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公开(公告)号：US20240226491A9
公开(公告)日：2024-07-11
申请号：US18491482
申请日：2023-10-20
Applicant: VERO BIOTECH INC.
Inventor： Jason WHITE , Robyn Michelle MCCLURE , Michael Albert AXELROD , Thorsten SCHMIDT , Jin Eul SONG , Mary Virginia SMITH
CPC classification number: A61M16/022 , A61M16/06 , A61M16/1075 , A61M2202/0275 , A61M2205/3379
Abstract: Disclosed herein is a console comprising: at least one air inlet; a first receptacle configured to host a first source of nitric oxide; a second receptacle configured to host a second source of nitric oxide; a controller configured to selectively couple the at least one air inlet to one of the first receptacle or the second receptacle to deliver the nitric oxide from the first or the second source; and an outlet coupled to the first and/or second receptacle and configured to deliver nitric oxide to a subject.
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2.发明公开公开(公告)号：US20240159722A1
公开(公告)日：2024-05-16
申请号：US18353443
申请日：2023-07-17
Applicant: VERO Biotech Inc.
Inventor： David H. FINE , Edward BROMBERG , Thorsten SCHMIDT , Ryan DENTON
IPC: G01N33/00 , G01N27/416
CPC classification number: G01N33/0006 , G01N27/4163 , G01N33/0037
Abstract: A device and method for calibrating a NO delivery device using NO and NO2 measurements, without using a known standard.
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公开(公告)号：US20240131284A1
公开(公告)日：2024-04-25
申请号：US18491482
申请日：2023-10-19
Applicant: VERO BIOTECH INC.
Inventor： Jason WHITE , Robyn Michelle MCCLURE , Michael Albert AXELROD , Thorsten SCHMIDT , Jin Eul SONG , Mary Virginia SMITH
CPC classification number: A61M16/022 , A61M16/06 , A61M16/1075 , A61M2202/0275 , A61M2205/3379
Abstract: Disclosed herein is a console comprising: at least one air inlet; a first receptacle configured to host a first source of nitric oxide; a second receptacle configured to host a second source of nitric oxide; a controller configured to selectively couple the at least one air inlet to one of the first receptacle or the second receptacle to deliver the nitric oxide from the first or the second source; and an outlet coupled to the first and/or second receptacle and configured to deliver nitric oxide to a subject.
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公开(公告)号：US11744978B2
公开(公告)日：2023-09-05
申请号：US17181798
申请日：2021-02-22
Applicant: VERO Biotech Inc.
Inventor： David H. Fine , Bryan Johnson , Gregory Vasquez
CPC classification number: A61M16/12 , A61M16/10 , A61M16/104 , A61M16/107 , A61M16/109 , A61M16/1075 , A61M16/16 , A62B7/08 , A62B21/00 , A61M2202/0275
Abstract: Various systems and devices for generating nitric oxide are disclosed herein. According to one embodiment, the device includes a body having an inlet, an outlet, and a porous solid matrix positioned with the body. The porous solid matrix is coated with an aqueous solution of an antioxidant, wherein the inlet is configured to receive a gas flow and fluidly communicate the gas flow to the outlet through the solid matrix to convert nitrogen dioxide in the gas flow into nitric oxide. The porous solid matrix allows the device to be used in any orientation. Additionally, the porous solid matrix provides a rigid structure suitable to withstand vibrations and abuse without compromising device functionality.
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公开(公告)号：US11291793B2
公开(公告)日：2022-04-05
申请号：US17459052
申请日：2021-08-27
Applicant: VERO Biotech Inc.
Inventor： David P. Rounbehler , David H. Fine
Abstract: Inhalation of low levels of nitric oxide can rapidly and safely decrease pulmonary hypertension in mammals. A nitric oxide delivery system that converts nitrogen dioxide to nitric oxide employs a surface-active material, such as silica gel, coated with an aqueous solution of antioxidant, such as ascorbic acid.
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Patent Agency Ranking
公开(公告)号：US12172890B1
公开(公告)日：2024-12-24
申请号：US17559745
申请日：2021-12-22
Applicant: VERO Biotech Inc.
Inventor： David H. Fine , Thorsten Schmidt , Bryan Johnson , Alessandra Miranda , Edward Bromberg , Marjorie Nelson
Abstract: Dinitrogen tetroxide (N2O4) is synthesized in an apparatus by the reaction of concentrated nitric acid with copper. Oxygen is applied as a carrier gas to convert NO to NO2, and water vapor is removed with a tube dryer. A molecular sieve is applied to reduce and remove impurities.
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公开(公告)号：US20240367975A1
公开(公告)日：2024-11-07
申请号：US18532511
申请日：2023-12-07
Applicant: VERO BIOTECH INC.
Inventor： David H. FINE , Gregory VASQUEZ , David P. ROUNBEHLER
IPC: C01B21/32 , A61D7/04 , A61K33/00 , A61M16/00 , A61M16/10 , A61M16/12 , A61M16/16 , C01B21/24 , G01N27/416
Abstract: Various systems, devices, NO2 absorbents, NO2 scavengers and NO2 recuperator for generating nitric oxide are disclosed herein. According to one embodiment, an apparatus for converting nitrogen dioxide to nitric oxide can include a receptacle including an inlet, an outlet, a surface-active material coated with an aqueous solution of ascorbic acid and an absorbent wherein the inlet is configured to receive a gas flow and fluidly communicate the gas flow to the outlet through the surface-active material and the absorbent such that nitrogen dioxide in the gas flow is converted to nitric oxide.
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公开(公告)号：US11925764B2
公开(公告)日：2024-03-12
申请号：US17461484
申请日：2021-08-30
Applicant: VERO Biotech Inc.
Inventor： David H. Fine
IPC: A61K33/00 , A61K31/655 , A61K47/02 , A61M5/165 , A61M15/00 , A61M15/08 , A61M16/10 , A61M16/12 , A61M35/00 , A61K9/00 , A61K9/70 , A61M5/00
CPC classification number: A61M16/12 , A61K31/655 , A61K33/00 , A61K47/02 , A61M5/165 , A61M15/00 , A61M15/08 , A61M15/085 , A61M16/105 , A61M35/006 , A61K9/0043 , A61K9/0073 , A61K9/7023 , A61M2005/006 , A61M2202/0275 , A61M2205/75
Abstract: A method for delivering nitric oxide therapy to a subject can include administering a composition including a nitric-oxide releasing agent and silica to the subject and releasing a therapeutic amount of nitric oxide from the composition.
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公开(公告)号：US20240075240A1
公开(公告)日：2024-03-07
申请号：US18455177
申请日：2023-08-24
Applicant: VERO Biotech Inc.
Inventor： Barry N. GELLMAN , Eddie TAJUDEEN , Lucas GAMERO , Joshua HOPKINS , Edward E.A. BROMBERG , Ryan DENTON , Bryan J. JOHNSON , David FINE
CPC classification number: A61M16/12 , C01B21/24 , A61M2016/0027 , A61M2202/0275
Abstract: A nitric oxide delivery system can include a cassette which is a single use disposable component used to store liquid N2O4 activate upon operator demand, convert N2O4 to NO2 via a heating element(s) controlled by a console to deliver NO2 at a controlled flow rate, direct concentrated NO2 to a contained pair of conversion cartridges and exhaust NO gas to the console for delivery to the patient.
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公开(公告)号：US11740213B1
公开(公告)日：2023-08-29
申请号：US17666185
申请日：2022-02-07
Applicant: VERO Biotech Inc.
Inventor： David H. Fine , Edward Bromberg , Thorsten Schmidt , Ryan Denton
IPC: G01N33/00 , G01N27/416
CPC classification number: G01N33/0006 , G01N27/4163 , G01N33/0037
Abstract: A device and method for calibrating a NO delivery device using NO and NO2 measurements, without using a known standard.
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