The utility model provides a novel empty glue mixing pipe of hyposmosis, the rubber tube is outside and glue film of barrier layer, mesoglea, enhancement layer by inlayer to skin in proper order, wherein, the barrier layer is the PPA material layer. The utility model discloses even empty glue mixing pipe still can keep good physical properties under the limit conditions of long -time high temperature, high pressure and high moisture content to satisfy the work demand of R1234yf condensation medium. Thereby overcome prior art cavity glue mixing and managed the technical problem that can't satisfy R1234yf condensation medium work demand.