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发明公开
CN107137720A 一种新型包载雷公藤甲素和羟基喜树碱的多臂聚乙二醇纳米药物的制备方法 审中-实审

一种新型包载雷公藤甲素和羟基喜树碱的多臂聚乙二醇纳米药物的制备方法
摘要：
本发明公开了一种新型包载雷公藤甲素和羟基喜树碱的多臂聚乙二醇纳米药物的制备方法。所述的多臂聚乙二醇负载抗癌药物雷公藤甲素过程是由多臂聚乙二醇的多个羧基末端基激活与雷公藤甲素的羟基偶联形成前体药物，并与另一种抗癌药物羟基喜树碱自组装制备多臂聚乙二醇‑雷公藤甲素（羟基喜树碱）纳米药物。通过该方法制备的载双药系统解决雷公藤甲素和羟基喜树碱的水不溶性，具有稳定的载药率，包封率，和稳定适宜的粒径分布，食品级多臂聚乙二醇制备的新药具有高度的生物安全性，且制备工艺简单，成本低，绿色环保适合工业化生产。
摘要（英）：

The invention discloses a preparation method of a multi-armed polyethylene glycol nano drug entrapping triptolide and hydroxycamptothecine. The process of loading an anticancer drug triptolide on multi-armed polyethylene glycol comprises that multiple carboxyl terminals of the multi-armed polyethylene glycol are activated and coupled with hydroxyls of triptolide to form a prodrug, and self assembly is carried out with another anticancer drug hydroxycamptothecine, so that the multi-armed polyethylene glycol-triptolide (hydroxycamptothecine) nano drug is prepared. The prepared system loading double drugs solves the problem of water insolubility of the triptolide and hydroxycamptothecine and has a stable drug loading ratio and entrapment efficiency as well as stable and appropriate particle size distribution, the new drug prepared from food-grade multi-armed polyethylene glycol has highly biological safety, the preparation technology is simple, the cost is low, and the preparation method disclosed by the invention is environment-friendly and applicable to industrial production.

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