The invention discloses nutritional meal replacement powder. The nutritional meal replacement powder is prepared from the following components in percentage by mass: 50 to 70 percent of protein powder, 15 to 25 percent of juice powder and 15 to 25 percent of radix puerariae powder. The protein powder is prepared from the following raw materials: walnut kernel, hazelnut kernel, pine nut, sesamum indicum, kernel of cucurbita moschata duch, fructus anacardium occidentalie linn, apricot kernel, kernel of fructus carya illinoensis (Wangh.) Koch and kernel of fructus macadamia ternifolia F.Muell. The juice powder is prepared from the following raw materials: cherry tomato, grape, kiwi fruit pulp, hami melon pulp, banana pulp and passion fruit pulp. The nutritional meal replacement powder disclosed by the invention can be used for simultaneously supplementing various protein, vitamins, minerals, starch and a small amount of grease which are needed by human bodies and is suitable for vegetarianism and weight-losing people thereof.