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公开(公告)号：US20100160249A1
公开(公告)日：2010-06-24
申请号：US12717639
申请日：2010-03-04
申请人： Patrick Couvreur , Barbara Stella , Luigi Cattel , Flavio Rocco , Jack-Michel Renoir , Véronique Rosilio
发明人： Patrick Couvreur , Barbara Stella , Luigi Cattel , Flavio Rocco , Jack-Michel Renoir , Véronique Rosilio
IPC分类号： A61K47/48
CPC分类号： C07H19/06 , A61K47/542 , B82Y30/00 , C07H19/073 , C07H19/16
摘要： The use of squalenic acid or a derivative thereof in formulating at least one polar active principle with a molecular weight of 100 Da or more, in the form of nanoparticles, and pharmaceutical compositions thereof.
摘要翻译： 角鲨烯酸或其衍生物在纳米颗粒形式中配制至少一种分子量为100Da或更多的极性活性成分及其药物组合物的用途。
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公开(公告)号：US07704972B2
公开(公告)日：2010-04-27
申请号：US11631075
申请日：2005-06-23
申请人： Patrick Couvreur , Barbara Stella , Luigi Cattel , Flavio Rocco , Jack-Michel Renoir , Véronique Rosilio
发明人： Patrick Couvreur , Barbara Stella , Luigi Cattel , Flavio Rocco , Jack-Michel Renoir , Véronique Rosilio
CPC分类号： C07H19/06 , A61K47/542 , B82Y30/00 , C07H19/073 , C07H19/16
摘要： The invention concerns a 2′,2′-difluoro-2′-deoxycytidine derivative of general formula (I), wherein: R1, R2 and R3, identical or different, represent independently of one another, a hydrogen atom or an at least C18 hydrocarbon acyl radical and of such conformation that it is capable of providing the compound of general formula (I), a compacted form in a polar solvent medium, at least one of groups R1, R2 and R3 being other than a hydrogen atom.
摘要翻译： 本发明涉及通式（I）的2'，2'-二氟-2'-脱氧胞苷衍生物，其中：R1，R2和R3相同或不同，彼此独立地表示氢原子或至少C18 烃基酰基，并且具有这样的构象，即能够在极性溶剂介质中提供通式（I）的化合物，压实形式，R 1，R 2和R 3中的至少一个不是氢原子。
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公开(公告)号：US20060002963A1
公开(公告)日：2006-01-05
申请号：US10891452
申请日：2004-07-15
申请人： Laura Rabinovich-Guilatt , Yvonne De Kozak , Catherine Dubernet , Gregory Lambert , Simon Benita , Patrick Couvreur , Francine Behar-Cohen
发明人： Laura Rabinovich-Guilatt , Yvonne De Kozak , Catherine Dubernet , Gregory Lambert , Simon Benita , Patrick Couvreur , Francine Behar-Cohen
CPC分类号： A61K9/1075 , A61K9/0048
摘要： A method for treating eye diseases by injecting intraocularly or periocularly a composition comprising an emulsion and optionally at least a pharmaceutical active ingredient.
摘要翻译： 一种通过眼内或眼周注射用于治疗眼部疾病的方法，所述组合物包含乳液和任选的至少一种药物活性成分。
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公开(公告)号：US20110269731A1
公开(公告)日：2011-11-03
申请号：US13126756
申请日：2009-10-28
申请人： Patrick Couvreur , Didier Demaele , Fatima Zouhiri
发明人： Patrick Couvreur , Didier Demaele , Fatima Zouhiri
CPC分类号： A61K47/54
摘要： The present invention relates to a complex made up of at least one beta-lactam molecule covalently bonded to at least one hydrocarbon radical including at least 18 carbon atoms and containing at least one unit of 2-methyl-buta-2-ene, to nanoparticles of said complexes, and to a method for preparing same, said complex and/or said nanoparticles optionally being in the form of a lyophilisate. The present invention also relates to a pharmaceutical composition including at least said complex and/or said nanoparticles. The invention finally relates to said complex and/or to said nanoparticles for the treatment and/or prevention of bacterial infections, in particular caused by strains that are sensitive to beta-lactams.
摘要翻译： 本发明涉及一种由至少一种共价结合至少一个包含至少18个碳原子并含有至少一个2-甲基丁-2-烯单元的烃基的β-内酰胺分子与纳米颗粒组成的复合物 的所述复合物，以及其制备方法，所述复合物和/或所述纳米颗粒任选地为冻干物形式。 本发明还涉及包含至少所述复合物和/或所述纳米颗粒的药物组合物。 本发明最终涉及用于治疗和/或预防细菌感染的所述复合物和/或所述纳米颗粒，特别是由对β-内酰胺类敏感的菌株引起的。
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5.发明授权公开(公告)号：US07833765B2
公开(公告)日：2010-11-16
申请号：US12345647
申请日：2008-12-29
CPC分类号： A61K9/5036 , A61K9/1652
摘要： The invention concerns multiparticulate galenic formulations for oral administration and designed for colon targeted delivery of active principles selected from the group comprising enzymes capable of inactivating macrolides and the like, enzymes capable of inactivating quinolones and β-lactamases.
摘要翻译： 本发明涉及用于口服给药的多颗粒盖仑制剂，并且设计用于结肠靶向递送活性成分，所述活性成分选自能够灭活大环内酯等的酶，能够灭活喹诺酮和β-内酰胺酶的酶。
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公开(公告)号：US20100226991A1
公开(公告)日：2010-09-09
申请号：US12680330
申请日：2008-10-01
IPC分类号： A61K9/14 , C07K16/00 , C07H1/00 , C08B1/00 , C08B37/02 , A61K31/715 , A61K39/395
CPC分类号： C07F15/025
摘要： The invention relates to solid organometallic hybrids with modified surface. Said solid may be used for example for the encapsulation and vectoring of molecules of interest such as active pharmaceutical agents, compounds of interest in cosmetics and markers, for example, contrast agents. Said solids show good results in terms of loading capacity in medicament agents and in biocompatibility.
摘要翻译： 本发明涉及具有改性表面的固体有机金属杂化物。 所述固体可用于例如目标分子的包封和载体活性，例如活性药剂，化妆品中的目标化合物和标记，例如造影剂。 所述固体在药剂中的负载能力和生物相容性方面表现出良好的结果。
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公开(公告)号：US20060182807A1
公开(公告)日：2006-08-17
申请号：US10533084
申请日：2003-06-10
申请人： Christine Vauthier , Cedric Chauvierre , Patrick Couvreur , Denis Labarre , Liliane Leclerc , Michael Marden
发明人： Christine Vauthier , Cedric Chauvierre , Patrick Couvreur , Denis Labarre , Liliane Leclerc , Michael Marden
CPC分类号： A61K9/0026 , A61K9/5138 , A61K9/5161 , A61K38/42 , A61K47/62 , A61K47/6905 , A61K47/6935 , A61K47/6939
摘要： The invention relates to novel compounds, characterized in that they comprise a hemoprotein which is associated with a sequenced block copolymer, comprising an hydrophilic segment which is an oligo or polysaccharide linked to at least one hydrophobic segment of formula (1) wherein x represents H or an radical which is alkyl, CN or CONHR, Y represents a COOR′, CONHR″ or C6H5 radical, wherein R, R′ and R″ represent, independently from each other, a hydrogen atom, a C1-C20 linear ou branched alkyl group, a C1-C20 linear or branched alcoxy group, an amino acid radical, a mono- or poly-hydroxyl acid radical or an aryl ou heteroaryl C5-C12 radical, and forms associated with a gas. The invention can be used as blood substitutes and depolluting agents.
摘要翻译： 本发明涉及新化合物，其特征在于它们包含与序列嵌段共聚物相关的血蛋白，其包含与至少一个式（1）的疏水链连接的寡糖或多糖的亲水链段，其中x表示H或 作为烷基，CN或CONHR的基团，Y表示COOR'，CONHR“或C 6 H 5基团，其中R，R'和R”表示 独立地为氢原子，C 1 -C 20直链支链烷基，C 1 -C 3亚烷基 > 20个直链或支链烷氧基，氨基酸基团，单羟基或多羟基酸基或芳基杂芳基C 5 -C 12烷基， 激进和与气体相关的形式。 本发明可用作血液代用品和去污剂。
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8.发明申请公开(公告)号：US20050249716A1
公开(公告)日：2005-11-10
申请号：US10524318
申请日：2003-08-06
CPC分类号： A61K9/5036 , A61K9/1652
摘要： Forms of colonic delivery suited to be used orally and designed for colonic delivery of active ingredients selected from the group comprising enzymes capable of inactivating macrolide antibiotics and related compounds, enzymes capable of inactivating quinolones, and β-lactamases.
摘要翻译： 适于口服使用并设计用于结肠递送活性成分的结肠递送形式，所述活性成分选自能够灭活大环内酯类抗生素和相关化合物的酶，能够灭活喹诺酮和β-内酰胺酶的酶。
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9.发明授权Nanoparticles comprising at least one polymer and at least one compound able to complex one or more active ingredients 有权纳米颗粒包含至少一种聚合物和至少一种能够络合一种或多种活性成分的化合物公开(公告)号：US06881421B1
公开(公告)日：2005-04-19
申请号：US09648304
申请日：2000-08-25
申请人： Airton Monza da Silveira , Gilles Ponchel , Dominique Duchene , Patrick Couvreur , Francis Puisieux
发明人： Airton Monza da Silveira , Gilles Ponchel , Dominique Duchene , Patrick Couvreur , Francis Puisieux
CPC分类号： A61K9/5138 , A61K9/5161 , A61K47/6951 , B82Y5/00
摘要： Nanoparticles containing at least one active ingredient including at least one polymer, preferably a poly(alkylcyanoacrylate), in which the alkyl group, linear or branched, contains from 1 to 12 carbon atoms, and of at least one compound able to complex said active ingredient. The invention also concerns the method for preparing these nanoparticles.
摘要翻译： 含有至少一种活性成分的纳米颗粒包括至少一种聚合物，优选聚（烷基氰基丙烯酸酯），其中直链或支链的烷基含有1至12个碳原子，以及至少一种能够使所述活性成分复合的化合物 。 本发明还涉及制备这些纳米颗粒的方法。
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10.发明授权Preparation of submicroscopic particles, particles thus obtained and pharmaceutical compositions containing them 失效制备亚显微粒子，由此获得的颗粒和含有它们的药物组合物
公开(公告)号：US4913908A
公开(公告)日：1990-04-03
申请号：US193139
申请日：1988-05-06
申请人： Patrick Couvreur , Michel Roland , Peter Speiser
发明人： Patrick Couvreur , Michel Roland , Peter Speiser
IPC分类号： C08F20/00 , A61K9/14 , A61K9/50 , A61K9/51 , A61K9/58 , A61K38/00 , A61K38/28 , A61K39/00 , A61K49/00 , B01J13/00 , B01J13/14 , C08F22/32
CPC分类号： A61K9/5138 , A61K9/5161 , A61K9/5192 , B01J13/14 , Y10S514/965 , Y10T428/2987
摘要： Process for the preparation of submicroscopic particles formed of a polymerized alkyl cyanoacrylate and containing a biologically active substance.At least one alkyl cyanoacrylate, in which the term "alkyl" denotes an alkyl radical having 1 to 12 carbon atoms, is added, with stirring, to pure water or to an aqueous solution or aqueous colloidal solution of an acid and/or of another water-soluble substance, and the stirring is continued until substantially all the alkyl cyanoacrylate has been converted to submicroscopic particles formed of polyalkyl cyanoacrylate; a biologically active substance is introduced into the reaction medium before the introduction of the monomer or after formation of the submicroscopic particles.The submicroscopic particles are useful as carriers for substances such as medical substances or products for diagnosis.
摘要翻译： 用于制备由聚合的氰基丙烯酸烷基酯并含有生物活性物质形成的亚显微粒子的方法。 将至少一种氰基丙烯酸烷基酯（其中术语“烷基”表示具有1至12个碳原子的烷基）在搅拌下加入纯水或酸和/或另一种的水溶液或水性胶体溶液 并继续搅拌，直到基本上将所有的氰基丙烯酸烷基酯转化为由氰基丙烯酸聚烷基酯形成的亚显微粒子; 在引入单体之前或在形成亚显微粒子之后，将生物活性物质引入反应介质中。 亚显微粒子可用作医药物质或诊断产品等物质的载体。
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