发明申请
US20170035751A1 AZA Spiro Alkane Derivatives as Inhibitors of Metalloproteases
有权
AZA螺环烷衍生物作为金属蛋白酶抑制剂
- 专利标题： AZA Spiro Alkane Derivatives as Inhibitors of Metalloproteases
- 专利标题（中）： AZA螺环烷衍生物作为金属蛋白酶抑制剂
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申请号： US15204423申请日： 2016-07-07
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公开(公告)号： US20170035751A1公开(公告)日： 2017-02-09
- 发明人: Wenqing Yao , Jincong Zhuo , Meizhong Xu , Fenglei Zhang , Brian W. Metcalf
- 申请人： Incyte Corporation , Incyte Holdings Corporation
- 主分类号： A61K31/496
- IPC分类号： A61K31/496 ; A61K31/495 ; A61K31/4985 ; A61K31/55 ; A61K31/551 ; A61K31/40 ; A61K31/4709 ; A61K31/4725 ; A61K31/4545 ; A61K31/454
摘要：
The present invention provides a compound of Formula I or Formula II: enantiomer, diastereomer, prodrug, solvate, metabolite, or pharmaceutically acceptable salt thereof, wherein constituent variables are provided herein. The compounds of Formula I and II are modulators of metalloproteases and are useful in treating diseases associated with metalloprotease activity such as arthritis, cancer, cardiovascular disorders, skin disorders, inflammation and allergic conditions.
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