Invention Grant
- Patent Title: Multimeric coding nucleic acid and uses thereof
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Application No.: US16280772Application Date: 2019-02-20
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Publication No.: US10428349B2Publication Date: 2019-10-01
- Inventor: Frank DeRosa , Michael Heartlein , Daniel Crawford , Shrirang Karve
- Applicant: Translate Bio, Inc.
- Applicant Address: US MA Lexington
- Assignee: Translate Bio, Inc.
- Current Assignee: Translate Bio, Inc.
- Current Assignee Address: US MA Lexington
- Agency: Proskauer Rose LLP
- Agent Fangli Chen; Julio J. Mendez
- Main IPC: A61K31/70
- IPC: A61K31/70 ; C07H21/04 ; C12N15/63 ; C12N15/85 ; C12N15/67 ; A61K38/18 ; A61K38/45 ; A61K38/44 ; A61K38/17 ; C07K14/705 ; C07K14/505 ; C12N9/10 ; A61K48/00 ; C12P21/00 ; C07H21/02 ; A61K31/7125 ; A61K31/7115 ; C12N9/02 ; A01K67/00
Abstract:
The present invention provides, among other things, multimeric coding nucleic acids that exhibit superior stability for in vivo and in vitro use. In some embodiments, a multimeric coding nucleic acid (MCNA) comprises two or more encoding polynucleotides linked via 3′ ends such that the multimeric coding nucleic acid compound comprises two or more 5′ ends.
Public/Granted literature
- US20190249191A1 MULTIMERIC CODING NUCLEIC ACID AND USES THEREOF Public/Granted day:2019-08-15
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