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发明公开
CN106018595A 毛细管柱法检测3-甲胺基-1,2-丙二醇纯度的方法 失效 - 权利终止

毛细管柱法检测3-甲胺基-1,2-丙二醇纯度的方法
摘要：
本发明提供毛细管柱法检测3‑甲胺基‑1,2‑丙二醇纯度的方法，所述方法，包括试样准备、色谱条件的设定；所述色谱条件的设定，检测器温度为282‑310℃。本发明分析方法，在行业上第一次在检测3‑甲胺基‑1,2‑丙二醇的含量的同时，能够检测3‑甲胺基‑1,2‑丙二醇合成中生成的2‑甲胺基‑1,3‑丙二醇、1，3‑二甲胺基‑丙醇、N,N‑(2，3‑二羟基丙基）甲胺、甘油、聚合甘油（聚合度一般为2）等杂质的含量；本发明分析方法，检测范围广，3‑甲胺基‑1,2‑丙二醇的检测含量在10～50mg范围内线性良好；对本发明检测方法，进行回收率实验，平均回收率为99.5%‑99.6%。
摘要（英）：

The invention provides a method for detecting purity of 3-methylamino-1,2-propylene glycol with a capillary column method. The method comprises steps of sample preparation and chromatographic condition setting, wherein for the chromatographic condition setting, the temperature of a detector is 282-310 DEG C. According to the analysis method, the content of impurities such as 2-methylamino-1,3-propylene glycol, 1,3-dimethylamino-propyl alcohol, N,N-(2,3-dihydroxypropyl) methylamine, glycerol, polyglycerol (with polymerization degree of 2 generally) and the like generated in synthesis of 3-methylamino-1,2-propylene glycol can be detected while the content of 3-methylamino-1,2-propylene glycol is detected in the industry for the first time. The analysis method is wide in detection range, and the linearity is good when the detected content of 3-methylamino-1,2-propylene glycol is in a range of 10-50 mg; a recovery rate experiment is performed on the detection method, and the average recovery rate is 99.5%-99.6%.

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