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发明公开
CN110684082A GIP和GLP-1双激动多肽化合物及药学上可接受的盐与用途 有权 转让

GIP和GLP-1双激动多肽化合物及药学上可接受的盐与用途
摘要：
本发明公开了一类GIP和GLP-1双激动多肽化合物，属于多肽药物化学技术领域。该类GIP和GLP-1双激动多肽化合物的氨基酸序列为：YXaa1EGTFTSDYSIXaa2LDKIAQXaa3AFVQWLIAGGPSSGAPPPS，且该类多肽化合物C末端氨基酸作为C末端伯酰胺被酰胺化。本发明该类多肽化合物的制备方法、药学上可接受的盐、药物组合物和药剂。本发明多肽化合物同时具备降糖及减重效果，可以作为有效原料用于制备治疗或者预防糖尿病的药物或者减肥药物。
摘要（英）：

The invention discloses a GIP and GLP-1 double-agonistic polypeptide compound, and belongs to the technical field of polypeptide medicinal chemistry. The GIP and GLP-1 double-agonistic polypeptide compound has an amino acid sequence as follows: YXaa1EGTFTSDYSIXaa2LDKIAQXaa3AFVQWLIAGGPSSGAPPPS, and C-terminal amino acid of the polypeptide compound is amidated as a C-terminal primary amide. The invention relates to a preparation method, a pharmaceutically acceptable salt, a pharmaceutical composition and a medicament of the polypeptide compound. The polypeptide compound disclosed by the invention has effects of reducing blood glucose and losing weight, and can be used as an effective raw material for preparing a medicament for treating or preventing diabetes or a weight-losing medicament.

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