公开(公告)号：US08741932B2

公开(公告)日：2014-06-03

申请号：US13508135

申请日：2010-11-04

Applicant: Sanjay Kumar ,  Sivaramakrishnan Hariharan ,  Mandar Bhonde ,  Nilesh Dagia ,  Rajiv Sharma ,  Pallavi Hanmantrao Mane ,  Pramod Bhaskar Kumar

Inventor： Sanjay Kumar ,  Sivaramakrishnan Hariharan ,  Mandar Bhonde ,  Nilesh Dagia ,  Rajiv Sharma ,  Pallavi Hanmantrao Mane ,  Pramod Bhaskar Kumar

IPC: A01N43/40 ,  A61K31/44 ,  A01N43/54 ,  A61K31/535 ,  C07D491/02 ,  C07D265/36 ,  C07D498/02 ,  C07D413/00

CPC classification number: C07D471/04

Abstract: The present invention relates to compounds of formula (I), wherein Ra, Rb, Rc, Rd, Re and Rf are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases mediated by phosphatidylinositol-3-kinase (PI3K), mammalian target of rapamycin (mTOR), Signal transducer and activator of transcription 3 (STAT 3), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) or a combination thereof particularly in the treatment of cancer and inflammation.

Abstract translation: 本发明涉及式（I）化合物，其中Ra，Rb，Rc，Rd，Re和Rf如本说明书中所定义，其制备方法，含有它们的药物组合物及其在治疗由 磷脂酰肌醇-3-激酶（PI3K），雷帕霉素的哺乳动物靶（mTOR），信号转导和转录激活因子3（STAT3），肿瘤坏死因子-α（TNF-α），白细胞介素-6（IL-6）或 特别是在治疗癌症和炎症中的组合。

公开(公告)号：US20120232072A1

公开(公告)日：2012-09-13

申请号：US13508135

申请日：2010-11-04

Applicant: Sanjay Kumar ,  Sivaramakrishnan Hariharan ,  Mandar Bhonde ,  Nilesh Dagia ,  Rajiv Sharma ,  Pallavi Hanmantrao Mane ,  Pramod Bhaskar Kumar

Inventor： Sanjay Kumar ,  Sivaramakrishnan Hariharan ,  Mandar Bhonde ,  Nilesh Dagia ,  Rajiv Sharma ,  Pallavi Hanmantrao Mane ,  Pramod Bhaskar Kumar

IPC: A61K31/437 ,  A61K31/444 ,  A61K31/4709 ,  A61K31/5377 ,  C07D498/04 ,  A61K31/5383 ,  A61K31/506 ,  A61P35/00 ,  A61P35/02 ,  A61P17/06 ,  A61P17/00 ,  A61P17/14 ,  A61P19/04 ,  A61P29/00 ,  A61P1/00 ,  A61P19/02 ,  A61P19/08 ,  A61P19/10 ,  A61P9/10 ,  A61P9/00 ,  A61P25/00 ,  A61P27/02 ,  A61P1/04 ,  A61P21/00 ,  A61P15/00 ,  A61P37/06 ,  A61P11/00 ,  A61P7/00 ,  A61P11/06 ,  C07D471/04

CPC classification number: C07D471/04

Abstract: The present invention relates to compounds of formula (I), wherein Ra, Rb, Rc, Rd, Re and Rf are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases mediated by phosphatidylinositol-3-kinase (PI3K), mammalian target of rapamycin (mTOR), Signal transducer and activator of transcription 3 (STAT 3), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) or a combination thereof particularly in the treatment of cancer and inflammation.

Abstract translation: 本发明涉及式（I）化合物，其中Ra，Rb，Rc，Rd，Re和Rf如说明书中所定义，其制备方法，含有它们的药物组合物及其在治疗由 磷脂酰肌醇-3-激酶（PI3K），雷帕霉素哺乳动物靶（mTOR），信号转导和转录激活因子3（STAT3），肿瘤坏死因子-α（TNF-α），白细胞介素-6（IL-6）或 特别是在治疗癌症和炎症中的组合。