公开(公告)号：US5047540A

公开(公告)日：1991-09-10

申请号：US284590

申请日：1988-11-29

申请人： Susumu Kamata ,  Tatsuo Tsuri ,  Nobuhiro Haga ,  Takeaki Matsui ,  Morio Kishi ,  Kimio Takahashi ,  Sanji Hagashita ,  Kaoru Seno

发明人： Susumu Kamata ,  Tatsuo Tsuri ,  Nobuhiro Haga ,  Takeaki Matsui ,  Morio Kishi ,  Kimio Takahashi ,  Sanji Hagashita ,  Kaoru Seno

IPC分类号： C07C311/32 ,  C07C311/46 ,  C07C323/49 ,  C07C391/00 ,  C07D213/20 ,  C07D215/10 ,  C07D217/10 ,  C07D241/12 ,  C07D249/14 ,  C07D261/12 ,  C07D277/22 ,  C07D277/62 ,  C07D295/088 ,  C07D413/12 ,  C07D521/00

CPC分类号： C07D213/20 ,  C07C311/32 ,  C07C311/46 ,  C07C323/49 ,  C07C391/00 ,  C07D215/10 ,  C07D217/10 ,  C07D231/12 ,  C07D233/56 ,  C07D241/12 ,  C07D249/08 ,  C07D261/12 ,  C07D277/22 ,  C07D277/62 ,  C07D295/088 ,  C07D413/12

摘要： Lipid derivatives represented by the formula: ##STR1## wherein R.sub.1 is alkyl or alkylcarbamoyl; R.sub.2 is lower alkyloxy, lower alkylcarbamoyloxy, lower alkylcarbonylamino, lower alkyloxycarbonylamino, lower alkylureido, lower alkyloxymethyl, lower alkylcarbonylmethyl, cyanomethyl, heterocyclic group, or he0 terocyclyloxy; R.sub.2 ' is hydrogen or R.sub.2 and R.sub.2 ' taken together form --O(CH.sub.2).sub.m -- wherein m is an integer of 1 to 5; R.sub.3, R.sub.4, and R.sub.5 each is hydrogen or lower alkyl or two or three of R.sub.3, R.sub.4, and R.sub.5 taken together with the adjacent nitrogen atom form cyclic ammonio; R.sub.6 is hydrogen or lower alkylcarbonyl; X.sup.- is a counter anion; Y is oxygen or sulfur; and n is an integer of 1 to 10, being useful as PAF antagonists, e.g., as antithrombotic, antivasoconstricting, antibronchoconstricting agent or antitumor agent.