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公开(公告)号：US20070054882A1
公开(公告)日：2007-03-08
申请号：US11503635
申请日：2006-08-14
IPC分类号： A61K31/695 , A61K31/47 , A61K31/382 , A61K31/353 , A61K31/195
CPC分类号： A61K31/382 , A61K31/00 , A61K31/192 , A61K31/195 , A61K31/196 , A61K31/203 , A61K31/353 , A61K31/47 , A61K31/695 , Y10S514/841
摘要： Methods and compositions for inhibiting or preventing spermatogenesis in a male mammal. Also disclosed are compounds and formulations for use in such methods.
摘要翻译： 用于抑制或预防雄性哺乳动物精子发生的方法和组合物。 还公开了用于这些方法的化合物和制剂。
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公开(公告)号：US20050171151A1
公开(公告)日：2005-08-04
申请号：US11016534
申请日：2004-12-17
IPC分类号： C07D335/06 , A61K31/00 , A61K31/196 , A61K31/202 , A61K31/235 , A61K31/352 , A61K31/382 , A61K45/00 , A61P3/06 , A61P9/10 , C07D311/58 , A61K31/47 , A61K31/353
CPC分类号： A61K31/382 , A61K31/00 , A61K31/196 , A61K31/202 , A61K31/352
摘要： The current invention relates to methods for treating hyperlipidemia in mammals, including humans. More specifically, the current invention relates to the use of retinoid or retinoid derivative that is able to act as an antagonist or inverse agonist of a retinoid receptor to treat hyperlipidemia.
摘要翻译： 本发明涉及用于治疗哺乳动物包括人类的高脂血症的方法。 更具体地，本发明涉及能够作为类视黄醇受体的拮抗剂或反向激动剂作用以治疗高脂血症的类视色素或类视色素衍生物的用途。
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3.发明申请Disubstituted chalcone oximes as selective agonists of RAR retinoid receptors 失效二取代查耳酮肟作为RAR类视黄醇受体的选择性激动剂公开(公告)号：US20050148590A1
公开(公告)日：2005-07-07
申请号：US11015994
申请日：2004-12-17
申请人： Kwok Tsang , Santosh Sinha , Xiaoxia Liu , Smita Bhat , Roshantha Chandraratna
发明人： Kwok Tsang , Santosh Sinha , Xiaoxia Liu , Smita Bhat , Roshantha Chandraratna
IPC分类号： A61K31/15 , A61K31/4706 , A61K31/498 , C07C251/40 , C07D215/227 , C07D241/40 , C07D241/42 , C07D307/81 , C07D307/87 , C07D311/58 , C07D335/06
CPC分类号： C07D307/87 , C07D215/227 , C07D335/06
摘要： Compounds of the formula where the variables are as defined in the specification, are useful for preventing or treating emphysema and related pulmonary conditions of mammals and other diseases and conditions which are responsive to RARγ agonist retinoids, such as skin related diseases, including but not limited to acne and psoriasis.
摘要翻译： 其中变量如说明书中所定义的式的化合物可用于预防或治疗哺乳动物的肺气肿和相关的肺部病症以及其它对RARαγ激动剂类视色素有响应的疾病和病症，例如 皮肤相关疾病，包括但不限于痤疮和牛皮癣。
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![7-[(7-ALKOXY)-CHROM-3-EN-6-YL]-HEPTATRIENOIC ACID AND 7-[(3-ALKOXY)-5,6-DIHYDRONAPHTHALEN-2-YL]-HEPTATRIENOIC ACID DERIVATIVES HAVING SERUM GLUCOSE REDUCING ACTIVITY](/abs-image/US/2005/05/05/US20050096380A1/abs.jpg.150x150.jpg)
4.发明申请7-[(7-ALKOXY)-CHROM-3-EN-6-YL]-HEPTATRIENOIC ACID AND 7-[(3-ALKOXY)-5,6-DIHYDRONAPHTHALEN-2-YL]-HEPTATRIENOIC ACID DERIVATIVES HAVING SERUM GLUCOSE REDUCING ACTIVITY 失效7 - [（7-烷氧基）-CHROM-3-EN-6-YL] - 庚酸和7 - [（3-烷氧基）-5,6-二氢萘-2-基] - 嘌呤酸衍生物具有减少血清葡萄糖 活动公开(公告)号：US20050096380A1
公开(公告)日：2005-05-05
申请号：US10696748
申请日：2003-10-29
申请人： Richard Beard , Tien Duong , Janet Takeuchi , Ling Li , Kwok Tsang , Xiaoxia Liu , Jayasree Vasudevan , Liming Wang , Santosh Sinha , Haiqing Yuan , Roshantha Chandraratna
发明人： Richard Beard , Tien Duong , Janet Takeuchi , Ling Li , Kwok Tsang , Xiaoxia Liu , Jayasree Vasudevan , Liming Wang , Santosh Sinha , Haiqing Yuan , Roshantha Chandraratna
IPC分类号： A61K31/21 , A61K31/335 , C07C59/72 , C07C69/587 , C07C69/734 , C07D311/58 , A61K31/353 , A61K31/192 , C07C65/105
CPC分类号： C07C69/734 , C07C59/72 , C07C2601/02 , C07C2602/28 , C07D311/58
摘要： Compounds of the formula where the variables have the meaning defined in the specification are capable of reducing serum glucose levels in diabetic mammals without the undesirable side effects of transiently increasing triglyceride levels and reducing serum thyroxine levels.
摘要翻译： 其中变量具有本说明书中定义的含义的式的化合物能够降低糖尿病哺乳动物中的血清葡萄糖水平，而没有瞬时增加甘油三酯水平和降低血清甲状腺素水平的不良副作用。
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5.发明申请公开(公告)号：US20070112032A1
公开(公告)日：2007-05-17
申请号：US10580879
申请日：2004-11-30
IPC分类号： A61K31/4436
CPC分类号： A61K9/0048 , A61K31/00 , A61K31/203 , A61K31/4436 , Y02A50/401
摘要： The present invention provides a method for reducing and/or preventing degeneration of photoreceptors in the eye of a human caused by radiation in the visible range which comprises administering to said mammal a retinoid compound having RARβ and/or RARδ-selective agonist activity.
摘要翻译： 本发明提供了一种用于减少和/或预防由可见光范围内的辐射引起的人眼中光感受器变性的方法，该方法包括向所述哺乳动物施用具有RARβ和/或 RAR三角选择性激动剂活性。
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公开(公告)号：US20060116425A1
公开(公告)日：2006-06-01
申请号：US11180169
申请日：2005-07-13
IPC分类号： A61K31/203 , A61K31/07
CPC分类号： A61K31/381 , A61K31/00 , A61K31/07 , A61K31/203
摘要： Methods and compositions for the treatment of lung disease such as emphysema and/or bronchopulmonary dysplasia in a mammal. Also disclosed are methods and compositions promoting the formation of alveolar septa and increasing the gas-exchange surface area of a mammalian lung, and for the prevention and/or treatment of alveolar destruction.
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7.发明申请Compounds having selective cytochrome P450RAI-1 or selective cytochrome P450RAI-2 inhibitory activity and methods of obtaining the same 失效具有选择性细胞色素P450RAI-1或选择性细胞色素P450RAI-2抑制活性的化合物及其获得方法公开(公告)号：US20050176689A1
公开(公告)日：2005-08-11
申请号：US11014460
申请日：2004-12-16
申请人： Jayasree Vasudevan , Liming Wang , Xiaoxia Liu , Kwok Tsang , Ling Li , Janet Takeuchi , Thong Vu , Richard Beard , Smita Bhat , Vidyasagar Vuligonda , Roshantha Chandraratna
发明人： Jayasree Vasudevan , Liming Wang , Xiaoxia Liu , Kwok Tsang , Ling Li , Janet Takeuchi , Thong Vu , Richard Beard , Smita Bhat , Vidyasagar Vuligonda , Roshantha Chandraratna
IPC分类号： C07C57/42 , C07C59/64 , C07C59/86 , C07C69/18 , C07C69/73 , C07C69/753 , C07C69/76 , C07C229/34 , C07C229/38 , C07C229/46 , C07C229/50 , C07C275/42 , C07D311/58 , C07D311/64 , C07D311/96 , A61K31/655 , A61K31/4747 , A61K31/497 , A61K31/502 , A61K31/506
CPC分类号： C07C69/73 , C07C57/42 , C07C59/64 , C07C59/86 , C07C69/753 , C07C69/76 , C07C229/34 , C07C229/38 , C07C229/46 , C07C229/50 , C07C275/42 , C07C2601/02 , C07C2602/10 , C07D311/58 , C07D311/64 , C07D311/96
摘要： Compounds of formulas 1 through 17 provided in the specification specifically or selectively inhibit either the cytochrome P450RAI-1 enzyme or the cytochrome P450RAI-2 enzyme.
摘要翻译： 在说明书中提供的式1至17的化合物具体地或选择性地抑制细胞色素P450RAI-1酶或细胞色素P450RAI-2酶。
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8.发明申请公开(公告)号：US20050130232A1
公开(公告)日：2005-06-16
申请号：US10922339
申请日：2004-08-20
CPC分类号： G01N33/6875 , G01N33/743 , G01N33/78 , G01N2333/70567 , G01N2500/10
摘要： The present invention provides methods for identifying an effective agent that modulates a biological activity of a nuclear hormone receptor. In a method of the invention, an isolated receptor-containing complex is assayed for an altered modification state as compared to a control modification state. The presence of an altered modification state serves to identify an effective agent that modulates a biological activity of the nuclear hormone receptor.
摘要翻译： 本发明提供了鉴定调节核激素受体的生物活性的有效试剂的方法。 在本发明的方法中，与对照修饰状态相比，测定了分离的含受体复合物的改变的修饰状态。 改变的修饰状态的存在用于鉴定调节核激素受体的生物活性的有效试剂。
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9.发明申请Compounds having selective cytochrome P450RAI-1 or selective cytochrome P450RAI-2 inhibitory activity and methods of obtaining the same 失效具有选择性细胞色素P450RAI-1或选择性细胞色素P450RAI-2抑制活性的化合物及其获得方法公开(公告)号：US20080004455A1
公开(公告)日：2008-01-03
申请号：US11728313
申请日：2007-03-23
申请人： Jayasree Vasudevan , Liming Wang , Xiaoxia Liu , Kwok Tsang , Ling Li , Janet Takeuchi , Thong Vu , Richard Beard , Smita Bhat , Vidyasagar Vuligonda , Roshantha Chandraratna
发明人： Jayasree Vasudevan , Liming Wang , Xiaoxia Liu , Kwok Tsang , Ling Li , Janet Takeuchi , Thong Vu , Richard Beard , Smita Bhat , Vidyasagar Vuligonda , Roshantha Chandraratna
IPC分类号： C07D311/96 , C07C229/44 , C07C63/331 , C07D311/04
CPC分类号： C07C69/73 , C07C57/42 , C07C59/64 , C07C59/86 , C07C69/753 , C07C69/76 , C07C229/34 , C07C229/38 , C07C229/46 , C07C229/50 , C07C275/42 , C07C2601/02 , C07C2602/10 , C07D311/58 , C07D311/64 , C07D311/96
摘要： Compounds of formulas 1 through 17 provided in the specification specifically or selectively inhibit either the cytochrome P450RAI-1 enzyme or the cytochrome P450RAI-2 enzyme.
摘要翻译： 在说明书中提供的式1至17的化合物具体地或选择性地抑制细胞色素P450RAI-1酶或细胞色素P450RAI-2酶。
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![5-[phenyl-tetrahydronaphthalene-2-yl dihydronaphthalen-2-yl and heteroaryl-cyclopropyl]-pentadienoic acid derivatives having serum glucose reducing activity](/abs-image/US/2005/01/06/US20050004213A1/abs.jpg.150x150.jpg)
10.发明申请5-[phenyl-tetrahydronaphthalene-2-yl dihydronaphthalen-2-yl and heteroaryl-cyclopropyl]-pentadienoic acid derivatives having serum glucose reducing activity 失效具有血清葡萄糖还原活性的5- [苯基 - 四氢萘-2-基二氢萘-2-基和杂芳基 - 环丙基] - 戊二烯酸衍生物公开(公告)号：US20050004213A1
公开(公告)日：2005-01-06
申请号：US10606603
申请日：2003-06-26
申请人： Santosh Sinha , Kwok Tsang , Smita Bhat , Roshantha Chandraratna
发明人： Santosh Sinha , Kwok Tsang , Smita Bhat , Roshantha Chandraratna
IPC分类号： A61P3/10 , C07C59/72 , C07C69/74 , A61K31/215
CPC分类号： C07C59/72
摘要： Compounds of the formula where the variables have the meaning defined in the specification are capable of reducing serum glucose levels in diabetic mammals without the undesirable side effects of reducing serum thyroxine levels and transiently increasing triglyceride levels.
摘要翻译： 其中变量具有本说明书中定义的含义的式的化合物能够降低糖尿病哺乳动物中的血清葡萄糖水平，而没有降低血清甲状腺素水平和短暂增加甘油三酯水平的不良副作用。
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