)acrylate resin and an oxidizing curing agent. The second chamber contains a second part of a dental sealant comprising a (meth)acrylate resin and a reducing curing agent that reacts with the oxidizing curing agent of the first chamber. The first and/or second part of the dental sealant further comprise a single component or multiple components that neutralize acid and promote remineralization. The syringe device comprises a dispensing nozzle (17) comprising a static mixer and an outlet at one end of the cartridge and a plunger (20) at the opposing end of the cartridge. Also described is a kit for storing and applying the dental sealant is described.
-
公开(公告)号：US20210228315A1
公开(公告)日：2021-07-29
申请号：US15734357
申请日：2019-06-05
发明人： Randilynn B. Christensen , Kenton D. Budd , Afshin Falsafi , Mahmut Aksit , Jana Ninkovic , Jie J. Liu , Mark B. Agre , Masayuki Nakamura , Jason W. Bjork , Bradley D. Craig , Richard P. Rusin , Paul J. Homnick , Joel D. Oxman , Yizhong Wang , Paul R. Klaiber
IPC分类号： A61C5/64 , A61C5/68 , A61K6/818 , A61K6/853 , A61K6/876 , A61K6/851 , A61K6/17 , A61K6/62 , A61K6/61 , A61K6/71 , A61K6/887
摘要： A hardenable (e.g. dental) compositions is described comprising an encapsulated material. The encapsulated material comprises a basic core material and an inorganic shell material having certain viscosity criteria. Also described are dispensing devices and kits are described comprising a hardenable (e.g. dental) composition comprising a liquid material and an encapsulated material wherein the encapsulated material comprises a basic core material and an inorganic shell material comprising a metal oxide surrounding the core. The dispensing devices and kits can facilitate the methods of applying the hardenable composition. The hardenable or hardened (e.g. cured) composition can provide various technical effects such as a delayed release of a basic core material, a delayed increase in basicity, promoting remineralization of a tooth or bone structure, and increasing the average alkaline phosphatase (ALP) activity of pulp cells. In some embodiments, the composition is a dental (e.g. sealant) composition to a tooth structure.
-
公开(公告)号：US20190099338A1
公开(公告)日：2019-04-04
申请号：US16148415
申请日：2018-10-01
发明人： Yizhong Wang , Tiffany T. Ton , Melinda B. Gustafson , Jennifer Post , Paul R. Klaiber , Carola A. Carrera Vidal , Joel D. Oxman
摘要： An aqueous oral care fluoride treatment composition, a method of providing fluoride to a patient's tooth surface, and a method of reducing the incidence of dental caries, wherein the composition includes: 0.1 wt-% to 3.0 wt-% of a crosslinked poly acid having carboxylic acid side groups; a pharmaceutically acceptable buffer; 1.0 wt-% to 2.5 wt-% of sodium fluoride; 0.025 wt-% to 1.75 wt-% of a multivalent cation salt; and at least 60 wt-% water; wherein the weight percentages are based on the total weight of the aqueous composition.
-
公开(公告)号：US20230110368A1
公开(公告)日：2023-04-13
申请号：US17948642
申请日：2022-09-20
摘要： A method of removing calculus from a tooth is described comprising: applying aqueous compositions A and B to the tooth surface, wherein the composition A comprises hydrogen peroxide or a precursor thereto and composition B comprises catalase and a stabilizer comprising hydroxyl groups; and removing at least a part of the calculus from the tooth surface. Preferred stabilizers include dipropylene glycol and 1,3 propane diol. Also described are aqueous compositions and kits.
-
公开(公告)号：US20230000596A1
公开(公告)日：2023-01-05
申请号：US17784752
申请日：2020-12-23
发明人： Bhaskar V. Velamakanni , Paul R. Klaiber , Richard P. Rusin , Yizhong Wang , Kevin T. Reddy , Matthew S. Stay , Matthew R.D. Smith , Jennifer J. Post
IPC分类号： A61C7/08 , B33Y10/00 , B33Y80/00 , B29C64/106 , B41M1/12 , B41M1/04 , B29C59/02 , B33Y40/20 , A61C19/06 , A61C5/00
摘要： A method for making a dental appliance configured to position at least one tooth of a patient includes printing a hardenable liquid resin composition on a major surface of a polymeric material to form a pattern thereon, wherein the hardenable liquid resin composition includes a glass ionomer, a resin modified glass ionomer, and mixtures and combinations thereof. A dental appliance is formed from the polymeric material that includes an arrangement of cavities configured to receive one or more teeth.
-
公开(公告)号：US11337902B2
公开(公告)日：2022-05-24
申请号：US16871422
申请日：2020-05-11
发明人： Yizhong Wang , Tiffany T. Ton , Melinda B. Gustafson , Jennifer Post , Paul R. Klaiber , Carola A. Carrera Vidal , Joel D. Oxman
IPC分类号： A61K8/21 , A61K45/06 , A61K33/16 , A61K8/73 , A61K8/27 , A61C19/06 , A61K8/19 , A61K8/24 , A61K8/26 , A61K8/81 , A61Q11/00
摘要： An aqueous oral care fluoride treatment composition, a method of providing fluoride to a patient's tooth surface, and a method of reducing the incidence of dental caries, wherein the composition includes: 0.1 wt-% to 3.0 wt-% of a crosslinked poly acid having carboxylic acid side groups; a pharmaceutically acceptable buffer; 1.0 wt-% to 2.5 wt-% of sodium fluoride; 0.025 wt-% to 1.75 wt-% of a multivalent cation salt; and at least 60 wt-% water; wherein the weight percentages are based on the total weight of the aqueous composition.
-
公开(公告)号：US20210353387A1
公开(公告)日：2021-11-18
申请号：US17284540
申请日：2019-10-11
发明人： Bhaskar V. Velamakanni , Paul R. Klaiber , Richard P. Rusin , Daniel J. Skamser , Negus B. Adefris
摘要： A dental appliance is described, the dental appliance including a polymeric substrate with a plurality of cavities for receiving one or more teeth, an arrangement of engineered microstructures on the substrate wherein the engineered microstructures include a therapeutic agent. The microstructures may be three-dimensionally engineered on a polymeric film disposed on a major surface of the polymeric substrate, wherein the microstructures extend outwards from the surface. The microstructures also comprise a compound releasable from the three-dimensionally engineered microstructures over a predetermined patient wear time.
-
公开(公告)号：US20230134622A1
公开(公告)日：2023-05-04
申请号：US17247244
申请日：2019-06-04
发明人： Randilynn B. Christensen , Kenton D. Budd , Afshin Falsafi , Mahmut Aksit , Jana Ninkovic , Jie J. Liu , Mark B. Agre , Masayuki Nakamura , Jason W. Bjork , Bradley D. Craig , Richard P. Rusin , Paul J. Homnick , Joel D. Oxman , Yizhong Wang , Paul R. Klaiber , Bill H. Dodge
摘要： A method of applying a two-part dental sealant is described comprising providing a syringe device (1) comprising a cartridge (10) including first and second chamber. The first chamber contains a first part of a dental sealant comprising a (meth)acrylate resin and an oxidizing curing agent. The second chamber contains a second part of a dental sealant comprising a (meth)acrylate resin and a reducing curing agent that reacts with the oxidizing curing agent of the first chamber. The first and/or second part of the dental sealant further comprise a single component or multiple components that neutralize acid and promote remineralization. The syringe device comprises a dispensing nozzle (17) comprising a static mixer and an outlet at one end of the cartridge and a plunger (20) at the opposing end of the cartridge. Also described is a kit for storing and applying the dental sealant is described.
-
公开(公告)号：US11377263B2
公开(公告)日：2022-07-05
申请号：US16762007
申请日：2018-11-01
摘要： A dispenser (1) for liquids includes a reservoir (100) defining a volume (V100) for housing a liquid (150); a delivery tube (200) with a first end (201) attached to the reservoir, and a second end (202) distal from the reservoir, the delivery tube including a passage (203) in fluid communication with the volume of the reservoir and extending away from the reservoir; an applicator element (300) including an applicator tip (320) and a base (310) attached to the second end of the delivery tube, the applicator tip having a plurality of fingers (322) extending away from the base to a distal end of the applicator element distal from the delivery tube; and a removable seal (340), wherein removal of the removable seal creates an opening in the passage at a location upstream of the applicator tip and a fluid distribution channel between the fingers.
-
-
-
-
-
-
-
-
-
搜索结果
18 条记录 (耗时 0.027 秒)
