发明申请
US20110207726A1 Inhibitors of Human Cathepsin L, Cathepsin B, and Cathepsin S
审中-公开
人组织蛋白酶L,组织蛋白酶B和组织蛋白酶S的抑制剂
- 专利标题: Inhibitors of Human Cathepsin L, Cathepsin B, and Cathepsin S
- 专利标题(中): 人组织蛋白酶L,组织蛋白酶B和组织蛋白酶S的抑制剂
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申请号: US12937495申请日: 2009-04-17
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公开(公告)号: US20110207726A1公开(公告)日: 2011-08-25
- 发明人: Scott L. Diamond , Mary Pat Beavers , Donna Huryn , Michael C. Myers , Amos B. Smith , Parag P. Shah , Zhuqing Liu
- 申请人: Scott L. Diamond , Mary Pat Beavers , Donna Huryn , Michael C. Myers , Amos B. Smith , Parag P. Shah , Zhuqing Liu
- 专利权人: The Trustees of the University of Pennsylvania
- 当前专利权人: The Trustees of the University of Pennsylvania
- 国际申请: PCT/US2009/002412 WO 20090417
- 主分类号: A61K31/538
- IPC分类号: A61K31/538 ; C07D209/20 ; C07D401/12 ; C07D413/12 ; C07D403/12 ; C07D207/09 ; A61K31/4045 ; A61K31/4709 ; A61K31/4725 ; A61K31/40 ; C12N9/99 ; A61P35/00 ; A61P19/10 ; A61P19/02 ; A61P31/12 ; A61P31/14 ; A61P17/14 ; A61P25/00 ; A61P11/06 ; A61P17/06
摘要:
The present invention is directed to novel protease inhibitors that are specific for cathepsin L, cathepsin B, and cathepsin S. Accordingly, the present invention encompasses compositions and methods for treating and preventing diseases and disorders associated with cathepsin L, cathepsin B, or cathepsin S function or activity.
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