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发明公开
CN105963286A B环改造脱氢枞酸衍生物的用途 有权

B环改造脱氢枞酸衍生物的用途
摘要：
本发明涉及一类B环改造脱氢枞酸衍生物的新用途。本发明的发现的脱氢枞酸衍生物有较好的抑菌活性，可用作抑菌剂。7‑肟醚酰胺、磺酰胺、脲、硫脲类脱氢枞酸衍生物对金黄色葡萄球菌newman菌株有较好的抑制活性，同时对一些耐药菌株如NRS‑1菌株(耐氨基糖苷类抗生素和四环素的金黄色葡萄球菌)、NRS‑70菌株(耐红霉素和奇放线菌素的金黄色葡萄球菌)、NRS‑100菌株(耐苯唑青霉素和四环素的金黄色葡萄球菌)、NRS‑108菌株(耐庆大霉素的金黄色葡萄球菌)、NRS‑271菌株(耐甲氧西林和利奈唑胺的金黄色葡萄球菌)均有一定程度的抑制活性。
摘要（英）：

The invention relates to novel application of a B-ring modified dehydroabietic acid derivative. The novel application shows that the dehydroabietic acid derivative has relatively good antibacterial activity and can be used as a bacteriostatic agent. 7-oxime ether amide, sulfamide, urea and thiourea dehydroabietic acid derivatives have relatively good inhibition activity on staphylococcus aureus newman strains, and have inhibition activity of certain degrees on drug-resistant strains such as NRS-1 strains (aminoglycoside antibiotics and tetracycline resistant staphylococcus aureus), NRS-70 strains (erythrocin and odd actinomycin resistant staphylococcus aureus), NRS-100 strains (prostaphlin and tetracycline resistant staphylococcus aureus), NRS-108 strains (gentamicin resistant staphylococcus aureus) and NRS-271 strains (methicillin and linezolid resistant staphylococcus aureus).

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