Invention Grant
- Patent Title: Human extracellular matrix-1
- Patent Title (中): 人细胞外基质-1
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Application No.: US10435392Application Date: 2003-05-12
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Publication No.: US07199225B2Publication Date: 2007-04-03
- Inventor: Jian Ni , Ping Feng , Patrick J. Dillon , Reiner L. Gentz , Joseph Merregaert , Patrick Smits
- Applicant: Jian Ni , Ping Feng , Patrick J. Dillon , Reiner L. Gentz , Joseph Merregaert , Patrick Smits
- Applicant Address: US MD Rockville BE Wilrijik
- Assignee: Human Genome Sciences, Inc.,University of Antwerp
- Current Assignee: Human Genome Sciences, Inc.,University of Antwerp
- Current Assignee Address: US MD Rockville BE Wilrijik
- Main IPC: C07K16/28
- IPC: C07K16/28
Abstract:
A human ECM-1 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for stimulating the differentiation in growth of osteoblasts and osteoclasts, which may be used to promote the healing of bone fractures and de novo bone formation, for osteoporosis, for and to promote angiogenesis. Antagonists to the polypeptide of the present invention are also disclosed which may be utilized to treat osteodystrophy, osteohypertrophy, osteoma, osteoblastoma and cancers. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention.
Public/Granted literature
- US20040110677A1 Human extracellular matrix-1 Public/Granted day:2004-06-10
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