发明授权
- 专利标题： Peptide compounds, in particular LHRH-antagonists
- 专利标题（中）： 肽化合物，特别是LHRH拮抗剂
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申请号： US142429申请日： 1994-05-04
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公开(公告)号： US5527777A公开(公告)日： 1996-06-18
- 发明人: Paul Thamm , Alessandro Lobbia , Thomas Brumby , Johann Mulzer , Fridtjog Schroder , Ursula Habenicht
- 申请人： Paul Thamm , Alessandro Lobbia , Thomas Brumby , Johann Mulzer , Fridtjog Schroder , Ursula Habenicht
- 申请人地址： DEX Berlin
- 专利权人： Schering Aktiengesellschaft
- 当前专利权人： Schering Aktiengesellschaft
- 当前专利权人地址： DEX Berlin
- 优先权： DEX4117507.7 19910524
- 主分类号： A61K31/415
- IPC分类号： A61K31/415 ; A61K38/00 ; A61K38/04 ; A61K38/24 ; C07C303/36 ; C07C311/19 ; C07D233/61 ; C07D249/08 ; C07D295/14 ; C07D295/15 ; C07D521/00 ; C07K7/00 ; C07K7/23 ; C07K14/575 ; C07K14/59 ; A61K38/02 ; C07K5/00
摘要：
The invention concerns LHRH antagonists of the general formula (I),X-X.sub.1 -X.sub.2 -X.sub.3 -L-Ser-L-Tyr-X.sub.6 -L-Leu-X.sub.8 -L-Pro-X.sub.10 (I)The invention concerns LHRH antagonists of the general formula (I), in which X is an acyl group, X.sub.1 is a D-Nal, X.sub.2 is D-(4-Cl)-Phe, X.sub.3 is D-(3)-Pal, X.sub.6 is D-Cit or D-Neu, X.sub.8 is L-Arg or L-Neu, at least one of the groups X.sub.6 and X.sub.8 being a Neu, and X.sub.10 is D-Ala-NH.sub.2, Neu being a group of formula (II), (IV), (IX) or (X), wherein W is one of the group (a)-(d). The invention includes drugs containing a compound of formula (I), plus the usual auxiliaries and carriers. These drugs are suitable for use in cases of carcinoma of the prostate and in endometriosis, as well as for fertility control.
公开/授权文献
- US4861301A Personal flotation system 公开/授权日：1989-08-29
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