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CN108586413B 一种光学纯(S)-6-甲氧基苯并二氢吡喃-3-羧酸的制备方法 失效 - 权利终止

一种光学纯(S)-6-甲氧基苯并二氢吡喃-3-羧酸的制备方法
摘要：
本发明公开了一种光学纯(S)‑6‑甲氧基苯并二氢吡喃‑3‑羧酸的制备方法。其包括以下步骤：往外消旋的6‑甲氧基苯并二氢吡喃‑3‑羧酸中，加入乙腈和解拆剂，加热回流状态下，滴加醇直至溶液澄清，经降温、结晶、分离后，得到铵盐复合物，随后用酸将上述铵盐复合物酸解，游离出光学纯的(S)‑6‑甲氧基苯并二氢吡喃‑3‑羧酸；再对所得(S)‑6‑甲氧基苯并二氢吡喃‑3‑羧酸进行重结晶，得到高光学纯的(S)‑6‑甲氧基苯并二氢吡喃‑3‑羧酸。本发明的制备方法具有原料廉价易得，条件温和，合成工艺简单、解拆剂可循环利用、成本低等优点。
摘要（英）：

The invention discloses a preparation method of optical pure (S)-6-metoxybenzene dihydropyran-3-carboxylic acid. The method includes the following steps of adding acetonitrile and a disassembly agentinto racemic 6-metoxybenzene dihydropyran-3-carboxylic acid, under a heating reflux state, dropwise adding alcohol until the solution is clear, conducting cooling, crystallization and separation, andthen obtaining an ammonium salt compound; using an acid for conducting acidolysis on the ammonium salt compound, and dissociating optical pure (S)-6-metoxybenzene dihydropyran-3-carboxylic acid; conducting recrystallization on obtained (S)-6-metoxybenzene dihydropyran-3-carboxylic acid to obtain highly optical pure (S)-6-metoxybenzene dihydropyran-3-carboxylic acid. The preparation method has theadvantages that the raw materials are low in price and easy to obtain, the conditions are mild, a synthetic process is simple, and the disassembly agent is recyclable and low in cost.

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