Invention Application
US20120231482A1 METHOD, KIT OR DIAGNOSTIC FOR THE DETECTION OF REAGENTS WHICH INDUCE ALTERED CONTRACTILITY
审中-公开
方法，用于检测引起更改合同的试剂的试剂盒或诊断
- Patent Title: METHOD, KIT OR DIAGNOSTIC FOR THE DETECTION OF REAGENTS WHICH INDUCE ALTERED CONTRACTILITY
- Patent Title (中): 方法，用于检测引起更改合同的试剂的试剂盒或诊断
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Application No.: US13509397Application Date: 2010-11-15
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Publication No.: US20120231482A1Publication Date: 2012-09-13
- Inventor: Christopher I. Murray , Jennifer E. Van Eyk , Nazareno Paolocci , Wei Dong Gao , Darren Brian Foster
- Applicant: Christopher I. Murray , Jennifer E. Van Eyk , Nazareno Paolocci , Wei Dong Gao , Darren Brian Foster
- Applicant Address: US MD Baltimore
- Assignee: THE JOHNS HOPKINS UNIVERSITY
- Current Assignee: THE JOHNS HOPKINS UNIVERSITY
- Current Assignee Address: US MD Baltimore
- International Application: PCT/US10/56736 WO 20101115
- Main IPC: C12Q1/02
- IPC: C12Q1/02 ; C07K14/47 ; C12Q1/37 ; G01N33/53 ; G01N27/62
Abstract:
A method of screening for compounds that enhance or depress contractile function, based on measuring the formation of heterodimers of contractile fibers (e.g. Tm and actin, myosin heavy and myosin light chains), for example through disulfide bond formation. Diagnostic and prognostic methods and kits are also provided.
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