发明授权
- 专利标题: Method for producing polymer particles, and polymer particles
- 专利标题(中): 生产聚合物颗粒的方法和聚合物颗粒
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申请号: US13994495申请日: 2011-12-14
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公开(公告)号: US09352298B2公开(公告)日: 2016-05-31
- 发明人: Satoshi Nakamura , Tetsuo Fukuta , Kazuhiro Ikkyu , Yu Otani , Hiroshi Kawai
- 申请人: Satoshi Nakamura , Tetsuo Fukuta , Kazuhiro Ikkyu , Yu Otani , Hiroshi Kawai
- 申请人地址: JP Tokyo
- 专利权人: JSR CORPORATION
- 当前专利权人: JSR CORPORATION
- 当前专利权人地址: JP Tokyo
- 代理机构: Oblon, McClelland, Maier & Neustadt, L.L.P.
- 优先权: JP2010-278513 20101214; JP2010-278514 20101214
- 国际申请: PCT/JP2011/078902 WO 20111214
- 国际公布: WO2012/081616 WO 20120621
- 主分类号: B01J20/22
- IPC分类号: B01J20/22 ; B01J20/281 ; B01J20/285 ; C08J3/16 ; C08J3/24 ; C08B1/00 ; C08L1/02 ; C08L1/28 ; C08L5/00 ; C08L5/02 ; C08L5/08 ; C08L5/12 ; C08B15/10 ; C08B37/00 ; C08B37/02 ; C08B37/08 ; B01J20/26
摘要:
Provided are polymer particles which can be used at a high flow rate when used as a filler for chromatography, that is, has excellent resistance flow rate appropriate for processing in large quantities, and also has a high binding capacity for target molecules such as proteins when an appropriate ligand is contained in the particles, and a method for producing the polymer particles; specifically, crosslinked polymer particles and a method for producing the crosslinked polymer particles, polysaccharide composite particles and a method for producing the polysaccharide composite particles, a filler for chromatography using the polymer particles, and an adsorbent for antibody purification. Disclosed are: A. a method for producing polysaccharide composite particles, the method including the following steps (1) to (3): (1) a step of preparing a polysaccharide solution, in which two or more kinds of polysaccharides are dissolved in an ionic liquid; (2) a step of preparing a droplet dispersion liquid of the polysaccharide solution, in which liquid droplets of the polysaccharide solution are dispersed in an organic solvent having low compatibility with the ionic liquid; and (3) a coagulation step in which a composite of the polysaccharides are coagulated to obtain the polysaccharide composite particles; and B. a method for producing a crosslinked polymer particle, the method including a step of allowing a polymer dissolved in an ionic liquid, to react with a crosslinking agent while the polymer is subjected to droplet dispersion in an organic solvent having low compatibility with the ionic liquid.
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