Belonging to the field of industrial production technologies of beta-lactam antibiotics, the invention discloses a crystallization method of cephalosporins. The method is carried out in 2-4 crystallization kettles continuously. The method has the advantages of high continuation degree, simple operation and high production efficiency, and is suitable for large-scale industrialized production, improves equipment utilization rate and product yield, and the obtained cephalosporins finished product has an ideal short rod-like crystal form, and the crystals have the characteristics of good integrity, uniform granularity, high purity, good fluidity, and convenient separation, drying and packaging.