The invention belongs to the field of medicine synthesis and particularly relates to a preparation process of a regorafenib intermediate. The structure of the regorafenib intermediate is shown in formula (I), 4-methyl-2-pentanone and 4-amino-3-fluorophenol are condensed to obtain a compound in formula (II), N-methyl-4-chloro-2pyridine carboxamide is added to be condensed with the compound in formula (II), and the regorafenib intermediate is obtained. The preparation process of the regorafenib intermediate simple to operate and easy to monitor, has yield up to 90% or above and high efficiency and is applicable to mass industrial production of regorafenib. The prepared regorafenib intermediate has low impurity content, significantly shortens impurity removal purification time and lays a solid foundation for following regorafenib synthesis.