The invention relates to the technical field of vehicle pedestrian protection, and discloses a pedestrian protection active pop-up system and a vehicle. The pedestrian protection active pop-up systemcomprises an anti-collision beam, an engine compartment cover and a pop-up device. The pop-up device comprises a pressure sensor, a lifter, a supporter and a controller. The anti-collision beam is arranged on a front bumper of the vehicle, the pressure sensor is arranged in the anti-collision beam, the lifter is disposed below the engine compartment cover and used for lifting the engine compartment cover, the supporter is connected with a vehicle body and used for the supporting and returning of the lifted engine compartment cover, and the controller is used for receiving a pressure signal value of the pressure sensor and controlling the lifting of the lifter according to the pressure signal value. In the pedestrian protection active pop-up system, when a pedestrian collides with the vehicle, the engine compartment cover bounces, which increases a safe energy absorption space above the engine compartment cover, reduces the damage value of the head impacting the compartment cover and reduces the damage caused by the collision between the vehicle and the head of the pedestrian; and at the same time, the jacked engine compartment cover can return quickly, to avoid blocking a driver'sfront line of sight.