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发明授权
US5352708A Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents 失效
非酸性环戊烷庚酸，2-环烷基或芳烷基衍生物作为治疗剂

Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents
摘要：
The present invention provides cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives, substituted in the 1-position with halo, methyl, hydroxyl, nitro, amino, amido, azido, oxime, cyano, thiol, either or thioether groups, e.g., a 1-OH cyclopentane heptanoic acid, 2-(cycloalkyl or arylalkyl) derivatives. The cyclopentane heptanoic acid, 2-(cycloalkyl or arylalkyl) derivatives of the present invention are potent ocular hypotensives, and are particularly suitable for the management of glaucoma. Moreover, the cyclopentane heptanoic, 2-(cycloalkyl or arylalkyl) derivatives of this invention are smooth muscle relaxants with broad application in systemic hypertensive and pulmonary diseases; smooth muscle relaxants with application in gastrointestinal disease, reproduction, fertility, incontinence, shock, etc.
摘要（中）：

本发明提供在1-位被卤素，甲基，羟基，硝基，氨基，酰氨基，叠氮基，肟，氰基，硫醇，或硫醚基取代的环戊烷庚酸，2-环烷基或芳基烷基衍生物，例如 1-OH环戊烷庚酸，2-（环烷基或芳基烷基）衍生物。 本发明的环戊烷庚酸，2-（环烷基或芳基烷基）衍生物是有效的眼睛低血压剂，特别适用于治疗青光眼。 此外，本发明的环戊烷庚酸，2-（环烷基或芳基烷基）衍生物是广泛应用于全身高血压和肺部疾病的平滑肌松弛剂; 平滑肌松弛剂适用于胃肠道疾病，繁殖，生育，失禁，休克等。

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