The invention relates to a vehicle curve safety vehicle speed predication and pre-warning system based on multiple regression analysis. The vehicle curve safety vehicle speed predication and pre-warning system based on the multiple regression analysis comprises a test data collection module, a test data pre-processing module, a test data analysis module, a safety vehicle speed model database, a curve information module, a vehicle type judging module and a curve safety vehicle speed pre-warning module. According to the vehicle curve safety vehicle speed predication and pre-warning system basedon the multiple regression analysis, desired test data are collected, multiple linear regression analysis is carried out on processed test data to obtain a critical transverse adhesion factor model and a transverse load transfer rate model, and the critical transverse adhesion factor model and the transverse load transfer rate model are converted by using a formula to obtain a safety vehicle speedmodel. Collected curve pavement data and vehicle types are input into the safety vehicle speed model database. A curve safety predicated vehicle speed is obtained after calculation and displayed on an LED display screen at the entrance of a curve to warn a driver of a curve safety passing vehicle speed. According to the vehicle curve safety vehicle speed predication and pre-warning system based on the multiple regression analysis, the influences of multiple factors on the curve safety vehicle speed are comprehensively considered, and the curve safety vehicle speed can be accurately predicatedto provide a safety pre-warning vehicle speed for the driver so that the vehicle stably and safely runs through the curve.