The invention discloses a health mangosteen can and a preparation method thereof. The health mangosteen can is prepared from the following raw materials in parts by weight: 16 to 28 parts of mangosteen, 6 to 15 parts of water spinaches, 9 to 17 parts of swiss chards, 12 to 30 parts of oranges, 10 to 22 parts of apples, 8 to 16 parts of pomelos, 6 to 14 parts of pears, 2 to 8 parts of hawthorn tree roots, 2 to 7 parts of pomegranate tree roots, 2 to 4 parts of brown sugar, 2 to 6 parts of gardenia sootepense, 1 to 5 parts of poemlo peel, 0.6 to 1.4 parts of monosidum glutanate, 2 to 5 parts of salt, 2 to 5 parts of vegetable oil and a proper amount of water. The health mangosteen can contains the mangosteen, the water spinaches and the swiss chards, and in addition, multiple types of fleshes and fruit juice and juice obtained by decocting the raw materials such as the hawthorn tree roots and the pomegranate tree roots are added, so that the health mangosteen can has high nutritional value and the effects of moistening the lung, clearing the intestines, replenishing blood, strengthening the spleen and the like, and tastes good.