发明授权
US5703188A Process for removing bile salts from a patient and compositions therefor
失效
从患者中除去胆汁盐的方法及其组合物
- 专利标题： Process for removing bile salts from a patient and compositions therefor
- 专利标题（中）： 从患者中除去胆汁盐的方法及其组合物
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申请号： US482969申请日： 1995-06-07
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公开(公告)号： US5703188A公开(公告)日： 1997-12-30
- 发明人: W. Harry Mandeville, III , Stephen Randall Holmes-Farley
- 申请人： W. Harry Mandeville, III , Stephen Randall Holmes-Farley
- 申请人地址： MA Waltham
- 专利权人： GelTex Pharmaceuticals, Inc.
- 当前专利权人： GelTex Pharmaceuticals, Inc.
- 当前专利权人地址： MA Waltham
- 主分类号： A61K31/785
- IPC分类号： A61K31/785 ; A61K31/787 ; A61K31/795 ; C08F8/00 ; C08F8/02 ; C08F8/44 ; C08F220/34 ; C08F220/60 ; C08F10/00 ; C08F12/00 ; C08F30/00 ; C08F110/00
摘要：
A method for removing bile salts from a patient by ion exchange by administering to the patient a therapeutically effective amount of one or more highly crosslinked polymers characterized by a repeat unit having the formula ##STR1## or copolymer thereof, where n is an integer; R.sup.1 is H or a C.sub.1 -C.sub.8 alkyl group: M is ##STR2## Z is O, NR.sup.3, S, or (CH.sub.2).sub.m ; m=0-10; R.sup.3 is H or a C.sub.1 -C.sub.8 alkyl group; and R.sup.2 is ##STR3## where p=0-10, and each R.sup.4, R.sup.5, and R.sup.6, independently is H, a C.sub.1 -C.sub.8 alkyl group, or an aryl group.
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