Invention Grant
- Patent Title: Ketoreductase polypeptides for the reduction of acetophenones
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Application No.: US12210195Application Date: 2008-09-13
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Publication No.: US08748143B2Publication Date: 2014-06-10
- Inventor: Jack Liang , Stephane J. Jenne , Emily Mundorff , Charlene Ching , John M. Gruber , Anke Krebber , Gjalt W. Huisman
- Applicant: Jack Liang , Stephane J. Jenne , Emily Mundorff , Charlene Ching , John M. Gruber , Anke Krebber , Gjalt W. Huisman
- Applicant Address: US CA Redwood City US NY New York
- Assignee: Codexis, Inc.,Pfizer, Inc.
- Current Assignee: Codexis, Inc.,Pfizer, Inc.
- Current Assignee Address: US CA Redwood City US NY New York
- Agency: Codexis, Inc.
- Main IPC: C12N9/02
- IPC: C12N9/02 ; C07K14/00 ; C12Q1/26 ; C12P21/00
Abstract:
The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.
Public/Granted literature
- US20090191605A1 Ketoreductase Polypeptides for the Reduction of Acetophenones Public/Granted day:2009-07-30
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