The invention discloses an anti-seismic energy dissipation stop block of a negative Poisson ratio cell body structure bridge. The stop block is composed of a bottom plate, a back bearing plate, a rearside plate, a middle bearing plate, a middle side plate, a front bearing plate, a front side plate, a wing plate, a counterfort plate, a screw rod and a nut; the bottom plate is connected with the bridge through the screw rod and the nut, and the front bearing plate, the middle bearing plate, the rear bearing plate and the front side plate, the middle plate and the rear side plate and the wing plate are welded into a shoe-shaped cell body structure with a negative Poisson ratio characteristic; the structure is only welded with the bottom plate at the bottom edge of the back bearing plate andis reinforced by the counterfort plate, and the other plates are separated from the bottom plate. The initial lateral rigidity of the stop block is small, the impact force can be effectively reduced,meanwhile, the stop block has a characteristic that the negative Poisson ratio is strengthened by pressure, the lateral rigidity of the stop block can be continuously strengthened along with the seismic load, and good bearing and anti-seismic adaptability are achieved; in addition, the stop block is good in energy dissipation performance, the stop block is provided with a triple energy dissipationsystem comprising elastic deformation of the cell body, plastic deformation of the cell wall and plastic deformation of the back bearing plate, the triple energy dissipation system corresponds to a three-level anti-seismic design goal realizing the effects that no damage is caused at the low-level seismicity, repair is feasible at the moderate-level seismicity, and collapse is prevented at the high-level seismicity respectively.