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1.发明授权公开(公告)号：US07094406B2
公开(公告)日：2006-08-22
申请号：US09851410
申请日：2001-05-07
申请人： Gregory R. Reyes , Patrice O. Yarbough , Daniel W. Bradley , Krzysztof Z. Krawczynski , Albert W. Tam , Kirk E. Fry
发明人： Gregory R. Reyes , Patrice O. Yarbough , Daniel W. Bradley , Krzysztof Z. Krawczynski , Albert W. Tam , Kirk E. Fry
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C07K16/10 , C07K2319/00 , C07K2319/40 , C07K2319/61 , C12N2760/10122 , C12N2770/00022 , C12N2770/24222 , C12N2770/28122 , C12Q1/707 , G01N33/5767 , Y10T436/143333
摘要： Viral proteins derived from an enterically transmitted non-A/non-B viral hepatitis agent (HEV) are disclosed. In one embodiment, the protein is immunologically reactive with antibodies present in individuals infected with the viral hepatitis agent. This protein is useful in a diagnostic method for detecting infection by the enterically transmitted agent. Specific epitopes have been identified that are reactive with sera of individual infected with different strains of HEV. Also disclosed are DNA probes derived from a cloned sequence of the viral agent. These probes are useful for identifying and sequencing the entire viral agent and for assaying the presence of the viral agent in an infected sample, by using probe-specific amplification of virus-derived DNA fragments.
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公开(公告)号：US6120988A
公开(公告)日：2000-09-19
申请号：US478507
申请日：1995-06-07
申请人： Gregory R. Reyes , Patrice O. Yarbough , Daniel W. Bradley , Krzysztof Z. Krawczynski , Albert Tam , Kirk E. Fry
发明人： Gregory R. Reyes , Patrice O. Yarbough , Daniel W. Bradley , Krzysztof Z. Krawczynski , Albert Tam , Kirk E. Fry
CPC分类号： C07K14/005 , C07K16/10 , C12Q1/707 , G01N33/5767 , A61K38/00 , A61K39/00 , C07K2319/00 , C07K2319/40 , C07K2319/61 , C12N2760/10122 , C12N2770/00022 , C12N2770/24222 , C12N2770/28122 , Y10T436/143333
摘要： Viral proteins derived from an enterically transmitted non-A/non-B viral hepatitis agent (HEV) are disclosed. In one embodiment, the protein is immunologically reactive with antibodies present in individuals infected with the viral hepatitis agent. This protein is useful in a diagnostic method for detecting infection by the enterically transmitted agent. Specific epitopes have been identified that are reactive with sera of individual infected with different strains of HEV. Also disclosed are DNA probes derived from a cloned sequence of the viral agent. These probes are useful for identifying and sequencing the entire viral agent and for assaying the presence of the viral agent in an infected sample, by using probe-specific amplification of virus-derived DNA fragments.
摘要翻译： 公开了从肠道传播的非A /非B病毒性肝炎病毒（HEV）衍生的病毒蛋白。 在一个实施方案中，所述蛋白质与存在于感染病毒性肝炎病毒的个体中的抗体具有免疫反应性。 该蛋白质可用于检测肠道传播物质感染的诊断方法。 已经鉴定出与不同HEV病毒株感染的个体血清反应的特异性表位。 还公开了衍生自病毒剂的克隆序列的DNA探针。 这些探针可用于通过使用病毒衍生的DNA片段的探针特异性扩增来鉴定和测序整个病毒剂并测定感染样品中病毒剂的存在。
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3.发明授权DNA sequences of enterically transmitted non-A/non-B hepatitis viral agent and characteristic epitopes thereof 失效肠道传播的非A /非B型肝炎病毒药物的DNA序列及其特征性表位
公开(公告)号：US5824649A
公开(公告)日：1998-10-20
申请号：US475807
申请日：1995-06-07
申请人： Gregory R. Reyes , Patrice O. Yarbough , Daniel W. Bradley , Krzysztof Z. Krawczynski , Albert Tam , Kirk E. Fry
发明人： Gregory R. Reyes , Patrice O. Yarbough , Daniel W. Bradley , Krzysztof Z. Krawczynski , Albert Tam , Kirk E. Fry
IPC分类号： A61K38/00 , A61K39/00 , C07K14/08 , C07K16/10 , C12Q1/70 , G01N33/576 , C07H21/04 , C07K1/00 , C12P21/06
CPC分类号： C07K14/005 , C07K16/10 , C12Q1/707 , G01N33/5767 , A61K38/00 , A61K39/00 , C07K2319/00 , C07K2319/40 , C07K2319/61 , C12N2770/00022
摘要： Viral proteins derived from an enterically transmitted non-A/non-B viral hepatitis agent (HEV) are disclosed. In one embodiment, the protein is immunologically reactive with antibodies present in individuals infected with the viral hepatitis agent. This protein is useful in a diagnostic method for detecting infection by the enterically transmitted agent. Specific epitopes have been identified that are reactive with sera of individual infected with different strains of HEV. Also disclosed are DNA probes derived from a cloned sequence of the viral agent. These probes are useful for identifying and sequencing the entire viral agent and for assaying the presence of the viral agent in an infected sample, by using probe-specific amplification of virus-derived DNA fragments.
摘要翻译： 公开了从肠道传播的非A /非B病毒性肝炎病毒（HEV）衍生的病毒蛋白。 在一个实施方案中，所述蛋白质与存在于感染病毒性肝炎病毒的个体中的抗体具有免疫反应性。 该蛋白质可用于检测肠道传播物质感染的诊断方法。 已经鉴定出与不同HEV病毒株感染的个体血清反应的特异性表位。 还公开了衍生自病毒剂的克隆序列的DNA探针。 这些探针可用于通过使用病毒衍生的DNA片段的探针特异性扩增来鉴定和测序整个病毒剂并测定感染样品中病毒剂的存在。
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公开(公告)号：US06455492B1
公开(公告)日：2002-09-24
申请号：US07870985
申请日：1992-04-20
申请人： Gregory R. Reyes , Daniel W. Bradley , Jr-Shin Twu , Michael A. Purdy , Albert W. Tam , Krzysztof Z. Krawczynski , Patrice O. Yarbough
发明人： Gregory R. Reyes , Daniel W. Bradley , Jr-Shin Twu , Michael A. Purdy , Albert W. Tam , Krzysztof Z. Krawczynski , Patrice O. Yarbough
IPC分类号： A01N3718
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C07K16/10 , C07K2319/00 , C07K2319/23 , C07K2319/40 , C07K2319/61 , C12N2770/28022 , C12N2770/28122 , G01N33/5767
摘要： Antigen and antibody vaccine composition effective in preventing hepatitis E virus (HEV) infection are disclosed. The antigen composition includes peptides corresponding to carboxyl terminal end regions of the second and third open reasing frames of the HEV genome. The composition is effective in preventing HEV infection after vaccination. The antibody composition contains an antibody effective to block HEV infection of human primary hepatocytes in culture.
摘要翻译： 公开了有效预防戊型肝炎病毒（HEV）感染的抗原和抗体疫苗组合物。 抗原组合物包括对应于HEV基因组的第二和第三开放载体框架的羧基末端区域的肽。 该组合物在接种疫苗后有效预防HEV感染。 抗体组合物含有有效阻断培养物中人原代肝细胞HEV感染的抗体。
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公开(公告)号：US06379891B1
公开(公告)日：2002-04-30
申请号：US09553427
申请日：2000-04-19
申请人： Gregory R. Reyes , Patrice O. Yarbough , Daniel W. Bradley , Krzysztof Z. Krawczynski , Albert Tam , Kirk E. Fry
发明人： Gregory R. Reyes , Patrice O. Yarbough , Daniel W. Bradley , Krzysztof Z. Krawczynski , Albert Tam , Kirk E. Fry
IPC分类号： C12Q168
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C07K16/10 , C07K2319/00 , C07K2319/40 , C07K2319/61 , C12N2760/10122 , C12N2770/00022 , C12N2770/24222 , C12N2770/28122 , C12Q1/707 , G01N33/5767 , Y10T436/143333
摘要： Viral proteins derived from an enterically transmitted non-A/non-B viral hepatitis agent (HEV) are disclosed. In one embodiment, the protein is immunologically reactive with antibodies present in individuals infected with the viral hepatitis agent. This protein is useful in a diagnostic method for detecting infection by the enterically transmitted agent. Specific epitopes have been identified that are reactive with sera of individual infected with different strains of HEV. Also disclosed are DNA probes derived from a cloned sequence of the viral agent. These probes are useful for identifying and sequencing the entire viral agent and for assaying the presence of the viral agent in an infected sample, by using probe-specific amplification of virus-derived DNA fragments.
摘要翻译： 公开了从肠道传播的非A /非B病毒性肝炎病毒（HEV）衍生的病毒蛋白。 在一个实施方案中，所述蛋白质与存在于感染病毒性肝炎病毒的个体中的抗体具有免疫反应性。 该蛋白质可用于检测肠道传播物质感染的诊断方法。 已经鉴定出与不同HEV病毒株感染的个体血清反应的特异性表位。 还公开了衍生自病毒剂的克隆序列的DNA探针。 这些探针可用于通过使用病毒衍生的DNA片段的探针特异性扩增来鉴定和测序整个病毒剂并测定感染样品中病毒剂的存在。
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6.发明授权DNA sequences of enterically transmitted non-A/non-B hepatitis viral agent 失效肠道传播的非A /非B型肝炎病毒试剂的DNA序列公开(公告)号：US06229005B1
公开(公告)日：2001-05-08
申请号：US09128275
申请日：1998-08-03
申请人： Gregory R. Reyes , Patrice O. Yarbough , Daniel W. Bradley , Krzysztof Z. Krawczynski , Albert W. Tam , Kirk E. Fry
发明人： Gregory R. Reyes , Patrice O. Yarbough , Daniel W. Bradley , Krzysztof Z. Krawczynski , Albert W. Tam , Kirk E. Fry
IPC分类号： C07H2104
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C07K16/10 , C07K2319/00 , C07K2319/40 , C07K2319/61 , C12N2760/10122 , C12N2770/00022 , C12N2770/24222 , C12N2770/28122 , C12Q1/707 , G01N33/5767 , Y10T436/143333
摘要： Viral proteins derived from an enterically transmitted non-A/non-B viral hepatitis agent (HEV) are disclosed. In one embodiment, the protein is immunologically reactive with antibodies present in individuals infected with the viral hepatitis agent. This protein is useful in a diagnostic method for detecting infection by the enterically transmitted agent. Specific epitopes have been identified that are reactive with sera of individual infected with different strains of HEV. Also disclosed are DNA probes derived from a cloned sequence of the viral agent. These probes are useful for identifying and sequencing the entire viral agent and for assaying the presence of the viral agent in an infected sample, by using probe-specific amplification of virus-derived DNA fragments.
摘要翻译： 公开了从肠道传播的非A /非B病毒性肝炎病毒（HEV）衍生的病毒蛋白。 在一个实施方案中，所述蛋白质与存在于感染病毒性肝炎病毒的个体中的抗体具有免疫反应性。 该蛋白质可用于检测肠道传播物质感染的诊断方法。 已经鉴定出与不同HEV病毒株感染的个体血清反应的特异性表位。 还公开了衍生自病毒剂的克隆序列的DNA探针。 这些探针可用于通过使用病毒衍生的DNA片段的探针特异性扩增来鉴定和测序整个病毒剂并测定感染样品中病毒剂的存在。
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7.发明授权DNA sequences of enterically transmitted non-A/non-B hepatitis viral agent 失效肠道传播的非A /非B型肝炎病毒试剂的DNA序列
公开(公告)号：US5789559A
公开(公告)日：1998-08-04
申请号：US279823
申请日：1994-07-25
申请人： Gregory R. Reyes , Patrice O. Yarbough , Daniel W. Bradley , Krzysztof Z. Krawczynski , Albert Tam , Kirk E. Fry
发明人： Gregory R. Reyes , Patrice O. Yarbough , Daniel W. Bradley , Krzysztof Z. Krawczynski , Albert Tam , Kirk E. Fry
IPC分类号： A61K38/00 , A61K39/00 , C07K14/08 , C07K16/10 , C12Q1/70 , G01N33/576 , C07H21/04 , C12N15/00 , G01N33/20
CPC分类号： C07K14/005 , C07K16/10 , C12Q1/707 , G01N33/5767 , A61K38/00 , A61K39/00 , C07K2319/00 , C07K2319/40 , C07K2319/61 , C12N2760/10122 , C12N2770/00022 , C12N2770/24222 , C12N2770/28122 , Y10T436/143333
摘要： Nucleic acid sequences derived from enterically transmitted nonA/nonB viral hepatitis agent (HEV) are disclosed. DNA sequences encoding specific epitopes within viral protein sequences that are reactive with sera of individuals infected with different strains of HEV are also disclosed. These DNA sequences and fragments thereof are useful for identifying and sequencing the entire viral agent and for assaying the presence of the viral agent in an infected sample, for example by using specific amplification of virus-derived DNA sequences, as well as for producing viral proteins or polypeptides.
摘要翻译： 公开了衍生自肠道传播的非A /非B型肝炎病毒（HEV）的核酸序列。 还公开了编码病毒蛋白质序列中与HEV感染的个体的血清反应的特异性表位的DNA序列。 这些DNA序列及其片段可用于鉴定和测序整个病毒剂并用于测定感染样品中病毒剂的存在，例如通过使用病毒衍生的DNA序列的特异扩增，以及产生病毒蛋白 或多肽。
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公开(公告)号：US5770689A
公开(公告)日：1998-06-23
申请号：US484054
申请日：1995-06-07
申请人： Gregory R. Reyes , Daniel W. Bradley , Jr-Shin Twu , Michael A. Purdy , Albert W. Tam , Krzysztof Z. Krawczynski , Patrice O. Yarbough
发明人： Gregory R. Reyes , Daniel W. Bradley , Jr-Shin Twu , Michael A. Purdy , Albert W. Tam , Krzysztof Z. Krawczynski , Patrice O. Yarbough
IPC分类号： C12N15/09 , A61K38/00 , A61K39/00 , A61K39/29 , A61K39/395 , A61P31/12 , C07K14/08 , C07K16/10 , C12N15/51 , C12P21/08 , C12Q1/70 , G01N33/576 , C07K5/00
CPC分类号： C07K14/005 , C07K16/10 , G01N33/5767 , A61K38/00 , A61K39/00 , C07K2319/00 , C07K2319/23 , C07K2319/40 , C07K2319/61 , C12N2770/28022 , C12N2770/28122
摘要： An antigen composition hepatitis E virus (HEV) infection are disclosed. The antigen composition includes peptides corresponding to carboxyl terminal end regions of the second and third open reading frames of the HEV genome.
摘要翻译： 公开了一种抗原组合物戊型肝炎病毒（HEV）感染。 抗原组合物包括对应于HEV基因组的第二和第三开放阅读框的羧基末端区的肽。
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公开(公告)号：US5741490A
公开(公告)日：1998-04-21
申请号：US259148
申请日：1994-06-13
申请人： Gregory R. Reyes , Daniel W. Bradley , Jr-Shin Twu , Michael A. Purdy , Albert W. Tam , Krzysztof Z. Krawczynski , Patrice D. Yarbough
发明人： Gregory R. Reyes , Daniel W. Bradley , Jr-Shin Twu , Michael A. Purdy , Albert W. Tam , Krzysztof Z. Krawczynski , Patrice D. Yarbough
CPC分类号： C07K14/005 , C07K16/10 , A61K38/00 , A61K39/00 , C07K2319/00 , C07K2319/40 , C07K2319/61 , C12N2770/28122
摘要： Antigen and antibody vaccine composition effective in preventing hepatitis E virus (HEV) infection are disclosed. The antigen composition includes a peptide corresponding to a carboxyl terminal end region of the capsid protein encoded by the second open reading frame 2 of the HEV genome. The composition is effective in preventing HEV infection after vaccination. The antibody composition contains an antibody effective to block HEV infection of human primary hepatocytes in culture.
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