- 专利标题： Farnesyl pyrophosphate analogs
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申请号： US79661申请日： 1993-06-18
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公开(公告)号： US5362906A公开(公告)日： 1994-11-08
- 发明人: Neville J. Anthony , Ta-Jyh Lee , Robert L. Smith , Gerald E. Stokker
- 申请人： Neville J. Anthony , Ta-Jyh Lee , Robert L. Smith , Gerald E. Stokker
- 申请人地址： NJ Rahway
- 专利权人： Merck & Co., Inc.
- 当前专利权人： Merck & Co., Inc.
- 当前专利权人地址： NJ Rahway
- 主分类号： C07F9/24
- IPC分类号： C07F9/24 ; C07C43/30 ; C07C45/29 ; C07C47/21 ; C07C59/42 ; C07C233/04 ; C07C233/05 ; C07F9/38 ; C07F9/40 ; A01N47/10 ; C07C229/00
摘要：
The present invention is directed to farnesyl pyrophosphate analogs which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention, and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
公开/授权文献
- US4863834A Silicon-containing polymers as resists 公开/授权日：1989-09-05
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