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发明授权
CN108690121B 一种奈米非肽液相制备方法 失效 - 权利终止

一种奈米非肽液相制备方法
摘要：
本发明提供了一种奈米非肽液相制备方法，包括以下步骤：1)以Dpm‑NH2和Fmoc‑Trp(Boc)‑OH制备中间体1H‑Trp(Boc)‑NH‑Dpm；2)制备中间体2H‑Gly‑Trp(Boc)‑NH‑Dpm；3)制备中间体3H‑Arg(Pbf)‑Gly‑Trp(Boc)‑NH‑Dpm；4)制备中间体4H‑4‑hydropro(OtBu)‑Arg(Pbf)‑Gly‑Trp(Boc)‑NH‑Dpm；5)制备中间体5H‑4‑Fphe‑4‑hydropro(OtBu)‑Arg(Pbf)‑Gly‑Trp(Boc)‑NH‑Dpm；6)制备奈米非肽粗品；7)反相色谱制备奈米非肽。本发明的方法纯化收率高，适合规模化生产。
摘要（英）：

Provided is a nano-nemifitide liquid phase preparation method comprising the following steps: 1) preparing intermediate 1H-Trp(Boc)-NH-Dpm with Dpm-NH2 and Fmoc-Trp(Boc)-OH; 2) preparing intermediate 2H-Gly-Trp(Boc)-NH-Dpm; 3) preparing intermediate 3H-Arg(Pbf)-Gly-Trp(Boc)-NH-Dpm; 4) preparing intermediate 4H-4-hydropro(OtBu)-Arg(Pbf)-Gly-Trp(Boc)-NH-Dpm; 5) preparing intermediate 5H-4-Fphe-4-hydropro(OtBu)-Arg(Pbf)-Gly-Trp(Boc)-NH-Dpm; 6) preparing a crude product of nano-nemifitide; and 7) preparing nano-nemifitide by reversed phase chromatography.

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