公开(公告)号：US07199225B2

公开(公告)日：2007-04-03

申请号：US10435392

申请日：2003-05-12

Applicant: Jian Ni ,  Ping Feng ,  Patrick J. Dillon ,  Reiner L. Gentz ,  Joseph Merregaert ,  Patrick Smits

Inventor： Jian Ni ,  Ping Feng ,  Patrick J. Dillon ,  Reiner L. Gentz ,  Joseph Merregaert ,  Patrick Smits

IPC: C07K16/28

CPC classification number: C12Q1/6883 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/51 ,  C07K14/47 ,  C07K14/51 ,  C12N2799/026 ,  C12Q2600/156 ,  Y10T436/143333

Abstract: A human ECM-1 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for stimulating the differentiation in growth of osteoblasts and osteoclasts, which may be used to promote the healing of bone fractures and de novo bone formation, for osteoporosis, for and to promote angiogenesis. Antagonists to the polypeptide of the present invention are also disclosed which may be utilized to treat osteodystrophy, osteohypertrophy, osteoma, osteoblastoma and cancers. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention.

Abstract translation: 公开了编码这种多肽的人ECM-1多肽和DNA（RNA），以及通过重组技术产生此类多肽的方法。 还公开了利用这种多肽刺激成骨细胞和破骨细胞生长分化的方法，其可用于促进骨折愈合和从头骨形成，用于骨质疏松症，促进血管生成。 还公开了本发明多肽的拮抗剂，其可用于治疗骨营养不良，骨质肥大，骨瘤，成骨细胞瘤和癌症。 用于鉴定编码本发明多肽的核酸序列中的突变的诊断测定。

公开(公告)号：US20050009141A1

公开(公告)日：2005-01-13

申请号：US10915596

申请日：2004-08-11

Applicant: Jian Ni ,  Ping Feng ,  Patrick Dillon ,  Reiner Gentz ,  Joseph Merregaert ,  Patrick Smits

Inventor： Jian Ni ,  Ping Feng ,  Patrick Dillon ,  Reiner Gentz ,  Joseph Merregaert ,  Patrick Smits

IPC: G01N33/50 ,  A61K38/00 ,  A61K39/395 ,  A61K45/00 ,  A61K48/00 ,  A61P43/00 ,  C07K14/47 ,  C07K14/485 ,  C07K16/22 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12Q1/02 ,  C12Q1/68 ,  C12R1/91 ,  G01N33/15 ,  G01N33/53 ,  G01N33/566 ,  G01N33/577 ,  C07K14/705 ,  C07H21/04 ,  C07K16/28

CPC classification number: C07K14/47 ,  A61K38/00 ,  A61K48/00 ,  C12N2799/026

Abstract: A human epidermal differentiation factor polypeptide and DNA (RNA) encoding such polypeptide and procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for treating and/or preventing skin diseases. Diagnostic assays for detecting mutations in a nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed.

Abstract translation: 公开了通过重组技术产生这种多肽的人表皮分化因子多肽和编码这种多肽的DNA（RNA）和方法。 还公开了利用这种多肽治疗和/或预防皮肤疾病的方法。 还公开了用于检测编码本发明多肽的核酸序列中的突变并用于检测本发明多肽的改变水平的诊断测定。

公开(公告)号：US06610829B2

公开(公告)日：2003-08-26

申请号：US09854549

申请日：2001-05-15

Applicant: Jian Ni ,  Ping Feng ,  Patrick J. Dillon ,  Reiner L. Gentz ,  Joseph Merregaert ,  Patrick Smits

Inventor： Jian Ni ,  Ping Feng ,  Patrick J. Dillon ,  Reiner L. Gentz ,  Joseph Merregaert ,  Patrick Smits

IPC: C07K100

CPC classification number: C12Q1/6883 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/51 ,  C07K14/47 ,  C07K14/51 ,  C12N2799/026 ,  C12Q2600/156 ,  Y10T436/143333

Abstract: A human ECM-1 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for stimulating the differentiation in growth of osteoblasts and osteoclasts, which may be used to promote the healing of bone fractures and de novo bone formation, for osteoporosis, for and to promote angiogenesis. Antagonists to the polypeptide of the present invention are also disclosed which may be utilized to treat osteodystrophy, osteohypertrophy, osteoma, osteoblastoma and cancers. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention.

Abstract translation: 公开了编码这种多肽的人ECM-1多肽和DNA（RNA），以及通过重组技术产生此类多肽的方法。 还公开了利用这种多肽刺激成骨细胞和破骨细胞生长分化的方法，其可用于促进骨折愈合和从头骨形成，用于骨质疏松症，促进血管生成。 还公开了本发明多肽的拮抗剂，其可用于治疗骨营养不良，骨质肥大，骨瘤，成骨细胞瘤和癌症。 用于鉴定编码本发明多肽的核酸序列中的突变的诊断测定。

公开(公告)号：US20080200391A1

公开(公告)日：2008-08-21

申请号：US12105768

申请日：2008-04-18

Applicant: Jian Ni ,  Ping Feng ,  Patrick J. Dillon ,  Reiner L. Gentz ,  Joseph Merregaert ,  Patrick Smits

Inventor： Jian Ni ,  Ping Feng ,  Patrick J. Dillon ,  Reiner L. Gentz ,  Joseph Merregaert ,  Patrick Smits

IPC: A61K38/16 ,  C07H21/00 ,  C12N15/63 ,  C12N5/00 ,  C12P21/00 ,  A61P19/00 ,  C07K16/00 ,  G01N33/00 ,  C07K14/00

CPC classification number: C12Q1/6883 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/51 ,  C07K14/47 ,  C07K14/51 ,  C12N2799/026 ,  C12Q2600/156 ,  Y10T436/143333

Abstract: A human ECM-1 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for stimulating the differentiation in growth of osteoblasts and osteoclasts, which may be used to promote the healing of bone fractures and de novo bone formation, for osteoporosis, for and to promote angiogenesis. Antagonists to the polypeptide of the present invention are also disclosed which may be utilized to treat osteodystrophy, osteohypertrophy, osteoma, osteoblastoma and cancers. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention.

Abstract translation: 公开了编码这种多肽的人ECM-1多肽和DNA（RNA），以及通过重组技术产生此类多肽的方法。 还公开了利用这种多肽刺激成骨细胞和破骨细胞生长分化的方法，其可用于促进骨折愈合和从头骨形成，用于骨质疏松症，促进血管生成。 还公开了本发明多肽的拮抗剂，其可用于治疗骨营养不良，骨质肥大，骨瘤，成骨细胞瘤和癌症。 用于鉴定编码本发明多肽的核酸序列中的突变的诊断测定。

公开(公告)号：US07071312B2

公开(公告)日：2006-07-04

申请号：US10915596

申请日：2004-08-11

Applicant: Jian Ni ,  Ping Feng ,  Patrick J. Dillon ,  Reiner L. Gentz ,  Joseph Merregaert ,  Patrick Smits

Inventor： Jian Ni ,  Ping Feng ,  Patrick J. Dillon ,  Reiner L. Gentz ,  Joseph Merregaert ,  Patrick Smits

IPC: C07K14/475

CPC classification number: C07K14/47 ,  A61K38/00 ,  A61K48/00 ,  C12N2799/026

Abstract: A human epidermal differentiation factor polypeptide and DNA (RNA) encoding such polypeptide and procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for treating and/or preventing skin diseases. Diagnostic assays for detecting mutations in a nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed.

公开(公告)号：US20060063922A1

公开(公告)日：2006-03-23

申请号：US11268629

申请日：2005-11-08

Applicant: Jian Ni ,  Ping Feng ,  Patrick Dillon ,  Reiner Gentz ,  Joseph Merregaert ,  Patrick Smits

Inventor： Jian Ni ,  Ping Feng ,  Patrick Dillon ,  Reiner Gentz ,  Joseph Merregaert ,  Patrick Smits

IPC: C07H21/04 ,  C07K14/475 ,  A61K38/18 ,  C12P21/06

CPC classification number: C07K14/47 ,  A61K38/00 ,  A61K48/00 ,  C12N2799/026

Abstract: A human epidermal differentiation factor polypeptide and DNA (RNA) encoding such polypeptide and procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for treating and/or preventing skin diseases. Diagnostic assays for detecting mutations in a nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed.

公开(公告)号：US20050227282A1

公开(公告)日：2005-10-13

申请号：US11142735

申请日：2005-06-02

Applicant: Jian Ni ,  Ping Feng ,  Patrick Dillon ,  Reiner Gentz ,  Joseph Merregaert ,  Patrick Smits

Inventor： Jian Ni ,  Ping Feng ,  Patrick Dillon ,  Reiner Gentz ,  Joseph Merregaert ,  Patrick Smits

IPC: G01N33/50 ,  A61K38/00 ,  A61K45/00 ,  A61K48/00 ,  A61P9/00 ,  A61P19/10 ,  A61P35/00 ,  A61P43/00 ,  C07H21/04 ,  C07K14/47 ,  C07K14/51 ,  C07K14/785 ,  C07K16/18 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12Q1/68 ,  G01N33/15

CPC classification number: C12Q1/6883 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/51 ,  C07K14/47 ,  C07K14/51 ,  C12N2799/026 ,  C12Q2600/156 ,  Y10T436/143333

Abstract: A human ECM-1 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for stimulating the differentiation in growth of osteoblasts and osteoclasts, which may be used to promote the healing of bone fractures and de novo bone formation, for osteoporosis, for and to promote angiogenesis. Antagonists to the polypeptide of the present invention are also disclosed which may be utilized to treat osteodystrophy, osteohypertrophy, osteoma, osteoblastoma and cancers. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention.

Abstract translation: 公开了编码这种多肽的人ECM-1多肽和DNA（RNA），以及通过重组技术产生此类多肽的方法。 还公开了利用这种多肽刺激成骨细胞和破骨细胞生长分化的方法，其可用于促进骨折愈合和从头骨形成，用于骨质疏松症，促进血管生成。 还公开了本发明多肽的拮抗剂，其可用于治疗骨营养不良，骨质肥大，骨瘤，成骨细胞瘤和癌症。 用于鉴定编码本发明多肽的核酸序列中的突变的诊断测定。