Several methods and circuits configured to mitigate signal interference of at least one aggressor circuit operable on a first clock signal within an interfering frequency range of at least one victim circuit in an IC are disclosed. In an embodiment, a signal interference mitigation circuit is configured to be associated with the aggressor circuit and includes a clock divider circuit and a control circuit. The clock divider circuit is configured to generate the first clock signal based on a second clock signal and a division factor pattern. The control circuit is coupled with the clock divider circuit and configured to determine the division factor pattern and provide the division factor pattern to the clock divider circuit. The division factor pattern comprises a plurality of division factors selected randomly based on a plurality of random numbers, and is configured to control a throughput frequency associated with the signal interference mitigation circuit.