The invention relates to the technical field of processing of agriculture products, in particular to a making method of mulberry leaf granules. The mulberry leaf granules are made from the raw materials of mulberry leaves, horseradish tree leaves, beet roots, sweet-scented osmanthus, proteoglycan, honey, hydroxymethyl propyl cellulose, a dispersing agent, a drying assisting agent, a nutrient supplement, a thickening agent and the like, and is made through the steps of treating the raw materials, performing superheated steam drying, performing fermentation, performing filtration, performing clarification, performing mixing and the like. The formula of the mulberry leaf granules is the most scientific and reasonable, the mulberry leaf granules are high in the content of soluble solid substances, rich in nutrition, tiny and uniform in particles, compact and durable, free from agglomeration, fresh in color, easy to melt, fragrant and sweet in smell, pure in mouth feel and low in moisture content, and have natural delicate fragrance of plants, and the quality guarantee period of the mulberry leaf granules is prolonged.