公开(公告)号：US20070010540A1

公开(公告)日：2007-01-11

申请号：US11430342

申请日：2006-05-09

Applicant: Lisa Shewchuk ,  Anne Hassell ,  William Holmes ,  James Veal ,  Holly Emerson ,  David Musso ,  Stanley Chamberlain ,  Gregory Peckham

Inventor： Lisa Shewchuk ,  Anne Hassell ,  William Holmes ,  James Veal ,  Holly Emerson ,  David Musso ,  Stanley Chamberlain ,  Gregory Peckham

IPC: A61K31/505 ,  C07D403/02 ,  C07D239/48

CPC classification number: C12N9/12 ,  C07K14/7153 ,  C07K2299/00 ,  G06F19/16

Abstract: A crystal structure of the cfms kinase domain, co-crystal structure with a bound small molecule, as well as methods of using the same in the discovery of cfms inhibitors and in the treatment of diseases mediated by inappropriate cfms activity.

Abstract translation: 具有结合的小分子的cfms激酶结构域，共晶体结构的晶体结构，以及在发现cfms抑制剂以及治疗不适当cfms活性介导的疾病的方法。

公开(公告)号：US20060254525A1

公开(公告)日：2006-11-16

申请号：US11399087

申请日：2006-04-06

Applicant: Lisa Troutman ,  David Musso ,  Melissa Appel ,  Edwin Chan ,  Elijah Dobrusin

Inventor： Lisa Troutman ,  David Musso ,  Melissa Appel ,  Edwin Chan ,  Elijah Dobrusin

IPC: A01K1/035

CPC classification number: A01K1/0272 ,  A01K13/00

Abstract: An integrated pet environment for a mobile vehicle. The integrated pet environment will consist of two pet care units, one located behind the driver's seat and the other located behind the passenger's seat. The driver's seat unit will have storage for pet supplies, and will have a gate which the driver can easily reach with one hand while driving to close off his/her seat, preventing the dog from disturbing him/her while he/she is driving. The passenger's seat unit will have more storage plus a ramp for the dog. The passenger's seat itself will fold all the way down forward and will provide a seat for the dog, accessible from the back of the truck, which will not allow the dog to reach the driver. One of the two storage units will also have food and water dishes.

公开(公告)号：US20060189612A1

公开(公告)日：2006-08-24

申请号：US11407192

申请日：2006-04-20

Applicant: Philip Morgan ,  David Musso ,  John Partridge

Inventor： Philip Morgan ,  David Musso ,  John Partridge

IPC: A61K31/537

CPC classification number: A61K31/5375 ,  A61K31/537

Abstract: Disclosed is the compound (+)-(2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethyl-2-morpholinol and pharmaceutically acceptable salts and solvates thereof, pharmaceutical compositions comprising them, and processes for their preparation and use; also disclosed is a method of treating depression, attention deficit hyperactivity disorder (ADHD), obesity, migraine, pain, sexual dysfunction, Parkinson's disease, Alzheimer's disease, or addiction to cocaine or nicotine-containing (especially tobacco) products using such compound, salts, solvates or compositions.

公开(公告)号：US07503280B2

公开(公告)日：2009-03-17

申请号：US11399087

申请日：2006-04-06

Applicant: Lisa Troutman ,  David Musso ,  Melissa R. Appel ,  Edwin K. Chan ,  Elijah Dobrusin

Inventor： Lisa Troutman ,  David Musso ,  Melissa R. Appel ,  Edwin K. Chan ,  Elijah Dobrusin

IPC: A01K29/00

CPC classification number: A01K1/0272 ,  A01K13/00

Abstract: An integrated pet environment for a mobile vehicle. The integrated pet environment will consist of two pet care units, one located behind the driver's seat and the other located behind the passenger's seat. The driver's seat unit will have storage for pet supplies, and will have a gate which the driver can easily reach with one hand while driving to close off his/her seat, preventing the dog from disturbing him/her while he/she is driving. The passenger's seat unit will have more storage plus a ramp for the dog. The passenger's seat itself will fold all the way down forward and will provide a seat for the dog, accessible from the back of the truck, which will not allow the dog to reach the driver. One of the two storage units will also have food and water dishes.

Abstract translation: 用于移动车辆的集成宠物环境。 整合的宠物环境将包括两个宠物护理单位，一个位于驾驶座后面，另一个位于乘客座位后面。 驾驶座单元将具有宠物用品的存放，并且驾驶员可以在开车关闭他/她的座位时用一只手容易地到达的门，防止狗驾驶时打扰他/她。 乘客座椅单元将有更多的存储加上狗的坡道。 乘客座位本身将一直向下折叠，并为狗提供一个座位，可从卡车后面进入，不允许狗到达司机。 两个储存单位之一也将有食物和水的菜肴。

公开(公告)号：US20050059662A1

公开(公告)日：2005-03-17

申请号：US10850967

申请日：2004-05-21

Applicant: Rustum Boyce ,  Natalia Aurrecoechea ,  Daniel Chu ,  Aaron Smith ,  Christopher Conlee ,  Brian Thompson ,  Judith Kuntz ,  David Musso ,  Kevin Barvian ,  Stephen Thomson ,  William Swain ,  Kien Du ,  Brian Chauder ,  Jason Speake ,  Michael Bishop

Inventor： Rustum Boyce ,  Natalia Aurrecoechea ,  Daniel Chu ,  Aaron Smith ,  Christopher Conlee ,  Brian Thompson ,  Judith Kuntz ,  David Musso ,  Kevin Barvian ,  Stephen Thomson ,  William Swain ,  Kien Du ,  Brian Chauder ,  Jason Speake ,  Michael Bishop

IPC: A61K31/517 ,  A61K31/519 ,  A61K31/525 ,  A61K31/53 ,  A61P3/04 ,  A61P3/10 ,  C07D217/24 ,  C07D239/91 ,  C07D239/95 ,  C07D239/96 ,  C07D253/08 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D475/02 ,  C07D487/02 ,  C07D487/04

CPC classification number: C07D217/24 ,  C07D239/91 ,  C07D239/95 ,  C07D239/96 ,  C07D253/08 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04

Abstract: A variety of small molecule, guanidine-containing molecules capable of acting as MC4-R agonists are provided. The compounds are useful in treating MC4-R mediated diseases when administered to subjects. The compounds have the structure IA, IB, and IC where the values of the variables are defined herein.

Abstract translation: 提供了能够作为MC4-R激动剂的各种小分子，含胍分子。 当给予受试者时，这些化合物可用于治疗MC4-R介导的疾病。 化合物具有结构IA，IB和IC，其中变量的值在本文中定义。

公开(公告)号：US20120208827A1

公开(公告)日：2012-08-16

申请号：US13504547

申请日：2010-10-27

Applicant: Steven Dock ,  Jason Hallman ,  Christopher Laudeman ,  Ronggang Liu ,  Aaron Miller ,  Michael Lee Moore ,  David Musso ,  Cynthia Parrish

Inventor： Steven Dock ,  Jason Hallman ,  Christopher Laudeman ,  Ronggang Liu ,  Aaron Miller ,  Michael Lee Moore ,  David Musso ,  Cynthia Parrish

IPC: A61K31/496 ,  A61K31/437 ,  A61K31/4725 ,  A61K31/428 ,  A61K31/423 ,  A61K31/4184 ,  C07D471/04 ,  C07D401/14 ,  C07D417/14 ,  C07D413/14 ,  C07D403/14 ,  C07D405/14 ,  A61P35/00 ,  C07D403/06 ,  A61K31/517

CPC classification number: C07D403/14 ,  C07D403/06 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04

Abstract: This invention relates to the use of benzimidazole derivatives for the modulation, notably the inhibition of the activity or function of fatty acid synthase (FAS). Suitably, the present invention relates to the use of benzimidazoles in the treatment of cancer.

Abstract translation: 本发明涉及苯并咪唑衍生物用于调节，特别是抑制脂肪酸合成酶（FAS）的活性或功能的用途。 合适地，本发明涉及苯并咪唑在治疗癌症中的用途。

公开(公告)号：US20060181048A1

公开(公告)日：2006-08-17

申请号：US11305078

申请日：2005-12-16

Applicant: Zachary Stowell ,  David Musso ,  Charles Stewart ,  Evan English ,  Christopher D'Eramo ,  Adam Clavelle ,  Shandor Dektor ,  Jayeon Kim ,  Jennifer Perreira ,  Charles Shaw ,  Allan Velzy

Inventor： Zachary Stowell ,  David Musso ,  Charles Stewart ,  Evan English ,  Christopher D'Eramo ,  Adam Clavelle ,  Shandor Dektor ,  Jayeon Kim ,  Jennifer Perreira ,  Charles Shaw ,  Allan Velzy

IPC: B62D53/06 ,  B60K28/00

CPC classification number: B62D53/068 ,  B60K28/16 ,  B60Y2200/14

Abstract: The present invention provides a weight redistribution system including an axle carrier slideably engaged along a length of a trailer frame, wherein the axle carrier including a threaded fixture and the trailer frame includes parallel longitudinal beams having a plurality of equally spaced openings; an axle carrier positioning means including a motor means and a threaded shaft mounted to the trailer frame being in rotational engagement with the threaded fixture of the axle carrier; a weight monitoring system integrated into the axle carrier; an axle carrier locking means including at least one extendable pin mounted on the axle carrier for locking engagement into one of the equally spaced openings in the longitudinal beams; and a control interface for displaying data from the weight monitoring system, actuating the axle carrier positioning means, and actuating the axle carrier locking means.

Abstract translation: 本发明提供了一种重量分配系统，包括沿着拖车架的长度可滑动地接合的轴承架，其中所述轴承架包括螺纹固定装置和所述拖车架包括具有多个等间隔开的开口的平行纵向梁; 轴承定位装置，包括马达装置和安装到拖车架上的螺纹轴，其与轴承架的螺纹固定件旋转接合; 整合在车轴上的重量监控系统; 轴承锁定装置，其包括安装在所述轴承架上的至少一个可延伸销，用于锁定接合到所述纵向梁中的等间隔开的开口之一; 以及控制接口，用于显示来自重量监视系统的数据，致动轴承架定位装置，以及致动轴承架锁定装置。